Special Issue "Imaging of Early Response in Cancer Management 2019"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Kalevi Kairemo

Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
E-Mail
Interests: PET: evaluation of early response, EBRT dose planning, tracer development in oncology, hypoxia; targeted drug delivery: imaging applications, PET/SPECT; Radionuclide therapy: personalized approaches, dosimetry

Special Issue Information

Dear Colleagues,

The editorial team of Diagnostics is setting up a new Special Issue on PET in early response evaluation in cancer management.

This Special Issue will cover advances in PET methodology, with special consideration of its application in the field of early response in chemotherapy and radiation therapy. Submissions will be invited covering the clinical role of PET tracers, such as FDG and FLT, in the follow-up of oncologic malignancies.

This publication will especially address early response in the therapy monitoring of new pharmaceuticals and biologicals. In addition, new radiopharmaceuticals will be discussed for their potential in this section of clinical oncology.

Prof. Dr. Kalevi Kairemo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET methodology
  • early response
  • cancer management
  • chemotherapy
  • radiation therapy
  • FDG
  • FLT

Published Papers (1 paper)

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Research

Open AccessArticle
Very Early Response Evaluation by PET/MR in Patients with Lung Cancer—Timing and Feasibility
Diagnostics 2019, 9(1), 35; https://doi.org/10.3390/diagnostics9010035
Received: 18 January 2019 / Revised: 17 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
PDF Full-text (840 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Purpose: With the increasing number of therapy options available for patients with lung cancer, early response evaluation is needed. We performed this pilot study to assess the feasibility of early, repeated Positron emission tomography-magnetic resonance (PET/MR), the impact of timing and the capability [...] Read more.
Purpose: With the increasing number of therapy options available for patients with lung cancer, early response evaluation is needed. We performed this pilot study to assess the feasibility of early, repeated Positron emission tomography-magnetic resonance (PET/MR), the impact of timing and the capability for response prediction in lung tumors during chemotherapy. Methods: Patients with stage IV non-small cell lung cancer referred for chemotherapy were prospectively recruited. Fluorine-18-Fluorodeoxyglucose(18F-FDG)-PET/MR scans were performed prior to, during and after the first or second cycle of chemotherapy. Primary tumors were defined on all scans and size, FDG-uptake and apparent diffusion coefficient (ADC) were measured. Early response was described over time and a Standard Linear Mixed Model was applied to analyze changes over time. Results: 45 FDG-PET/MR scans were performed in 11 patients. Whereas the overall changes measured by ADC did not change significantly, there was an overall significant decrease in FDG-uptake from pre to post treatment scans. There was no difference in the FDG-uptake measured 1 or 3 weeks after therapy, but uptake measured 2 weeks after therapy differed from measurements at week 3. Changes measured in patients scanned during the first treatment cycle appeared more pronounced than during the second cycle. Conclusions: This pilot study indicates that response evaluation shortly after initiation of chemotherapy appears concordant with later evaluation and probably more reliable than evaluation midway between cycles. Responses during or after the first cycle of chemotherapy rather than during subsequent cycles are likely to be more readily measured. Full article
(This article belongs to the Special Issue Imaging of Early Response in Cancer Management 2019)
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