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Systematic Review

Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review

1
Neonatal Department, Medical School, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
2
2nd Department of Pathology, “Attikon” Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
3
Medical School, European University Cyprus, Nicosia 2404, Cyprus
4
Pediatric Surgical Department, “Attikon” Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Dah Ching Ding
Diagnostics 2022, 12(1), 214; https://doi.org/10.3390/diagnostics12010214
Received: 6 December 2021 / Revised: 5 January 2022 / Accepted: 14 January 2022 / Published: 16 January 2022
(This article belongs to the Special Issue Maternal-Fetal Medicine)
The microbiome is vital for the proper function of the gastrointestinal tract (GIT) and the maintenance of overall wellbeing. Gut ischemia may lead to disruption of the intestinal mucosal barrier, resulting in bacterial translocation. In this systematic review, according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, we constructed a search query using the PICOT (Patient, Intervention, Comparison, Outcome, Time) framework. Eligible studies reported in PubMed, up to April 2021 were selected, from which, 57 publications’ data were included. According to these, escape of intraluminal potentially harmful factors into the systemic circulation and their transmission to distant organs and tissues, in utero, at birth, or immediately after, can be caused by reduced blood oxygenation. Various factors are involved in this situation. The GIT is a target organ, with high sensitivity to ischemia–hypoxia, and even short periods of ischemia may cause significant local tissue damage. Fetal hypoxia and perinatal asphyxia reduce bowel motility, especially in preterm neonates. Despite the fact that microbiome arouse the interest of scientists in recent decades, the pathophysiologic patterns which mediate in perinatal hypoxia/asphyxia conditions and gut function have not yet been well understood. View Full-Text
Keywords: microbiome; gut microbiota; microbial translocation; perinatal asphyxia; endotoxin; lipopolysaccharides; animal model microbiome; gut microbiota; microbial translocation; perinatal asphyxia; endotoxin; lipopolysaccharides; animal model
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MDPI and ACS Style

Matara, D.-I.; Pouliakis, A.; Xanthos, T.; Sokou, R.; Kafalidis, G.; Iliodromiti, Z.; Boutsikou, T.; Iacovidou, N.; Salakos, C. Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review. Diagnostics 2022, 12, 214. https://doi.org/10.3390/diagnostics12010214

AMA Style

Matara D-I, Pouliakis A, Xanthos T, Sokou R, Kafalidis G, Iliodromiti Z, Boutsikou T, Iacovidou N, Salakos C. Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review. Diagnostics. 2022; 12(1):214. https://doi.org/10.3390/diagnostics12010214

Chicago/Turabian Style

Matara, Dimitra-Ifigeneia, Abraham Pouliakis, Theodoros Xanthos, Rozeta Sokou, Georgios Kafalidis, Zoi Iliodromiti, Theodora Boutsikou, Nicoletta Iacovidou, and Christos Salakos. 2022. "Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review" Diagnostics 12, no. 1: 214. https://doi.org/10.3390/diagnostics12010214

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