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Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

Division of Gynecologic Oncology, University of Kentucky, Lexington, KY 40502, USA
Division of Surgical Oncology, University of Kentucky, Lexington, KY 40502, USA
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(1), 43;
Received: 19 December 2019 / Revised: 9 January 2020 / Accepted: 10 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Ovarian Cancer: Characteristics, Screening, Diagnosis and Treatment)
Hyperthermic intraperitoneal chemotherapy (HIPEC) in conjunction with cytoreductive surgery (CRS) holds promise as an adjunctive treatment strategy in malignancies affecting the peritoneal surface, effectively targeting remaining microscopic residual tumor. HIPEC increases concentrations of chemotherapy directly within the peritoneal cavity compared with the intravenous route and reduces the systemic side effects associated with prolonged adjuvant intraperitoneal exposure. Furthermore, hyperthermia increases tissue penetration and is synergistic with the therapeutic chemotherapy agents used. In ovarian cancer, evidence is building for its use in both primary and recurrent scenarios. In this review, we examine the history of HIPEC, the techniques used, and the available data guiding its use in primary and recurrent ovarian cancer. View Full-Text
Keywords: HIPEC; ovarian cancer; peritoneal cancer; review; technique HIPEC; ovarian cancer; peritoneal cancer; review; technique
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MDPI and ACS Style

Riggs, M.J.; Pandalai, P.K.; Kim, J.; Dietrich, C.S. Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. Diagnostics 2020, 10, 43.

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