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Diagnostics, Volume 11, Issue 2

February 2021 - 235 articles

Cover Story: Metabolic acidosis is a common disorder in CKD patients. Under physiological conditions, arterial bicarbonate level is higher in arterial than in venous blood due to the production of endogenous acids in tissues. In the lungs, bicarbonate is regenerated. We found that arteriovenous gradient of bicarbonate (AVΔ-HCO3−) positively correlated with eGFR. In patients with advanced CKD, there is practically no arteriovenous difference in bicarbonate concentration. The value of AVΔ-HCO3− may facilitate decision of bicarbonate supplementation or renal replacement therapy start in doubtful situations. View this paper.
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Articles (235)

  • Article
  • Open Access
28 Citations
4,493 Views
16 Pages

Acceptability and Usability of HCV Self-Testing in High Risk Populations in Vietnam

  • Linh Thuy Nguyen,
  • Van Thi Thuy Nguyen,
  • Kim Anh Le Ai,
  • Minh Binh Truong,
  • Tam Thi Minh Tran,
  • Muhammad S. Jamil,
  • Cheryl Johnson,
  • Elena Ivanova Reipold,
  • Philippa Easterbrook and
  • Kidong Park

23 February 2021

HIV self-testing has emerged as a safe and effective approach to increase the access to and uptake of HIV testing and treatment, especially for key populations. Applying self-testing to hepatitis C virus (HCV) may also offer an additional way to addr...

  • Systematic Review
  • Open Access
27 Citations
13,139 Views
17 Pages

Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment

  • Alba Scerrati,
  • Erica Menegatti,
  • Matilde Zamboni,
  • Anna Maria Malagoni,
  • Mirko Tessari,
  • Roberto Galeotti and
  • Paolo Zamboni

23 February 2021

(1) Background: internal jugular vein thrombosis (IJVthr) is a potentially life-threating disease but no comprehensive reviews on etiology, symptomatology, diagnosis and current treatment guidelines are yet available; (2) Methods: we prospectively de...

  • Review
  • Open Access
20 Citations
3,500 Views
16 Pages

Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations

  • Olivier Chevallier,
  • Yì Xiáng J. Wáng,
  • Kévin Guillen,
  • Julie Pellegrinelli,
  • Jean-Pierre Cercueil and
  • Romaric Loffroy

23 February 2021

Diffusion weighted imaging (DWI) and intravoxel incoherent motion (IVIM) have been explored to assess liver tumors and diffused liver diseases. IVIM reflects the microscopic translational motions that occur in voxels in magnetic resonance (MR) DWI. I...

  • Review
  • Open Access
52 Citations
5,685 Views
29 Pages

A Systematic Review of PET Textural Analysis and Radiomics in Cancer

  • Manuel Piñeiro-Fiel,
  • Alexis Moscoso,
  • Virginia Pubul,
  • Álvaro Ruibal,
  • Jesús Silva-Rodríguez and
  • Pablo Aguiar

23 February 2021

Background: Although many works have supported the utility of PET radiomics, several authors have raised concerns over the robustness and replicability of the results. This study aimed to perform a systematic review on the topic of PET radiomics and...

  • Review
  • Open Access
1 Citations
3,812 Views
7 Pages

23 February 2021

Human pulmonary circulation is as full of mysteries and surprises as is the history of attempts to uncover and understand them. The Special Issue of Diagnostics, appearing after 2020 immobilized the world, give us an opportunity, space and momentum t...

  • Article
  • Open Access
13 Citations
3,601 Views
13 Pages

Wnt/β-Catenin Signaling Regulates CXCR4 Expression and [68Ga] Pentixafor Internalization in Neuroendocrine Tumor Cells

  • Alexander Weich,
  • Dorothee Rogoll,
  • Sophia Gawlas,
  • Lars Mayer,
  • Wolfgang Weich,
  • Judit Pongracz,
  • Theodor Kudlich,
  • Alexander Meining and
  • Michael Scheurlen

22 February 2021

Loss of Somatostatin Receptor 2 (SSTR2) expression and rising CXC Chemokine Receptor Type 4 (CXCR4) expression are associated with dedifferentiation in neuroendocrine tumors (NET). In NET, CXCR4 expression is associated with enhanced metastatic and i...

  • Article
  • Open Access
10 Citations
2,992 Views
11 Pages

MR-Imaging and Histopathological Diagnostic Work-Up of Patients with Spontaneous Lobar Intracerebral Hemorrhage: Results of an Institutional Prospective Registry Study

  • Patrick Schuss,
  • Christian Bode,
  • Valeri Borger,
  • Christoph Coch,
  • Ági Güresir,
  • Alexis Hadjiathanasiou,
  • Motaz Hamed,
  • Klaus Kuchelmeister,
  • Felix Lehmann and
  • Marcus Müller
  • + 5 authors

22 February 2021

Intracerebral hemorrhage (ICH) is a frequently disabling or fatal disease. The localization of ICH often allows an etiological association. However, in atypical/lobar ICH, the cause of bleeding is less obvious. Therefore, we present prospective histo...

  • Article
  • Open Access
46 Citations
5,336 Views
14 Pages

A Multi-Center, Multi-Vendor Study to Evaluate the Generalizability of a Radiomics Model for Classifying Prostate cancer: High Grade vs. Low Grade

  • Jose M. Castillo T.,
  • Martijn P. A. Starmans,
  • Muhammad Arif,
  • Wiro J. Niessen,
  • Stefan Klein,
  • Chris H. Bangma,
  • Ivo G. Schoots and
  • Jifke F. Veenland

22 February 2021

Radiomics applied in MRI has shown promising results in classifying prostate cancer lesions. However, many papers describe single-center studies without external validation. The issues of using radiomics models on unseen data have not yet been suffic...

  • Article
  • Open Access
3 Citations
2,855 Views
10 Pages

Local Laboratory Testing of Germline BRCA Mutations vs. Myriad: A Single-Institution Experience in Korea

  • Joohyun Hong,
  • Jiyun Lee,
  • Minsuk Kwon,
  • Ji-Yeon Kim,
  • Jong-Won Kim,
  • Jin Seok Ahn,
  • Young-Hyuck Im and
  • Yeon Hee Park

22 February 2021

Genetic diagnosis for human epidermal growth factor receptor 2-negative metastatic breast cancer patients with the germline BRCA (gBRCA) mutation has been emphasized since the development of polyadenosine diphosphate-ribose polymerase inhibitors. Myr...

  • Review
  • Open Access
35 Citations
6,966 Views
22 Pages

22 February 2021

Many neurodegenerative diseases present with progressive neuronal degeneration, which can lead to cognitive and motor impairment. Early screening and diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD...

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Diagnostics - ISSN 2075-4418