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Diagnostics, Volume 12, Issue 2

2022 February - 331 articles

Cover Story: MALDI-ToF AI is a promising approach to provide more rapid and accurate antibiotic resistance and bring in more precise management of bacterial infections. However, the AI is not perfect yet, and the reason for uncertain or incorrect predictions has not been investigated. In the study, we examined the association between specimen types, MS spectral quality, phenotypic antibiotic susceptibility, bacterial strain composition, and the AI’s predictions. We identified that uncommon bacterial strain or highly complicated bacterial strain composition would be the causes leading to AI uncertainties. Knowing more about MALDI-ToF AI, especially its weakness, can increase our confidence in it and help us to use it better. View this paper.
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Articles (331)

  • Article
  • Open Access
98 Citations
9,803 Views
35 Pages

21 February 2022

Breast cancer has affected many women worldwide. To perform detection and classification of breast cancer many computer-aided diagnosis (CAD) systems have been established because the inspection of the mammogram images by the radiologist is a difficu...

  • Article
  • Open Access
5 Citations
3,387 Views
16 Pages

21 February 2022

Amyloidosis is a heterogeneous group of diseases caused by the extracellular deposition of amyloid insoluble fibrils in multiple organs, resulting in various clinical manifestations. Cardiac amyloidosis (CA) occurs mainly in primary light-chain (AL)...

  • Article
  • Open Access
9 Citations
4,168 Views
13 Pages

Improving Visual-Patient-Avatar Design Prior to Its Clinical Release: A Mixed Qualitative and Quantitative Study

  • Doreen J. Wetli,
  • Lisa Bergauer,
  • Christoph B. Nöthiger,
  • Tadzio R. Roche,
  • Donat R. Spahn,
  • David W. Tscholl and
  • Sadiq Said

21 February 2022

Visual-Patient-avatar, an avatar-based visualisation of patient monitoring, is a newly developed technology aiming to promote situation awareness through user-centred design. Before the technology’s introduction into clinical practice, the init...

  • Article
  • Open Access
2,604 Views
11 Pages

Small Renal Masses without Gross Fat: What Is the Role of Contrast-Enhanced MDCT?

  • Gerta Repeckaite,
  • Kristina Zviniene,
  • Justina Jankauskiene,
  • Algidas Basevicius and
  • Daimantas Milonas

21 February 2022

Increased detection of small renal masses (SRMs) has encouraged research for non-invasive diagnostic tools capable of adequately differentiating malignant vs. benign SRMs and the type of the tumour. Multi-detector computed tomography (MDCT) has been...

  • Article
  • Open Access
3 Citations
2,530 Views
12 Pages

Clinical Implication of Preoperative C-Reactive Protein/Albumin Ratio in Malignant Transformation of Intraductal Papillary Mucinous Neoplasm: A Propensity Score Analysis

  • Hirotsugu Maruyama,
  • Kojiro Tanoue,
  • Yuki Ishikawa-Kakiya,
  • Masafumi Yamamura,
  • Akira Higashimori,
  • Masaki Ominami,
  • Yuji Nadatani,
  • Shusei Fukunaga,
  • Koji Otani and
  • Yasuhiro Fujiwara
  • + 8 authors

21 February 2022

Background: Inflammation-based scoring has been reported to be useful for predicting the recurrence and prognosis of various carcinomas. This study retrospectively investigated the relationship between inflammation-based score and intraductal papilla...

  • Review
  • Open Access
3 Citations
6,094 Views
9 Pages

The Juxtaoral Organ: From Anatomy to Clinical Relevance

  • Gaia Favero,
  • Rita Rezzani and
  • Luigi Fabrizio Rodella

21 February 2022

The juxtaoral organ was first described 1885 as a rudimentary structure that developed and disappeared in the embryonic period. Since then, it has been studied further and is now known to be a permanent anatomical structure of considerable importance...

  • Article
  • Open Access
8 Citations
3,832 Views
11 Pages

Predictive Factors for Successful Treatment of Deep Incisional Surgical Site Infections following Instrumented Spinal Surgeries: Retrospective Review of 1832 Cases

  • Masahiro Kuroiwa,
  • Jordy Schol,
  • Daisuke Sakai,
  • Natsumi Horikita,
  • Akihiko Hiyama,
  • Hiroyuki Katoh,
  • Yukihiro Yamamoto,
  • Masato Sato and
  • Masahiko Watanabe

21 February 2022

Background: Surgical site infection (SSI) is a major complication in spinal instrumentation that is often difficult to treat. The purpose of this study was to identify and determine prognostic indicators for successful treatment of spine instrumentat...

  • Article
  • Open Access
19 Citations
3,423 Views
12 Pages

Combining Hepatic and Splenic CT Radiomic Features Improves Radiomic Analysis Performance for Liver Fibrosis Staging

  • Yunchao Yin,
  • Derya Yakar,
  • Rudi A. J. O. Dierckx,
  • Kim B. Mouridsen,
  • Thomas C. Kwee and
  • Robbert J. de Haas

21 February 2022

Background: The exact focus of computed tomography (CT)-based artificial intelligence techniques when staging liver fibrosis is still not exactly known. This study aimed to determine both the added value of splenic information to hepatic information,...

  • Article
  • Open Access
22 Citations
5,658 Views
15 Pages

Automated Diagnosis of Cervical Intraepithelial Neoplasia in Histology Images via Deep Learning

  • Bum-Joo Cho,
  • Jeong-Won Kim,
  • Jungkap Park,
  • Gui-Young Kwon,
  • Mineui Hong,
  • Si-Hyong Jang,
  • Heejin Bang,
  • Gilhyang Kim and
  • Sung-Taek Park

21 February 2022

Artificial intelligence has enabled the automated diagnosis of several cancer types. We aimed to develop and validate deep learning models that automatically classify cervical intraepithelial neoplasia (CIN) based on histological images. Microscopic...

  • Review
  • Open Access
29 Citations
14,490 Views
21 Pages

21 February 2022

Viral myocarditis is inflammation of the myocardium secondary to viral infection. The clinical presentation of viral myocarditis is very heterogeneous and can range from nonspecific symptoms of malaise and fatigue in subclinical disease to a more flo...

  • Article
  • Open Access
5,151 Views
11 Pages

Interexaminer Reliability and Validity of Quantity of Cervical Mobility during Online Dynamic Inspection

  • Leire Leonet-Tijero,
  • Jaime Corral-de-Toro,
  • Jacobo Rodríguez-Sanz,
  • Mar Hernández-Secorún,
  • Hugo Abenia-Benedí,
  • María Orosia Lucha-López,
  • Sofía Monti-Ballano,
  • Julián Müller-Thyssen-Uriarte,
  • Héctor Tricás-Vidal and
  • José Miguel Tricás-Moreno
  • + 1 author

21 February 2022

Background: Physical therapists routinely measure range of motion (ROM) of cervical spine. The reliability of the cervical range of motion (CROM) device has been demonstrated in several studies, but current evidence on the validity and reliability of...

  • Article
  • Open Access
8 Citations
3,284 Views
11 Pages

Patient-Assessed Outcomes following Temporal Bone Fractures

  • Elias Antoniades,
  • George Psillas,
  • Konstantinos Polyzoidis and
  • Ioannis Patsalas

21 February 2022

The long-term impact of neurotological symptoms after a temporal bone fracture (TBF), including facial nerve palsy (FP), hearing loss, tinnitus, and dizziness on the quality of life of patients is often underevaluated. Thus, we retrospectively assess...

  • Article
  • Open Access
1 Citations
3,229 Views
11 Pages

Left Anterior Sectorectomy: An Alternative to Left Hepatectomy for Tumors Invading the Distal Part of the Left Portal Vein

  • Mattia Garancini,
  • Mauro Alessandro Scotti,
  • Luca Gianotti,
  • Cristina Ciulli,
  • Francesca Carissimi,
  • Fabio Uggeri,
  • Luca Degrate,
  • Marco Braga and
  • Fabrizio Romano

21 February 2022

Background: Liver tumors invading the distal part of the umbilical portion of the left portal vein usually require left hepatectomy. The recent introduction of the concept of left anterior sector, an independent anatomo-functional unit including the...

  • Article
  • Open Access
12 Citations
3,617 Views
12 Pages

Factors Associated with Delirium in COVID-19 Patients and Their Outcome: A Single-Center Cohort Study

  • Annabella Di Giorgio,
  • Antonio Mirijello,
  • Clara De Gennaro,
  • Andrea Fontana,
  • Paolo Emilio Alboini,
  • Lucia Florio,
  • Vincenzo Inchingolo,
  • Michele Zarrelli,
  • Giuseppe Miscio and
  • Maurizio A. Leone
  • + 8 authors

20 February 2022

Background: A significant proportion of patients with coronavirus disease 2019 (COVID-19) suffer from delirium during hospitalization. This single-center observational study investigates the occurrence of delirium, the associated risk factors and its...

  • Review
  • Open Access
8 Citations
3,155 Views
19 Pages

Strain Imaging for the Early Detection of Cardiac Remodeling and Dysfunction in Primary Aldosteronism

  • Yilin Chen,
  • Tingyan Xu,
  • Jianzhong Xu,
  • Limin Zhu,
  • Dian Wang,
  • Yan Li and
  • Jiguang Wang

20 February 2022

Speckle tracking echocardiography is a novel technique to quantify cardiac function and deformation. It has been applied in a series of cardiovascular diseases for the evaluation of early cardiac impairment. We recently used this technique to investi...

  • Case Report
  • Open Access
4 Citations
3,439 Views
7 Pages

20 February 2022

Although radiologic methods confirm the diagnosis of patients with large vestibular schwannomas, these methods usually indicate only the size of the tumor and its possible nerve compression. Electrodiagnostic methods can reveal the functional state o...

  • Article
  • Open Access
14 Citations
4,413 Views
14 Pages

The Role of Early Revascularization and Biomarkers in the Management of Diabetic Foot Ulcers: A Single Center Experience

  • Ettore Dinoto,
  • Francesca Ferlito,
  • Manfredi Agostino La Marca,
  • Graziella Tortomasi,
  • Francesca Urso,
  • Salvatore Evola,
  • Giovanni Guercio,
  • Marco Marcianò,
  • David Pakeliani and
  • Felice Pecoraro
  • + 1 author

19 February 2022

Diabetic neuropathy and Peripheral Arterial Disease (PAD) are the main etiological factors in foot ulceration. Herein, we report our experience of diabetic foot ulceration (DFU) management, with an analysis of the relationship between the rate of low...

  • Systematic Review
  • Open Access
12 Citations
3,977 Views
19 Pages

Evaluation of Diagnostic Performance of Automatic Breast Volume Scanner Compared to Handheld Ultrasound on Different Breast Lesions: A Systematic Review

  • Shahad A. Ibraheem,
  • Rozi Mahmud,
  • Suraini Mohamad Saini,
  • Hasyma Abu Hassan,
  • Aysar Sabah Keiteb and
  • Ahmed M. Dirie

19 February 2022

Objective: To compare the diagnostic performance of the automatic breast volume scanner (ABVS) against the handheld ultrasound (HHUS) in the differential diagnosis of benign and malignant breast lesions. Methods: A systematic search and review of stu...

  • Article
  • Open Access
77 Citations
11,959 Views
19 Pages

Identification of Diabetic Retinopathy Using Weighted Fusion Deep Learning Based on Dual-Channel Fundus Scans

  • Grace Ugochi Nneji,
  • Jingye Cai,
  • Jianhua Deng,
  • Happy Nkanta Monday,
  • Md Altab Hossin and
  • Saifun Nahar

19 February 2022

It is a well-known fact that diabetic retinopathy (DR) is one of the most common causes of visual impairment between the ages of 25 and 74 around the globe. Diabetes is caused by persistently high blood glucose levels, which leads to blood vessel agg...

  • Case Report
  • Open Access
7 Citations
3,162 Views
8 Pages

A Rare Case of Hepatic Vanishing Bile Duct Syndrome Occurring after Combination Therapy with Nivolumab and Cabozantinib in a Patient with Renal Carcinoma

  • Karim Gourari,
  • Julien Catherine,
  • Soizic Garaud,
  • Joseph Kerger,
  • Antonia Lepida,
  • Aspasia Georgala,
  • Fabienne Lebrun,
  • Maria Gomez Galdon,
  • Thierry Gil and
  • Mireille Langouo Fontsa
  • + 1 author

19 February 2022

Tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) significantly improve the outcomes of patients with advanced clear cell renal cell carcinoma (ccRCC); however, high-grade toxicities can occur, particularly during combination...

  • Review
  • Open Access
48 Citations
8,815 Views
21 Pages

Knee Injury Detection Using Deep Learning on MRI Studies: A Systematic Review

  • Athanasios Siouras,
  • Serafeim Moustakidis,
  • Archontis Giannakidis,
  • Georgios Chalatsis,
  • Ioannis Liampas,
  • Marianna Vlychou,
  • Michael Hantes,
  • Sotiris Tasoulis and
  • Dimitrios Tsaopoulos

19 February 2022

The improved treatment of knee injuries critically relies on having an accurate and cost-effective detection. In recent years, deep-learning-based approaches have monopolized knee injury detection in MRI studies. The aim of this paper is to present t...

  • Case Report
  • Open Access
2 Citations
3,073 Views
6 Pages

Testosterone Therapy and Diaphragm Performance in a Male Patient with COVID-19: A Case Report

  • Gloria Martins,
  • Juan Carlos Rosso Verdeal,
  • Helio Tostes,
  • Alice Ramos Oliveira da Silva,
  • Bernardo Tessarollo,
  • Nazareth Novaes Rocha,
  • Patricia Rieken Macedo Rocco and
  • Pedro Leme Silva

19 February 2022

Low levels of testosterone may lead to reduced diaphragm excursion and inspiratory time during COVID-19 infection. We report the case of a 38-year-old man with a positive result on a reverse transcriptase-polymerase chain reaction test for SARS-CoV-2...

  • Article
  • Open Access
16 Citations
6,615 Views
15 Pages

Automated Structural Analysis and Quantitative Characterization of Scar Tissue Using Machine Learning

  • Luluil Maknuna,
  • Hyeonsoo Kim,
  • Yeachan Lee,
  • Yoonjin Choi,
  • Hyunjung Kim,
  • Myunggi Yi and
  • Hyun Wook Kang

19 February 2022

An analysis of scar tissue is necessary to understand the pathological tissue conditions during or after the wound healing process. Hematoxylin and eosin (HE) staining has conventionally been applied to understand the morphology of scar tissue. Howev...

  • Article
  • Open Access
11 Citations
3,751 Views
12 Pages

Understanding Healthcare Professionals’ Perspectives on Point-of-Care Testing

  • Sean Teebagy,
  • Ziyue Wang,
  • Denise Dunlap,
  • Connor Saleeba,
  • Danielle DiMezza,
  • JoAnn Crain,
  • Craig M. Lilly,
  • Bryan Buchholz,
  • David D. McManus and
  • Nathaniel Hafer

19 February 2022

Point-of-care testing (POCT) is an emerging technology that provides crucial assistance in delivering healthcare. The COVID-19 pandemic led to the accelerated importance of POCT technology due to its in-home accessibility. While POCT use and implemen...

  • Article
  • Open Access
44 Citations
9,764 Views
13 Pages

18 February 2022

Age-related macular degeneration (AMD) is a retinal disorder affecting the elderly, and society’s aging population means that the disease is becoming increasingly prevalent. The vision in patients with early AMD is usually unaffected or nearly...

  • Article
  • Open Access
1 Citations
2,661 Views
10 Pages

Radiation Dose and Fluoroscopy Time of Endovascular Coil Embolization in Patients with Carotid Cavernous Fistulas

  • Yigit Ozpeynirci,
  • Christoph Gregor Trumm,
  • Robert Stahl,
  • Thomas Liebig and
  • Robert Forbrig

18 February 2022

Carotid cavernous fistulas (CCFs) are abnormal connections between the cavernous sinus and the internal and/or external carotid artery. Endovascular therapy is the gold standard treatment. In the current retrospective single-center study we report de...

  • Article
  • Open Access
24 Citations
3,810 Views
16 Pages

Lumbar Spine Computed Tomography to Magnetic Resonance Imaging Synthesis Using Generative Adversarial Network: Visual Turing Test

  • Ki-Taek Hong,
  • Yongwon Cho,
  • Chang Ho Kang,
  • Kyung-Sik Ahn,
  • Heegon Lee,
  • Joohui Kim,
  • Suk Joo Hong,
  • Baek Hyun Kim and
  • Euddeum Shim

18 February 2022

(1) Introduction: Computed tomography (CT) and magnetic resonance imaging (MRI) play an important role in the diagnosis and evaluation of spinal diseases, especially degenerative spinal diseases. MRI is mainly used to diagnose most spinal diseases be...

  • Article
  • Open Access
31 Citations
6,736 Views
10 Pages

Digital Pathology Implementation in Private Practice: Specific Challenges and Opportunities

  • Diana Montezuma,
  • Ana Monteiro,
  • João Fraga,
  • Liliana Ribeiro,
  • Sofia Gonçalves,
  • André Tavares,
  • João Monteiro and
  • Isabel Macedo-Pinto

18 February 2022

Digital pathology (DP) is being deployed in many pathology laboratories, but most reported experiences refer to public health facilities. In this paper, we report our experience in DP transition at a high-volume private laboratory, addressing the mai...

  • Review
  • Open Access
13 Citations
6,444 Views
19 Pages

Clinical Applications of Somatostatin Receptor (Agonist) PET Tracers beyond Neuroendocrine Tumors

  • Rasmus Helgebostad,
  • Mona-Elisabeth Revheim,
  • Kjersti Johnsrud,
  • Kristine Amlie,
  • Abass Alavi and
  • James Patrick Connelly

18 February 2022

Somatostatin receptor (SSTR) agonist tracers used in nuclear medicine scans are classically used for neuroendocrine tumor diagnosis and staging. SSTR are however, expressed more widely in a variety of cells as seen in the distribution of physiologica...

  • Article
  • Open Access
5 Citations
4,064 Views
13 Pages

Needle Tip Detection Using Ultrasound Probe for Vertical Punctures: A Simulation and Experimental Study

  • Yuusuke Tanaka,
  • Katsuhiko Tanaka,
  • Hisanori Shiomi,
  • Yoshimasa Kurumi,
  • Tohru Tani and
  • Yukio Ogura

18 February 2022

Current ultrasound-guided punctures are difficult to perform as they are performed at an angle to the ultrasound image of the affected area, resulting in longer puncture times, lower success rates, and higher unexpected injury rates. Vertical punctur...

  • Article
  • Open Access
15 Citations
4,010 Views
9 Pages

EVAR Follow-Up with Ultrasound Superb Microvascular Imaging (SMI) Compared to CEUS and CT Angiography for Detection of Type II Endoleak

  • Marco Curti,
  • Filippo Piacentino,
  • Federico Fontana,
  • Christian Ossola,
  • Andrea Coppola,
  • Paolo Marra,
  • Antonio Basile,
  • Anna Maria Ierardi,
  • Gianpaolo Carrafiello and
  • Massimo Venturini
  • + 3 authors

18 February 2022

The aim of this study was to evaluate the usefulness of superb microvascular imaging (SMI) versus contrast-enhanced ultrasound (CEUS) and compared to computed tomography angiography (CTA) as a reference standard, for detection of type II endoleak dur...

  • Article
  • Open Access
11 Citations
2,969 Views
11 Pages

18 February 2022

The aim of this paper was to assess the associations between prostate cancer aggressiveness and histogram-derived apparent diffusion coefficient (ADC) parameters and determine which ADC parameters may help distinguish among stromal hyperplasia (SH),...

  • Article
  • Open Access
5 Citations
3,110 Views
17 Pages

Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria

  • Bernard Tornyigah,
  • Samuel Odarkwei Blankson,
  • Rafiou Adamou,
  • Azizath Moussiliou,
  • Lauriane Rietmeyer,
  • Patrick Tettey,
  • Liliane Dikroh,
  • Bernard Addo,
  • Helena Lamptey and
  • Rachida Tahar
  • + 7 authors

18 February 2022

Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concen...

  • Article
  • Open Access
5 Citations
3,275 Views
10 Pages

18 February 2022

Purpose: To evaluate the diagnostic performance of ultrasound point shear wave elastography (pSWE) using acoustic radiation force impulse (ARFI) technology in different benign and malignant mesenteric masses (MMs). Methods: A total of 69 patients wit...

  • Article
  • Open Access
69 Citations
5,543 Views
13 Pages

Quantum Iterative Reconstruction for Low-Dose Ultra-High-Resolution Photon-Counting Detector CT of the Lung

  • Thomas Sartoretti,
  • Damien Racine,
  • Victor Mergen,
  • Lisa Jungblut,
  • Pascal Monnin,
  • Thomas G. Flohr,
  • Katharina Martini,
  • Thomas Frauenfelder,
  • Hatem Alkadhi and
  • André Euler

18 February 2022

The aim of this study was to characterize image quality and to determine the optimal strength levels of a novel iterative reconstruction algorithm (quantum iterative reconstruction, QIR) for low-dose, ultra-high-resolution (UHR) photon-counting detec...

  • Correction
  • Open Access
1,528 Views
1 Page

Correction: Ferraz-Amaro et al. SCORE2 Assessment in The Calculation of Cardiovascular Risk in Patients with Rheumatoid Arthritis. Diagnostics 2021, 11, 2363

  • Iván Ferraz-Amaro,
  • Alfonso Corrales,
  • Belén Atienza-Mateo,
  • Nuria Vegas-Revenga,
  • Diana Prieto-Peña,
  • Julio Sánchez-Martín,
  • Cristina Almeida,
  • Juan Carlos Quevedo-Abeledo,
  • Ricardo Blanco and
  • Miguel Á. González-Gay

18 February 2022

In the original article [...]

  • Article
  • Open Access
3 Citations
3,107 Views
9 Pages

Negative Venous Leg Ultrasound in Acute Pulmonary Embolism: Prevalence, Clinical Characteristics and Predictors

  • Mattes Becher,
  • Thomas Heller,
  • Sarah Schwarzenböck,
  • Jens-Christian Kröger,
  • Marc-André Weber and
  • Felix G. Meinel

17 February 2022

The purpose of this study was to investigate the prevalence, clinical characteristics, and predictors of negative venous leg ultrasound in acute pulmonary embolism (PE). We retrospectively analyzed a cohort of 168 patients with acute PE (median age 7...

  • Article
  • Open Access
4 Citations
9,628 Views
18 Pages

Pelvic Sidewall Anatomy in Gynecologic Oncology—New Insights into a Potential Avascular Space

  • Stoyan Kostov,
  • Ilker Selçuk,
  • Rafał Watrowski,
  • Yavor Kornovski,
  • Hakan Yalçın,
  • Stanislav Slavchev,
  • Yonka Ivanova,
  • Deyan Dzhenkov and
  • Angel Yordanov

17 February 2022

The surgical treatment of gynecological malignancies is, except for tumors diagnosed at the earliest stages and patients’ desire for fertility preservation, not limited to only the affected organ. In cases of metastatic iliac lymph nodes, gynec...

  • Article
  • Open Access
69 Citations
7,450 Views
19 Pages

17 February 2022

Autism spectrum disorder is a group of disorders marked by difficulties with social skills, repetitive activities, speech, and nonverbal communication. Deficits in paying attention to, and processing, social stimuli are common for children with autis...

  • Article
  • Open Access
12 Citations
3,395 Views
14 Pages

The Prognostic Value of Anemia in Patients with Preserved, Mildly Reduced and Recovered Ejection Fraction

  • Anita Pintér,
  • Anett Behon,
  • Boglárka Veres,
  • Eperke Dóra Merkel,
  • Walter Richard Schwertner,
  • Luca Katalin Kuthi,
  • Richard Masszi,
  • Bálint Károly Lakatos,
  • Attila Kovács and
  • Annamária Kosztin
  • + 2 authors

17 February 2022

Data on the relevance of anemia in heart failure (HF) patients with an ejection fraction (EF) > 40% by subgroup—preserved (HFpEF), mildly reduced (HFmrEF) and the newly defined recovered EF (HFrecEF)—are scarce. Patients with HF sympto...

  • Article
  • Open Access
13 Citations
3,193 Views
12 Pages

Critical Illness Polyneuropathy and Myopathy and Clinical Detection of the Recovery of Consciousness in Severe Acquired Brain Injury Patients with Disorders of Consciousness after Rehabilitation

  • Bahia Hakiki,
  • Francesca Cecchi,
  • Silvia Pancani,
  • Anna Maria Romoli,
  • Francesca Draghi,
  • Maenia Scarpino,
  • Raisa Sterpu,
  • Andrea Mannini,
  • Claudio Macchi and
  • Antonello Grippo

17 February 2022

Background: Disorders of consciousness (DoCs) include unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Critical illness polyneuropathy and myopathy (CIPNM) is frequent in severe acquired brain injuries and impacts function...

  • Case Report
  • Open Access
10 Citations
6,303 Views
5 Pages

SARS-CoV-2 Viral RNA Is Detected in the Bone Marrow in Post-Mortem Samples Using RT-LAMP

  • Tomasz Jurek,
  • Marta Rorat,
  • Łukasz Szleszkowski,
  • Miron Tokarski,
  • Izabela Pielka and
  • Małgorzata Małodobra-Mazur

17 February 2022

Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, viral RNA has been detected in several different human tissues and organs. This study reports the detection of SARS-CoV-2 RNA in the bone marrow. Post-m...

  • Article
  • Open Access
5 Citations
5,022 Views
13 Pages

Evaluation of a Whole-Liver Dixon-Based MRI Approach for Quantification of Liver Fat in Patients with Type 2 Diabetes Treated with Two Isocaloric Different Diets

  • Valentina Brancato,
  • Giuseppe Della Pepa,
  • Lutgarda Bozzetto,
  • Marilena Vitale,
  • Giovanni Annuzzi,
  • Luca Basso,
  • Carlo Cavaliere,
  • Marco Salvatore,
  • Angela Albarosa Rivellese and
  • Serena Monti

16 February 2022

Dixon-based methods for the detection of fatty liver have the advantage of being non-invasive, easy to perform and analyze, and to provide a whole-liver coverage during the acquisition. The aim of the study was to assess the feasibility of a whole-li...

  • Review
  • Open Access
9 Citations
10,873 Views
15 Pages

16 February 2022

In patients with acute circulatory failure, fluid administration represents a first-line therapeutic intervention for improving cardiac output. However, only approximately 50% of patients respond to fluid infusion with a significant increase in cardi...

  • Review
  • Open Access
12 Citations
11,012 Views
15 Pages

Role of EBUS-TBNA in Non-Neoplastic Mediastinal Lymphadenopathy: Review of Literature

  • Valentina Scano,
  • Alessandro Giuseppe Fois,
  • Andrea Manca,
  • Francesca Balata,
  • Angelo Zinellu,
  • Carla Chessa,
  • Pietro Pirina and
  • Panos Paliogiannis

16 February 2022

Mediastinal lymphadenopathy is a condition in which one or more mediastinal lymph nodes are enlarged for malignant or benign causes, generally more than 10 mm. For a long time, the only way to approach the mediastinum was surgery, while in last decad...

  • Article
  • Open Access
1 Citations
4,470 Views
10 Pages

16 February 2022

Background: We investigated the clinical signs to establish a method for rapid identification of patients with the National Institute of Health Stroke Scale (NIHSS) score ≥ 8 eligible for direct brain CTA study; Methods: We retrospectively enrolle...

  • Article
  • Open Access
6 Citations
4,821 Views
9 Pages

Visual Assessment of Blood Plasma versus Optical Transmittance and Refractive Index Measurements for Quantifying Lipemia

  • Roberto Márquez-Islas,
  • Argelia Pérez-Pacheco,
  • Rosa Quispe-Siccha,
  • Laura Beatriz Salazar-Nieva and
  • Augusto García-Valenzuela

16 February 2022

Today, visual classification of the degree of lipemia in blood samples is frequently performed in clinical laboratories. However, achieving standardization of this classification at low cost and with fewer resources is an objective that is still unde...

  • Review
  • Open Access
29 Citations
5,908 Views
16 Pages

Biomarkers during COVID-19: Mechanisms of Change and Implications for Patient Outcomes

  • Cheng-Han Chen,
  • Sheng-Wen Lin,
  • Ching-Fen Shen,
  • Kai-Sheng Hsieh and
  • Chao-Min Cheng

16 February 2022

As the COVID-19 (Coronavirus disease 19) pandemic spreads worldwide, the massive numbers of COVID-19 patients have created a considerable healthcare burden for every country. The clinical spectrum of SARS-CoV-2 infection is broad, ranging from asympt...

  • Review
  • Open Access
92 Citations
38,606 Views
23 Pages

Evolution of Diagnostic Methods for Helicobacter pylori Infections: From Traditional Tests to High Technology, Advanced Sensitivity and Discrimination Tools

  • Alexandra Ioana Cardos,
  • Adriana Maghiar,
  • Dana Carmen Zaha,
  • Ovidiu Pop,
  • Luminita Fritea,
  • Florina Miere (Groza) and
  • Simona Cavalu

16 February 2022

Rapid diagnosis and treatment application in the early stages of H. pylori infection plays an important part in inhibiting the transmission of this infection as this bacterium is involved in various gastric pathologies such as gastritis, gastro-duode...

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Diagnostics - ISSN 2075-4418