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Life, Volume 15, Issue 10

2025 October - 149 articles

Cover Story: Research on inter-organ crosstalk in the body is growing rapidly, especially regarding bidirectional communication between the brain and other organs. This interaction is crucial as its dysregulation may contribute to brain diseases, including neurodegenerative disorders, thus offering potential biomarkers to define strategies for prevention, diagnosis, and treatment, as well as for personalised medicine protocols. Although the central nervous system was once thought of as isolated from peripheral influences, evidence shows a complex network of signalling molecules (cytokines, growth factors, metabolites, hormones) linking the brain to peripheral organs, able to affect both brain and peripheral functions. Key communication pathways in neurodegeneration involve the gut–brain, brain–adipose tissue, brain–liver, brain–immune system, and brain–muscle axes. View this paper
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Articles (149)

  • Article
  • Open Access
867 Views
15 Pages

20 October 2025

The aim of this retrospective clinical pilot study is to evaluate multiparametric ultrasound liver parenchyma assessments in the diagnosis of Osler’s disease, and to detect micro-shunts using SRCEUS with quantifications at the capillary level....

  • Article
  • Open Access
696 Views
19 Pages

Can Improved Biosecurity Measures Reduce the Presence of the Most Common ESBL-Producing Enterobacteriaceae? A Study from Greek Pig Farms

  • Nikolaos Tsekouras,
  • Spyridon Antoniadis,
  • Zoi Athanasakopoulou,
  • Dimitris C. Chatzopoulos,
  • Dimitrios Kantas,
  • Vassiliki Spyrou,
  • Georgios Christodoulopoulos,
  • Charalambos Billinis and
  • Vasileios G. Papatsiros

19 October 2025

This study investigates the relationship between biosecurity implementation and the prevalence of ESBL-producing bacteria in Greek swine farms, revealing an alarming 82% prevalence rate, which is significantly higher than in other European nations. O...

  • Article
  • Open Access
1,586 Views
16 Pages

Implementation of a Generative AI-Powered Digital Interactive Platform for Clinical Language Therapy in Children with Language Delay: A Pilot Study

  • Chia-Hui Chueh,
  • Tzu-Hui Chiang,
  • Po-Wei Pan,
  • Ko-Long Lin,
  • Yen-Sen Lu,
  • Sheng-Hui Tuan,
  • Chao-Ruei Lin,
  • I-Ching Huang and
  • Hsu-Sheng Cheng

18 October 2025

Early intervention is pivotal for optimizing neurodevelopmental outcomes in children with language delay, where increased language stimulation can optimize therapeutic outcomes. Extending speech–language therapy from clinical settings to the ho...

  • Article
  • Open Access
1,027 Views
22 Pages

18 October 2025

A better understanding of diabetic kidney disease (DKD) will help optimize its management. Few animal models replicate human DKD characteristics as closely as ZSF1 male rats. To address the male-specific focus in murine model systems, we aimed to cha...

  • Article
  • Open Access
1 Citations
2,988 Views
20 Pages

Variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort of 98 Cases, Historical Comparison, and Updated Management Algorithm

  • Laurențiu Augustus Barbu,
  • Liliana Cercelaru,
  • Ionică-Daniel Vîlcea,
  • Valeriu Șurlin,
  • Stelian-Stefaniță Mogoantă,
  • Tiberiu Stefăniță Țenea Cojan,
  • Nicolae-Dragoș Mărgăritescu,
  • Ana-Maria Țenea Cojan,
  • Valentina Căluianu and
  • Liviu Vasile
  • + 2 authors

17 October 2025

Background: Variceal upper gastrointestinal bleeding (VUGIB) remains a major cause of short-term mortality in cirrhosis despite advances in endoscopic and pharmacological therapy. Prognostic factors and outcomes were evaluated in a historical cohort,...

  • Article
  • Open Access
1,132 Views
24 Pages

17 October 2025

The highly pathogenic avian influenza (HPAI) H5N1 virus poses a growing global health threat, particularly following its unprecedented spillover into dairy cattle and subsequent transmission to more than 1000 dairy farms in 18 states. This study inve...

  • Protocol
  • Open Access
1,715 Views
18 Pages

The Impact of Physical Therapy on Postural and Myotonometric Disorders in Patients with Pectus Excavatum: Study Protocol

  • Marius-Zoltan Rezumeș,
  • Liliana Cațan,
  • Elena Amăricăi,
  • Ada-Maria Codreanu,
  • Andreea-Ancuța Vătăman and
  • Vlad-Laurentiu David

17 October 2025

Pectus excavatum (PE) is the most common deformity of the chest wall seen in children and adolescents. Besides its visible depression of the chest, this condition often causes functional impairments affecting the cardiovascular and respiratory system...

  • Article
  • Open Access
963 Views
15 Pages

17 October 2025

Fencing demands a unique blend of endurance, explosive power, and asymmetric neuromuscular control. This study compared physiological profiles of elite (top 25 nationally ranked, n = 16) and non-elite (positions 26–102, n = 33) Polish male fenc...

  • Article
  • Open Access
2,619 Views
13 Pages

A Chronocosmetic Approach to Treating Signs of Aging with Glutathione

  • Candelaria Contreras-Agudelo,
  • Amin Ariza-Donado,
  • Mariana Villegas-Gallego,
  • Aura Villa-Sierra,
  • Jennifer Naranjo-Narvaez and
  • Isabella Martinez-Meza

17 October 2025

Cutaneous aging is associated with oxidative stress and visible changes on the skin, such as uneven pigmentation, wrinkles, and loss of radiance. Glutathione (GSH), an endogenous antioxidant with anti-melanogenic properties, is considered a promising...

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Life - ISSN 2075-1729