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Diagnostics, Volume 10, Issue 1

January 2020 - 54 articles

Cover Story: Bladder cancer (BC) is rising in its incidence and prevalence and is accompanied by a high morbidity and mortality. Diagnosis and monitoring of BC is mainly performed through invasive tests (cystoscopies), which are highly uncomfortable for the patient and not exempt of comorbidities. There is an imperative need for non-invasive testing for early detection, disease monitoring, and treatment response in BC. In this review, we compare different tests based on molecular biomarkers and evaluate their potential role in BC diagnosis, follow-up, and treatment response monitoring. View this paper.
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Articles (54)

  • Article
  • Open Access
15 Citations
5,016 Views
15 Pages

Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder

  • Yoshitaka Itami,
  • Makito Miyake,
  • Sayuri Ohnishi,
  • Yoshihiro Tatsumi,
  • Daisuke Gotoh,
  • Shunta Hori,
  • Yousuke Morizawa,
  • Kota Iida,
  • Kenta Ohnishi and
  • Yasushi Nakai
  • + 9 authors

Disabled homolog-2 (DAB2) has been reported to be a tumor suppressor gene. However, a number of contrary studies suggested that DAB2 promotes tumor invasion in urothelial carcinoma of the bladder (UCB). Here, we investigated the clinical role and bio...

  • Article
  • Open Access
9 Citations
4,630 Views
10 Pages

Cardiac Catheterization versus Echocardiography for Monitoring Pulmonary Pressure: A Prospective Study in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

  • Vasiliki Kalliopi Bournia,
  • Iraklis Tsangaris,
  • Loukianos Rallidis,
  • Dimitrios Konstantonis,
  • Frantzeska Frantzeskaki,
  • Anastasia Anthi,
  • Stylianos E. Orfanos,
  • Eftychia Demerouti,
  • Panagiotis Karyofillis and
  • Vassilis Voudris
  • + 4 authors

Standard echocardiography is important for pulmonary arterial hypertension (PAH) screening in patients with connective tissue disease (CTD), but PAH diagnosis and monitoring require cardiac catheterization. Herein, using cardiac catheterization as re...

  • Article
  • Open Access
20 Citations
4,537 Views
13 Pages

Widefield Swept Source OCTA in Retinitis Pigmentosa

  • Rodolfo Mastropasqua,
  • Rossella D’Aloisio,
  • Chiara De Nicola,
  • Giada Ferro,
  • Alfonso Senatore,
  • Daniele Libertini,
  • Guido Di Marzio,
  • Marta Di Nicola,
  • Giuseppe Di Martino and
  • Luca Di Antonio
  • + 1 author

(1) Background: To evaluate superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), perfusion density (PD), and vessel length density (VLD) in macular and near/mid periphery regions in patients with retinitis pigmentos...

  • Article
  • Open Access
19 Citations
8,925 Views
17 Pages

The Influence of Serum Sample Storage Conditions on Selected Laboratory Parameters Related to Oxidative Stress: A Preliminary Study

  • Lilla Pawlik-Sobecka,
  • Katarzyna Sołkiewicz,
  • Izabela Kokot,
  • Aleksandra Kiraga,
  • Sylwia Płaczkowska,
  • Agnieszka Matylda Schlichtinger and
  • Ewa Maria Kratz

The present work aims at accessing the stability of biological material stored for diagnostic and scientific purposes. The influence of the temperature, storage time, and cyclic thawing on concentration stability of selected oxidative stress paramete...

  • Review
  • Open Access
99 Citations
16,439 Views
16 Pages

Mucinous ovarian cancer (MOC) is a rare subtype of epithelial ovarian carcinoma (EOC). Whereas all EOC subtypes are addressed in the same way, MOC is a distinct entity. Appreciating the pathological features and genomic profile of MOC may result in t...

  • Article
  • Open Access
7 Citations
3,719 Views
11 Pages

High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto’s Thyroiditis: A Next-Generation Sequencing Analysis

  • Csaba Molnár,
  • Emese Sarolta Bádon,
  • Attila Mokánszki,
  • Anikó Mónus,
  • Lívia Beke,
  • Ferenc Győry,
  • Endre Nagy and
  • Gábor Méhes

The close association between pre-existing Hashimoto’s thyroiditis and thyroid cancer is well established. The simultaneous occurrence of multiple neoplastic foci within the same organ suggests a common genotoxic effect potentially contributing...

  • Article
  • Open Access
9 Citations
4,691 Views
12 Pages

Assessment of Activity of Daily Life in Mucopolysaccharidosis Type II Patients with Hematopoietic Stem Cell Transplantation

  • Yasuyuki Suzuki,
  • Madeleine Taylor,
  • Kenji Orii,
  • Toshiyuki Fukao,
  • Tadao Orii and
  • Shunji Tomatsu

The effectiveness of hematopoietic stem cell transplantation (HSCT) for mucopolysaccharidosis type II (MPS II, Hunter disease) remains controversial although recent studies have shown HSCT provides more clinical impact. This study aims to evaluate th...

  • Article
  • Open Access
10 Citations
4,908 Views
14 Pages

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

  • Alma D. Del Angel-Pablo,
  • Ana Itzel Juárez-Martín,
  • Gloria Pérez-Rubio,
  • Enrique Ambrocio-Ortiz,
  • Luis A. López-Flores,
  • Angel E. Camarena and
  • Ramcés Falfán-Valencia

Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from the mixture of three founder populations; Amerindian...

  • Case Report
  • Open Access
18 Citations
5,782 Views
9 Pages

Papillary Thyroid Cancer in a Struma Ovarii in a 17-Year-Old Nulliparous Patient: A Case Report

  • Agnieszka Gonet,
  • Rafał Ślusarczyk,
  • Danuta Gąsior-Perczak,
  • Artur Kowalik,
  • Janusz Kopczyński and
  • Aldona Kowalska

Introduction: Struma ovarii accounts for 2% of mature teratomas. Struma ovarii is diagnosed when thyroid tissue accounts for >50% of the teratoma. Malignant transformation is rare, occurring in <5% of struma ovarii cases. Case presentation: A 1...

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Diagnostics - ISSN 2075-4418