Ovarian Cancer 3.0: Characteristics, Screening, Diagnosis and Treatment

Dear Colleagues,

Ovarian cancer is deadly, claiming more women than all other gynecological malignancies combined. However, when detected at an early stage, ovarian cancer is highly curable. Consequently, screening efforts are likely to be the best way to detect early stage disease. The forthcoming Special Issue focuses on several key elements that are essential for an understanding of ovarian cancer, its characteristics, and risk factors that are relevant to screening for ovarian cancer. Invited topics are the following:

1. Risk factors for ovarian cancer
2. Markers and new genes associated with ovarian cancer
3. Ovarian cancer subtypes and their relatedness
4. Treatment related to high volume centers and National Comprehensive Cancer Network guidelines
5. Predictors of treatment responses
6. Treatment costs and effectiveness
7. Therapies and precision therapies for ovarian cancer
8. Vaccines and checkpoints in the immune therapy of ovarian cancer
9. Diagnostic tools: Strengths and limitations
10. International variations in ovarian cancer diagnosis and treatment
11. Determining ovarian cancer risk by tests for the general population
12. Mitigating risk of ovarian cancer surgically or medically
13. Screening trial design: Selection, make-up, execution, protocol driven aspects, age of participants, duration of screening, follow-up and events to be censored
14. Collateral affectors in screening: Perceptions of well-being and potential complications of treatment as confounders of compliance
15. Endpoints and efficacy: Early stage detection, disease specific survival, overall survival and avoidance of an ovarian cancer death as endpoints, with considerations of screen performance and cost
16. Interpretation of ovarian screening trials. Comparisons between screening trials conducted in the United States, the United Kingdom and Japan are informative regarding the current status of ovarian screening

Dr. Edward J. Pavlik
Guest Editor

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