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Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations

1
Image-Guided Therapy Center, Department of Vascular and Interventional Radiology, François-Mitterrand University Hospital, 14 Rue Paul Gaffarel, BP 77908, 21079 Dijon, France
2
Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Palmucci
Diagnostics 2021, 11(2), 379; https://doi.org/10.3390/diagnostics11020379
Received: 28 January 2021 / Revised: 14 February 2021 / Accepted: 20 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Sequences and Contrast Agents for Quantitative MRI)
Diffusion weighted imaging (DWI) and intravoxel incoherent motion (IVIM) have been explored to assess liver tumors and diffused liver diseases. IVIM reflects the microscopic translational motions that occur in voxels in magnetic resonance (MR) DWI. In biologic tissues, molecular diffusion of water and microcirculation of blood in the capillary network can be assessed using IVIM DWI. The most commonly applied model to describe the DWI signal is a bi-exponential model, with a slow compartment of diffusion linked to pure molecular diffusion (represented by the coefficient Dslow), and a fast compartment of diffusion, related to microperfusion (represented by the coefficient Dfast). However, high variance in Dfast estimates has been consistently shown in literature for liver IVIM, restricting its application in clinical practice. This variation could be explained by the presence of another very fast compartment of diffusion in the liver. Therefore, a tri-exponential model would be more suitable to describe the DWI signal. This article reviews the published evidence of the existence of this additional very fast diffusion compartment and discusses the performance and limitations of the tri-exponential model for liver IVIM in current clinical settings. View Full-Text
Keywords: diffusion weighted imaging; intravoxel incoherent motion; liver; tri-exponential; b-value diffusion weighted imaging; intravoxel incoherent motion; liver; tri-exponential; b-value
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MDPI and ACS Style

Chevallier, O.; Wáng, Y.X.J.; Guillen, K.; Pellegrinelli, J.; Cercueil, J.-P.; Loffroy, R. Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations. Diagnostics 2021, 11, 379. https://doi.org/10.3390/diagnostics11020379

AMA Style

Chevallier O, Wáng YXJ, Guillen K, Pellegrinelli J, Cercueil J-P, Loffroy R. Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations. Diagnostics. 2021; 11(2):379. https://doi.org/10.3390/diagnostics11020379

Chicago/Turabian Style

Chevallier, Olivier; Wáng, Yì X.J.; Guillen, Kévin; Pellegrinelli, Julie; Cercueil, Jean-Pierre; Loffroy, Romaric. 2021. "Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations" Diagnostics 11, no. 2: 379. https://doi.org/10.3390/diagnostics11020379

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