Next Article in Journal
Endometrium-Limited Metastasis of Extragenital Malignancies: A Challenge in the Diagnosis of Endometrial Curettage Specimens
Next Article in Special Issue
Triple Metachronous Malignancies with Thyroid Involvement: A Brief Overview of Five Case Reports over 20 Years of Institutional Experience
Previous Article in Journal
Can Strain Elastography Predict Malignancy of Soft Tissue Tumors in a Tertiary Sarcoma Center?
Previous Article in Special Issue
Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 10
Issue 3
10.3390/diagnostics10030149
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review

by
Dragos Apostu
1,†,
Ondine Lucaciu
2,*,†,
Daniel Oltean-Dan
1,
Alexandru-Dorin Mureșan
3,
Cristina Moisescu-Pop
4,
Andrei Maxim
1 and
Horea Benea
1,†
1
Department of Orthopedics and Traumatology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400132, Romania
2
Department of Oral Health, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400012, Romania
3
Department of Sport and Physical Education Science, University of Babes-Bolyai, Cluj-Napoca 400376, Romania
4
Nuclear Medicine Department, “Prof. Dr. Ioan Chiricuța” Institute of Oncology, Cluj-Napoca 400015, Romania
*
Author to whom correspondence should be addressed.
†
These authors contribute equally to this manuscript.
Diagnostics 2020, 10(3), 149; https://doi.org/10.3390/diagnostics10030149
Submission received: 8 February 2020 / Revised: 26 February 2020 / Accepted: 2 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue New Insights in Thyroid Diagnostics)
Browse Figure
Review Reports Versions Notes

Abstract

:
Thyroid hormones are important factors that regulate metabolism and cell differentiation throughout the human body. A complication of thyroid pathology is represented by an alteration of the bone metabolism which can lead to osteoporosis and fragility fractures, known to have a high mortality rate. Although there is a consensus on the negative impact of hyperthyroidism on bone metabolism, when referring to hypothyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism, there is no general agreement. The aim of our review was to update clinicians and researchers about the current data regarding the bone health in hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism patients. Thyroid disorders have an important impact on bone metabolism and fracture risk, such that hyperthyroidism, hypothyroidism, and subclinical hyperthyroidism are associated with a decreased bone mineral density (BMD) and increased risk of fracture. Subclinical hypothyroidism, on the other hand, is not associated with osteoporosis or fragility fractures, and subclinical hyperthyroidism treatment with radioiodine could improve bone health.

1. Introduction

Thyroid hormones are important factors which regulate metabolism and cell differentiation throughout the human body. Their receptors are localized in the nervous system, pituitary gland, lungs, heart, liver, muscle, bones, testis, placenta, and other tissues. Therefore, their increase or decrease has an impact on the whole body. These changes in thyroid hormone levels occur in hypothyroidism, hyperthyroidism, as well as subclinical hypothyroidism and subclinical hyperthyroidism. An important effect is represented by changes in bone metabolism, which frequently leads to a decreased bone mineral density called osteoporosis. This complication can lead to an increased risk of fragility fractures, usually associated with a high risk of mortality within the first year. These effects appearing on the bone tissue have been well documented in the case of hyperthyroidism. On the other hand, there is no consensus when referring to hypothyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism. The aim of our review is to update clinicians and researchers about the current data regarding the bone health in hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism patients. Moreover, it will discuss the treatment options in such cases.

2. Materials and Methods

We have searched the PubMed database for the following keywords: “hypothyroidism osteoporosis”, “hypothyroidism fracture”, “hypothyroidism bone”, “subclinical hypothyroidism osteoporosis”, “subclinical hypothyroidism fracture”, “subclinical hypothyroidism bone”, “subclinical hyperthyroidism osteoporosis”, “subclinical hyperthyroidism fracture”, “subclinical hyperthyroidism bone”, ‘’autoimmune thyroid bone metabolism”, ‘’autoimmune thyroid bone mineral density”, ‘’autoimmune thyroid osteoporosis”, ‘’autoimmune thyroid fracture”, “Hashimoto osteoporosis”, and ‘’Hashimoto fracture”. We have included clinical trials and meta-analyses from 2002 until 2020. The bone studies reviewed in our study included dual-energy X-ray absorptiometry (DXA) scan, bone turnover markers and Fracture Risk Assessment Tool (FRAX) score. From a total of 3505 articles, only 41 fulfilled our inclusion criteria.

3. Bone Health

Osteoporosis is represented by a low bone mass and it is defined as the bone mineral density of 2.5 standard deviations of that of young adults (T-score), measured using a dual-energy X-ray absorptiometry (DEXA) [1]. It is the result of an imbalance between the processes of bone resorption and bone formation. It has a high incidence in the general population, such that up to 50% of post-menopausal women are affected by osteoporosis [2]. Osteoporosis can be either primary or secondary. For primary, the causes are age and menopause [3]. Secondary causes are numerous and they include liver disease, renal failure, rheumatoid arthritis, chronic obstructive pulmonary disease, endocrine disorders, gastrointestinal disorders, hematologic disorders, nutrition disorders, central nervous system disorders, human immunodeficiency virus infection, systemic lupus erythematosus, and diverse medications [3,4,5]. In the United States, women over 65 years old or those with an increased fracture risk using FRAX score are recommended to be screened for osteoporosis [3]. Clinically, osteoporosis has no symptoms, but it can lead to loss of height, back pain, change in posture or intense pain following a fracture, as it increases the fracture risk by two-fold for every standard deviation below the mean of a young adult [2,6].
Regarding the complications of osteoporosis, the most frequent osteoporotic fractures are vertebral, where two-thirds are asymptomatic, followed by distal radius and hip fractures [6]. It is considered that 30–40% of people with osteoporosis will have an osteoporotic fracture during their lives [1]. This is important, as vertebral and hip fractures are life-threatening pathologies in the elderly population.
Following the diagnosis of osteoporosis, patients are recommended supplement intake such as calcium at a daily dose of 1000 mg for men aged 50–70 years and 1200 mg for men aged over 70 years and women over 50 years old [1]. Moreover, vitamin D intake is also needed at a dose of 600 IU/day until 70 years old and 800 IU/day afterward [1]. Preferably, the quantity of vitamin D should be adjusted according to the serum 25 (OH) D levels [1]. Other management strategies for osteoporotic patients in order to reduce the fracture risk include the decrease of alcohol consumption, less than two servings of caffeine drinks daily, beginning a regular physical exercise program, and fall-prevention programs.

4. Physiopathology of Thyroid’s Effect on Bone Metabolism

The bone remodeling cycle is a key element for the bone changes found in thyroid pathology. The bone undergoes a continuous process of bone formation and bone resorption throughout the lifetime, called the bone remodeling cycle [7]. The bone remodeling process is started by osteoclasts, which are osteoblast-derived cells. They are connected to each other by a dendritic network and initiate the bone resorption performed by osteoclasts. After the osteoclasts finish the osteolytic process, osteoblasts perform bone formation at the site. Apart from local factors, the bone remodeling process is regulated by systemic factors such as calcitonin, parathyroid hormone, vitamin D3, estrogen, thyroid hormone, glucocorticoids, and growth hormones [8].
The T3 hormone acts on TRα receptors on both osteoblasts and osteoclasts (Figure 1) [9]. On osteoblasts, it is considered to increase osteoblast formation and bone formation, while on the osteoclasts it could increase osteoclast formation and the bone resorption process (Figure 1) [9]. It is not yet clear whether T3 acts on osteoclasts directly or indirectly using the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) pathway (Figure 1) [9]. The pituitary gland can also act directly on the bone cells by thyroid-stimulating hormone (TSH) action on the TSH receptor (TSHR) found in both osteoblasts and osteoclasts, in a similar manner to T3 [9,10].
The literature shows that the normal bone remodeling cycle of approximately 200 days is reduced to almost 100 days in the case of hyperthyroidism and increased to approximately 700 days in the case of hypothyroidism [11]. Some data support the idea that hyperthyroidism reduces bone mineral density by almost 10% for every bone remodeling cycle, while hypothyroidism increases bone mineral density by almost 17% for every bone remodeling cycle [11]. The lower bone mass found in hyperthyroidism results in an increased risk of fractures [10]. On the other hand, although the bone mass is considered to be increased in hypothyroidism by some studies, the fracture risk is increased due to increased stiffness of the bone [10].
Hyperthyroidism is generally accepted to decreases bone mineral density (BMD) and increases the risk of fractures. On the other hand, clinicians have different opinions on the impact of hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on bone pathology.
Thyroid disorders can lead to osteoporosis and increase the risk of fractures. Hip fractures are an important cause of presentation in the emergency departments worldwide and are associated with an increased cost [12]. Most importantly, hip fractures cause a reduction of functional status, a decrease in mobility, and a decrease in social independence [12]. Furthermore, these fractures are associated with an increased risk of mortality, ranging between 9.7% to 34.8% in the first year following the traumatism [12]. Therefore, any effort to reduce the incidence of hip fractures by limiting the reduction of bone mineral density is important for patients with associated thyroid pathologies.
We reviewed the PubMed database from 2002 to 2020 in search of clinical studies on the impact of hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on bone metabolism and incidence of fragility fractures (Table 1, Table 2 and Table 3).

5. Thyroid Pathology

Hypothyroidism is represented by thyroid hormone deficiency and it is a common pathology worldwide, with a prevalence of up to 7% in the general population [47]. The causes of hypothyroidism can be divided into primary, central, and peripheral [47]. Primary hypothyroidism is represented by thyroid hormone deficiency and includes chronic autoimmune thyroiditis as well as iodine deficiency or radioiodine treatment. Central hypothyroidism is represented by thyroid stimulating hormone (TSH) deficiency or by thyrotropin-releasing hormone (TRH) deficiency and includes pituitary tumors, pituitary dysfunction, or hypothalamic dysfunction. Peripheral hypothyroidism is represented by the peripheral resistance to thyroid hormones and includes decreased sensitivity to thyroid hormones and consumptive hypothyroidism [47].
Diagnosis of hypothyroidism requires examining the levels of thyroid-stimulating hormone (TSH) and free thyroxine. If the TSH level is above the normal range, while the free thyroxine (FT4) level is below the normal range, then primary hypothyroidism is diagnosed. When central hyperthyroidism (both secondary and tertiary hypothyroidism) is present, the TSH level can be either normal or low, while the FT4 level is low. Peripheral hypothyroidism is a congenital disorder and is not the subject of our research.
The current treatment of hypothyroidism is represented by levothyroxine monotherapy. The dose is adjusted until TSH levels are normalized [47]. Additionally, a levothyroxine–liothyronine combination therapy can be used in some subgroups of patients [47].
Complications of hypothyroidism include goiter, cardiovascular disease, myxedema, infertility, and mental health issues.
Subclinical hypothyroidism is a mild form of hypothyroidism defined as a higher TSH level with a normal serum free thyroxine (FT4) level [48]. It is thought that over 20% of women over the age of 75 years present with this condition [48]. Causes of subclinical hypothyroidism include autoimmune thyroiditis, radioiodine treatment, subtotal thyroidectomy, subacute thyroiditis, drug-induced, and TSH receptor [48]. Subclinical hypothyroidism is more likely to present fatigue compared to euthyroid patients [48]. A review showed associations between subclinical hypothyroidism and coronary heart disease in younger patients with high TSH levels, cardiac failure in patients with TSH > 10 mIU/L, cerebrovascular disease in younger patients with high TSH levels, adverse lipid profiles, and type 2 diabetes [48]. No association was found between subclinical hypothyroidism and impaired cognition, frailty, and neuropsychological function [48]. There is currently no consensus on whether subclinical hypothyroidism should be treated [48].
Subclinical hyperthyroidism is the mild form of hyperthyroidism and it is defined as a low TSH level associated with normal levels of free thyroxine (FT4) and free triiodothyronine (FT3) [49]. It can be caused by Graves’ disease, multinodular toxic goiter, autonomous functioning thyroid adenoma, or an iatrogenic condition in differentiated thyroid carcinoma [49,50,51]. Subclinical hyperthyroidism increases the risk of atrial fibrillation, heart failure, and overall mortality (especially if TSH levels are <0.1 mIU/L) [49]. Treatment is recommended in patients with TSH < 0.1 mIU/L and aged 65 or older, with heart disease, hyperthyroid symptoms, osteoporosis, or post-menopausal. In the case of a TSH level between 0.1 and 0.4 mIU/L and the mentioned comorbidities, the treatment is controversial [49].
Hypothyroidism and bone health. Hypothyroidism has been shown to decrease BMD in the majority of studies. TSH values both above and below the reference values have been shown to decrease the BMD (Table 1, Table 2 and Table 3) [14,16,17,32,33]. Only one prospective study performed by Tuchendler and Bolanowski in 2013 using 119 participants did not show a negative effect on BMD in the case of hypothyroidism, except in the case of hyperthyroidism (Table 1, Table 2 and Table 3) [15]. Regarding the incidence of fracture risk in hypothyroidism patients, we found two studies using 92,341 and 16,249 patients, that showed a higher incidence of fractures in these patients (Table 1, Table 2 and Table 3) [34,35]. As a result, we believe hypothyroidism should be considered a risk factor for osteoporotic fractures.
Can the treatment of hypothyroidism reverse the negative effect on bone? Studies have shown that hypothyroidism overtreatment with levothyroxine is the main negative factor on bone metabolism and fracture risk (Table 1, Table 2 and Table 3) [19,36]. A study concluded that only levothyroxine treatment is associated with a lower BMD in hypothyroid patients, and also showed that TSH levels in these patients were between 0.1 mIU/L to 2.1 IU/L and overtreatment was the only risk of lower BMD (Table 1, Table 2 and Table 3) [20]. We did not find data regarding whether a correctly balanced treatment of hypothyroidism can reverse the negative effects on bone.
Autoimmune thyroid disease and bone health. Hashimoto disease can have a unique impact on the the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) system, apart from the hypothyroidism, potentially leading to additional bone loss [21]. The presence of thyroid peroxidase antibodies (TPOAb) can be a marker of increased fracture risk in euthyroid post-menopausal women [37,38].
Subclinical hypothyroidism and bone health. Although previous studies have shown that subclinical hypothyroidism has a reduced BMD and an increased risk of fracture, more recent data contradict those findings (Table 1, Table 2 and Table 3) [33,34,35,36,37]. Since 2014, all of the studies, both prospective and retrospective, have shown no influence of subclinical hypothyroidism on either BMD or fracture risk (Table 1, Table 2 and Table 3) [25,26,41,42,43]. We can conclude that recent data do not support any impact of subclinical hypothyroidism on osteoporosis or fragility fractures.
The same results were obtained in the case of subclinical hypothyroidism treatment with levothyroxine. Newer prospective data contradict previous studies and conclude that treatment with levothyroxine does not affect bone health (Table 1, Table 2 and Table 3) [27,28,29,30].
Subclinical hyperthyroidism and bone health. Subclinical hyperthyroidism is considered by most studies to be associated with a lower BMD and with an increased risk of fracture (Table 1, Table 2 and Table 3) [25,40,42,44,45,46]. Only a few studies showed that subclinical hyperthyroidism is not predictive for incidental hip fracture (Table 1, Table 2 and Table 3) [23,40]. From above results, subclinical hyperthyroidism may be associated with a higher risk of fractures compared to euthyroid patients.
We found only one study to test the impact of radioiodine therapy in the case of subclinical hyperthyroidism (Table 1, Table 2 and Table 3) [29]. It concluded that radioiodine has beneficial effects on BMD, but we believe that more data are needed in order to support the conclusion (Table 1, Table 2 and Table 3) [31].

6. Conclusions

Osteoporosis and fragility fractures are important complications of thyroid disorders, associated with increased mortality. Thyroid disorders have an important impact on bone metabolism and fracture risk, as hyperthyroidism and subclinical hyperthyroidism are associated with a decreased BMD and increased risk of fracture. Hypothyroidism overtreatment with levothyroxine has a similar impact on bone health as hyperthyroidism. Subclinical hypothyroidism, on the other hand, is not associated with osteoporosis or fragility fractures and subclinical hyperthyroidism treatment with radioiodine could improve bone health.

Funding

This research was partially supported by funding: PN-III-P1-1.2-PCCDI2017-0737: Genomic population mapping of radioactively and heavy metals contaminated areas in order to increase national-ARTEMIS.

Conflicts of Interest

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

References

  1. Sozen, T.; Ozisik, L.; Basaran, N.C. An overview and management of osteoporosis. Eur. J. Rheumatol. 2017, 4, 46–56. [Google Scholar] [CrossRef] [PubMed]
  2. Gennari, L.; Rotatori, S.; Bianciardi, S.; Nuti, R.; Merlotti, D. Treatment needs and current options for postmenopausal osteoporosis. Expert Opin. Pharm. 2016, 17, 1141–1152. [Google Scholar] [CrossRef] [PubMed]
  3. Jeremiah, M.P.; Unwin, B.K.; Greenawald, M.H.; Casiano, V.E. Diagnosis and management of osteoporosis. Am. Fam. Physician 2015, 92, 261–268. [Google Scholar] [PubMed]
  4. Piciu, D.; Irimie, A.; Kontogeorgos, G.; Piciu, A.; Buiga, R. Highly aggressive pathology of non-functional parathyroid carcinoma. Orphanet J. Rare Dis. 2013, 8, 115. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  5. Mester, A.; Apostu, D.; Ciobanu, L.; Piciu, A.; Lucaciu, O.; Campian, R.S.; Taulescu, M.; Bran, S. The impact of proton pump inhibitors on bone regeneration and implant osseointegration. Drug Metab. Rev. 2019, 51, 330–339. [Google Scholar] [CrossRef]
  6. Unnanuntana, A.; Gladnick, B.P.; Donnelly, E.; Lane, J.M. The assessment of fracture risk. J. Bone Jt. Surg. Ser. Am. Vol. 2010, 92, 743–753. [Google Scholar] [CrossRef] [Green Version]
  7. Williams, G.R. Thyroid hormone actions in cartilage and bone. Eur. Thyroid J. 2013, 2, 3–13. [Google Scholar] [CrossRef] [Green Version]
  8. Siddiqui, J.A.; Partridge, N.C. Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement. Physioloy 2016, 31, 233–245. [Google Scholar] [CrossRef]
  9. Bassett, J.H.D.; Williams, G.R. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. Endocr. Rev. 2016, 37, 135–187. [Google Scholar] [CrossRef] [Green Version]
  10. Baliram, R.; Latif, R.; Zaidi, M.; Davies, T.F. Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology. Front. Endocrinol. 2017, 8, 252. [Google Scholar] [CrossRef] [Green Version]
  11. Reddy, P.A.; Harinarayan, C.V.; Sachan, A.; Suresh, V.; Rajagopal, G. Bone disease in thyrotoxicosis. Indian J. Med. Res. 2012, 135, 277–286. [Google Scholar] [PubMed]
  12. Downey, C.; Kelly, M.; Quinlan, J.F. Changing trends in the mortality rate at 1-year post hip fracture—A systematic review. World J. Orthop. 2019, 10, 166–175. [Google Scholar] [CrossRef] [PubMed]
  13. Tsevis, K.; Trakakis, E.; Pergialiotis, V.; Alhazidou, E.; Peppa, M.; Chrelias, C.; Papantoniou, N.; Panagopoulos, P. The influence of thyroid disorders on bone density and biochemical markers of bone metabolism. Horm. Mol. Biol. Clin. Investig. 2018, 35, 1–7. [Google Scholar] [CrossRef] [PubMed]
  14. Ding, B.; Zhang, Y.; Li, Q.; Hu, Y.; Tao, X.-J.; Liu, B.-L.; Ma, J.-H.; Li, D.-M. Low Thyroid Stimulating Hormone Levels Are Associated with Low Bone Mineral Density in Femoral Neck in Elderly Women. Arch. Med. Res. 2016, 47, 310–314. [Google Scholar] [CrossRef]
  15. Tuchendler, D.; Bolanowski, M. Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism. Endokrynol. Pol. 2013, 64, 40–44. [Google Scholar]
  16. Svare, A.; Nilsen, T.I.L.; Bjoro, T.; Forsmo, S.; Schei, B.; Langhammer, A. Hyperthyroid levels of TSH correlate with low bone mineral density: The HUNT 2 study. Eur. J. Endocrinol. 2009, 161, 779–786. [Google Scholar] [CrossRef] [Green Version]
  17. Kim, D.J.; Khang, Y.H.; Koh, J.-M.; Shong, Y.K.; Kim, G.S. Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women. Clin. Endocrinol. 2006, 64, 86–90. [Google Scholar] [CrossRef]
  18. Babu, R.P.; Christy, A.; Hegde, A.; Manjrekar, P.; D’Souza, V. Do premenopausal hypothyroid women on levothyroxine therapy need bone status monitoring? Clin. Med. Insights Women’s 2015, 8, CMWH-S22114. [Google Scholar] [CrossRef]
  19. Ko, Y.-J.; Kim, J.Y.; Lee, J.; Song, H.-J.; Kim, J.-Y.; Choi, N.-K.; Park, B.-J. Levothyroxine dose and fracture risk according to the osteoporosis status in elderly women. J. Prev. Med. Public Health 2014, 47, 36–46. [Google Scholar] [CrossRef]
  20. Karimifar, M.; Esmaili, F.; Salari, A.; Kachuei, A.; Faragzadegan, Z.; Karimifar, M. Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism. J. Res. Pharm. Pr. 2014, 3, 83–87. [Google Scholar] [CrossRef]
  21. Konca Degertekin, C.; Turhan Iyidir, O.; Aktas Yılmaz, B.; Elbeg, S.; Pasaoglu, O.T.; Pasaoglu, H.; Cakır, N.; Arslan, M. RANKL/Osteoprotegerin System and Bone Turnover in Hashimoto Thyroiditis. Calcif. Tissue Int. 2016, 99, 365–372. [Google Scholar] [CrossRef] [PubMed]
  22. Lee, K.; Lim, S.; Park, H.; Woo, H.Y.; Chang, Y.; Sung, E.; Jung, H.S.; Yun, K.E.; Kim, C.W.; Ryu, S.; et al. Subclinical thyroid dysfunction, bone mineral density, and osteoporosis in a middle-aged Korean population. Osteoporos. Int. 2019. [Google Scholar] [CrossRef] [PubMed]
  23. Siru, R.; Alfonso, H.; Chubb, S.A.P.; Golledge, J.; Flicker, L.; Yeap, B.B. Subclinical thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men. Clin. Endocrinol. 2018, 89, 93–99. [Google Scholar] [CrossRef]
  24. Marwaha, R.K.; Garg, M.K.; Tandon, N.; Kanwar, R.; Narang, A.; Sastry, A.; Bhadra, K. Thyroid function and bone mineral density among Indian subjects. Indian J. Endocrinol. Metab. 2012, 16, 575–579. [Google Scholar] [CrossRef] [PubMed]
  25. Lee, W.Y.; Oh, K.W.; Rhee, E.J.; Jung, C.H.; Kim, S.W.; Yun, E.J.; Tae, H.J.; Baek, K.H.; Kang, M.I.; Choi, M.G.; et al. Relationship between subclinical thyroid dysfunction and femoral neck bone mineral density in women. Arch. Med. Res. 2006, 37, 511–516. [Google Scholar] [CrossRef] [PubMed]
  26. Bertoli, A.; Fusco, A.; Andreoli, A.; Magnani, A.; Tulli, A.; Lauro, D.; De Lorenzo, A. Effect of subclinical hypothyroidism and obesity on whole-body and regional bone mineral content. Horm. Res. 2002, 57, 79–84. [Google Scholar] [CrossRef] [PubMed]
  27. Gonzalez Rodriguez, E.; Stuber, M.; Del Giovane, C.; Feller, M.; Collet, T.-H.; Lowe, A.L.; Blum, M.R.; van Vliet, N.A.; van Heemst, D.; Kearney, P.M.; et al. Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. J. Clin. Endocrinol. Metab. 2020, 105, 6–26. [Google Scholar] [CrossRef]
  28. Pedrera-Zamorano, J.D.; Roncero-Martin, R.; Calderon-Garcia, J.F.; Santos-Vivas, M.; Vera, V.; Martinez-Alvarez, M.; Rey-Sanchez, P. Treatment of subclinical hypothyroidism does not affect bone mass as determined by dual-energy X-ray absorptiometry, peripheral quantitative computed tomography and quantitative bone ultrasound in Spanish women. Arch. Med. Sci. 2015, 11, 1008–1014. [Google Scholar]
  29. Tarraga Lopez, P.J.; Lopez, C.F.; de Mora, F.N.; Montes, J.A.R.; Albero, J.S.; Manez, A.N.; Casas, A.G. Osteoporosis in patients with subclinical hypothyroidism treated with thyroid hormone. Clin. Cases Min. Bone Metab. 2011, 8, 44–48. [Google Scholar]
  30. Meier, C.; Beat, M.; Guglielmetti, M.; Christ-Crain, M.; Staub, J.-J.; Kraenzlin, M. Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: A randomized controlled trial. Osteoporos. Int. 2004, 15, 209–216. [Google Scholar] [CrossRef] [Green Version]
  31. Rosario, P.W. Radioiodine therapy in elderly patients with subclinical hyperthyroidism due to non-voluminous nodular goiter and its effect on bone metabolism. Arq. Bras. Endocrinol. Metab. 2013, 57, 144–147. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  32. Thayakaran, R.; Adderley, N.J.; Sainsbury, C.; Torlinska, B.; Boelaert, K.; Sumilo, D.; Price, M.; Thomas, G.N.; Toulis, K.A.; Nirantharakumar, K. Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: Longitudinal study. BMJ 2019, 366, l4892. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  33. Rapacki, E.; Lauritzen, J.B.; Madsen, C.M.; Jorgensen, H.L.; Norring-Agerskov, D. Thyroid-stimulating hormone (TSH) is associated with 30-day mortality in hip fracture patients. Eur. J. Trauma Emerg. Surg. 2019, 1–7. [Google Scholar] [CrossRef]
  34. Maccagnano, G.; Notarnicola, A.; Pesce, V.; Mudoni, S.; Tafuri, S.; Moretti, B. The Prevalence of Fragility Fractures in a Population of a Region of Southern Italy Affected by Thyroid Disorders. BioMed Res. Int. 2016, 2016, 6017165. [Google Scholar] [CrossRef] [Green Version]
  35. Vestergaard, P.; Mosekilde, L. Fractures in patients with hyperthyroidism and hypothyroidism: A nationwide follow-up study in 16,249 patients. Thyroid 2002, 12, 411–419. [Google Scholar] [CrossRef] [PubMed]
  36. Abrahamsen, B.; Jorgensen, H.L.; Laulund, A.S.; Nybo, M.; Bauer, D.C.; Brix, T.H.; Hegedus, L. The excess risk of major osteoporotic fractures in hypothyroidism is driven by cumulative hyperthyroid as opposed to hypothyroid time: An observational register-based time-resolved cohort analysis. J. Bone Min. Res. 2015, 30, 898–905. [Google Scholar] [CrossRef]
  37. Polovina, S.P.; Miljic, D.; Zivojinovic, S.; Milic, N.; Micic, D.; Brkic, V.P. The impact of thyroid autoimmunity (TPOAb) on bone density and fracture risk in postmenopausal women. Hormones 2017, 16, 54–61. [Google Scholar]
  38. Lambrinoudaki, I.; Armeni, E.; Pliatsika, P.; Rizos, D.; Kaparos, G.; Augoulea, A.; Alexandrou, A.; Flokatoula, M.; Creatsa, M.; Panoulis, C.; et al. Thyroid function and autoimmunity are associated with the risk of vertebral fractures in postmenopausal women. J. Bone Miner. Metab. 2017, 35, 227–233. [Google Scholar] [CrossRef]
  39. Kim, K.-C.; Lee, Y.-K.; Lee, Y.J.; Ha, Y.-C.; Koo, K.-H. Bone health and clinical results after hip fracture surgery in patients with subclinical hypothyroidism. J. Bone Metab. 2014, 21, 213–216. [Google Scholar] [CrossRef] [Green Version]
  40. Garin, M.C.; Arnold, A.M.; Lee, J.S.; Robbins, J.; Cappola, A.R. Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: The cardiovascular health study. J. Clin. Endocrinol. Metab. 2014, 99, 2657–2664. [Google Scholar] [CrossRef]
  41. Polovina, S.; Popovic, V.; Duntas, L.; Milic, N.; Micic, D. Frax score calculations in postmenopausal women with subclinical hypothyroidism. Hormones 2013, 12, 439–448. [Google Scholar] [CrossRef] [PubMed]
  42. Lee, J.S.; Buzkova, P.; Fink, H.A.; Vu, J.; Carbone, L.; Chen, Z.; Cauley, J.; Bauer, D.C.; Cappola, A.R.; Robbins, J. Subclinical thyroid dysfunction and incident hip fracture in older adults. Arch. Intern. Med. 2010, 170, 1876–1883. [Google Scholar] [CrossRef] [PubMed]
  43. Zhu, H.; Zhang, J.; Wang, J.; Zhao, X.; Gu, M. Association of subclinical thyroid dysfunction with bone mineral density and fracture: A meta-analysis of prospective cohort studies. Endocrine 2019, 67, 685–698. [Google Scholar] [CrossRef] [PubMed]
  44. Yan, Z.; Huang, H.; Li, J.; Wang, J. Relationship between subclinical thyroid dysfunction and the risk of fracture: A meta-analysis of prospective cohort studies. Osteoporos. Int. 2016, 27, 115–125. [Google Scholar] [CrossRef]
  45. Blum, M.R.; Bauer, D.C.; Collet, T.-H.; Fink, H.A.; Cappola, A.R.; da Costa, B.R.; Wirth, C.D.; Peeters, R.P.; Asvold, B.O.; den Elzen, W.P.J.; et al. Subclinical thyroid dysfunction and fracture risk: A meta-analysis. JAMA 2015, 313, 2055–2065. [Google Scholar] [CrossRef] [Green Version]
  46. Segna, D.; Bauer, D.C.; Feller, M.; Schneider, C.; Fink, H.A.; Aubert, C.E.; Collet, T.-H.; da Costa, B.R.; Fischer, K.; Peeters, R.P.; et al. Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J. Intern. Med. 2018, 283, 56–72. [Google Scholar] [CrossRef] [Green Version]
  47. Chaker, L.; Bianco, A.C.; Jonklaas, J.; Peeters, R.P. Hypothyroidism. Lancet Lond. Engl. 2017, 390, 1550–1562. [Google Scholar] [CrossRef]
  48. Redford, C.; Vaidya, B. Subclinical hypothyroidism: Should we treat? Post Reprod. Heal. 2017, 23, 55–62. [Google Scholar] [CrossRef]
  49. Donangelo, I.; Suh, S.Y. Subclinical Hyperthyroidism: When to Consider Treatment. Am. Fam. Physician 2017, 95, 710–716. [Google Scholar]
  50. Piciu, D.; Irimie, A. Diagnosis and treatment guidelines in thyroid carcinoma. European and American consensus adapted to Romania. Acta Endocrinol. Buchar. 2007, 3, 103–115. [Google Scholar] [CrossRef]
  51. Piciu, D.; Irimie, A.; Piciu, A. Investigation of thyroid carcinoma over 40 years, using the database of the Ion Chiricuta Institute of Oncology Cluj-Napoca. J. BUON 2014, 19, 524–529. [Google Scholar] [PubMed]
Diagnostics 10 00149 g001 550
Figure 1. Physiopathology of the hypothalamic–pituitary–thyroid axis on bone metabolism. OPG = osteoprotegenrin; RANKL = receptor activator of nuclear factor kappa-B ligand; TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone; TSHR = thyroid-stimulating hormone receptor.
Figure 1. Physiopathology of the hypothalamic–pituitary–thyroid axis on bone metabolism. OPG = osteoprotegenrin; RANKL = receptor activator of nuclear factor kappa-B ligand; TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone; TSHR = thyroid-stimulating hormone receptor.
Diagnostics 10 00149 g001
Table
Table 1. Studies regarding the impact of hypothyroidism, autoimmune thyroid pathology, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on bone mineral density. BMD = bone mineral density; OPG = osteoprotegenrin; RANKL = receptor activator of nuclear factor kappa-B ligand; TSH = thyroid-stimulating hormone.
Table 1. Studies regarding the impact of hypothyroidism, autoimmune thyroid pathology, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on bone mineral density. BMD = bone mineral density; OPG = osteoprotegenrin; RANKL = receptor activator of nuclear factor kappa-B ligand; TSH = thyroid-stimulating hormone.
Type of StudyNumber of PatientsConclusionYearReferences
Hypothyroidism
Prospective188Hypothyroidism is associated with lower BMD2018[13]
Cross-sectional1097Lower TSH is related to decreased BMD2016[14]
Prospective119Hypothyroidism does not affect bone density2013[15]
Cross-sectional6722Lower TSH was related to the lowest BMD in the forearm2009[16]
Cross-sectional959Lower TSH was related to lower BMD2006[17]
Hypothyroidism treatment
Prospective75Levothyroxine increases bone turnover, but it does not lead to frank osteoporosis2015[18]
Retrospective11,155Overtreatment of hypothyroidism is associated with an increased rate of osteoporosis2014[19]
Retrospective150Levothyroxine is associated with a lower BMD2014[20]
Autoimmune thyroid pathology
Prospective80Hashimoto disease can further activate the OPG/RANKL system leading to additional bone loss2016[21]
Subclinical hypothyroidism
Retrospective25,510Subclinical hypothyroidism does not affect BMD2019[22]
Prospective4248Subclinical hypothyroidism is not predictive of incident hip fracture2018[23]
Cross-sectional1290TSH does not affect BMD2012[24]
Prospective413Subclinical hypothyroidism is associated with lower BMD2006[25]
Prospective32Subclinical hypothyroidism was related to a reduced leg BMD2002[26]
Subclinical hypothyroidism treatment
Prospective196Levothyroxine does not affect bone health2020[27]
Prospective45Levothyroxine treatment does not affect bone mass.2015[28]
Retrospective182Levothyroxine is associated with a higher bone loss2011[29]
Cross-sectional retrospective66Levothyroxine treatment is related to accelerated bone loss2004[30]
Subclinical hyperthyroidism
Prospective413Subclinical hyperthyroidism is associated with lower BMD2006[25]
Subclinical hyperthyroidism treatment
Prospective36Radioiodine has beneficial effects on BMD2013[31]
Table
Table 2. Studies regarding the impact of hypothyroidism, autoimmune thyroid pathology, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on fracture risk. TPOAb = thyroid autoantibodies.
Table 2. Studies regarding the impact of hypothyroidism, autoimmune thyroid pathology, subclinical hypothyroidism, subclinical hyperthyroidism, and their treatments on fracture risk. TPOAb = thyroid autoantibodies.
Type of StudyNumber of PatientsConclusionYearReferences
Hypothyroidism
Retrospective162,369TSH above the upper reference value increases the risk of fractures2019[32]
Retrospective914TSH above the median increases the early mortality rate in the case of surgically treated hip fractures2019[33]
Retrospective108,977Hypothyroidism is associated with increased risk of fracture2016[34]
Retrospective16,249Hypothyroidism is associated with increased fracture risk2002[35]
Hypothyroidism treatment
Retrospective230,552Overtreatment of hypothyroidism has a similar fracture risk, as seen in hyperthyroidism2015[36]
Autoimmune thyroid pathology
Prospective189TPOAb can be considered a marker for increased risk of fracture in euthyroid post-menopausal women2017[37]
Retroscpective335TPOAb can be considered a marker for increased risk of fracture2017[38]
Subclinical hypothyroidism
Prospective4248Subclinical hypothyroidism is not predictive of incident hip fracture2018[23]
Retrospective471Subclinical hypothyroidism is not associated with lower BMD2014[39]
Cross-sectional4963Subclinical hypothyroidism is not associated with increased hip fracture rate2014[40]
Prospective82Subclinical hypothyroidism has an increased fracture risk2013[41]
Prospective3567Subclinical hypothyroidism has an increased risk of hip fracture2010[42]
Subclinical hyperthyroidism
Prospective4248Subclinical hyperthyroidism is not predictive of incident hip fracture2018[23]
Cross-sectional4963Subclinical hyperthyroidism is not associated with increased hip fracture rate2014[40]
Prospective3567Subclinical hyperthyroidism has an increased risk of hip fracture2010[42]
Table
Table 3. Meta-analyses regarding the impact of subclinical hypothyroidism and subclinical hyperthyroidism on bone health.
Table 3. Meta-analyses regarding the impact of subclinical hypothyroidism and subclinical hyperthyroidism on bone health.
Bone-Related OutcomeNumber of PatientsConclusionYearReferences
Subclinical hypothyroidism
Osteoporosis
Fracture risk		313,557Subclinical hypothyroidism has no impact on fracture risk.2019[43]
Fracture risk314,146Subclinical hypothyroidism is not associated with an increased risk of fracture.2016[44]
Fracture risk70,298Subclinical hypothyroidism is not associated with an increased risk of fractures.2015[45]
Subclinical hyperthyroidism
Osteoporosis
Fracture risk		313,557Subclinical hyperthyroidism could increase the risk of fractures and decrease BMD.2019[40]
Osteoporosis5458Subclinical hyperthyroidism is associated with lower BMD.2018[46]
Fracture risk314,146Subclinical hyperthyroidism is associated with an increased risk of fracture.2016[44]
Fracture risk70,298Subclinical hyperthyroidism is associated with an increased risk of fractures.2015[45]

Share and Cite

MDPI and ACS Style

Apostu, D.; Lucaciu, O.; Oltean-Dan, D.; Mureșan, A.-D.; Moisescu-Pop, C.; Maxim, A.; Benea, H. The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review. Diagnostics 2020, 10, 149. https://doi.org/10.3390/diagnostics10030149

AMA Style

Apostu D, Lucaciu O, Oltean-Dan D, Mureșan A-D, Moisescu-Pop C, Maxim A, Benea H. The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review. Diagnostics. 2020; 10(3):149. https://doi.org/10.3390/diagnostics10030149

Chicago/Turabian Style

Apostu, Dragos, Ondine Lucaciu, Daniel Oltean-Dan, Alexandru-Dorin Mureșan, Cristina Moisescu-Pop, Andrei Maxim, and Horea Benea. 2020. "The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review" Diagnostics 10, no. 3: 149. https://doi.org/10.3390/diagnostics10030149

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop