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Life, Volume 10, Issue 2

2020 February - 12 articles

Cover Story: Classical resistance classifications are very useful for epidemiological purposes, but they may not correlate well with clinical outcomes. Therefore, several novel classification criteria have recently been introduced for Gram-negative bacteria. Microbiological and resistance data were collected for urinary tract infections (UTIs) retrospectively, corresponding to the 01 January 2008–31 December 2017 period. The introduction of difficult-to-treat resistance (and its modifications detailed in this study) to the bedside and in clinical practice will definitely lead to substantial benefits in the assessment of the significance of bacterial resistance in human therapeutics. View this paper
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Articles (12)

  • Book Review
  • Open Access
3 Citations
4,706 Views
11 Pages

18 February 2020

David Deamer has written another book, Assembling Life, on the origin of life. It is unapologetically polemic, presenting Deamer’s view that life originated in fresh water hydrothermal fields on volcanic islands on early Earth, arguing that this prov...

  • Article
  • Open Access
4 Citations
4,364 Views
14 Pages

Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols

  • Adèle Dramé-Maigné,
  • Anton S. Zadorin,
  • Iaroslava Golovkova and
  • Yannick Rondelez

13 February 2020

High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps. In order to optimise these approaches, or compare one to another, one ne...

  • Article
  • Open Access
69 Citations
9,077 Views
17 Pages

11 February 2020

Classical resistance classifications (multidrug resistance [MDR], extensive drug resistance [XDR], pan-drug resistance [PDR]) are very useful for epidemiological purposes, however, they may not correlate well with clinical outcomes, therefore, severa...

  • Article
  • Open Access
8 Citations
4,918 Views
20 Pages

Coupling of Cell Division and Differentiation in Arabidopsis thaliana Cultured Cells with Interaction of Ethylene and ABA Signaling Pathways

  • Galina V. Novikova,
  • Natalia S. Stepanchenko,
  • Anna A. Zorina,
  • Alexander V. Nosov,
  • Victor Y. Rakitin,
  • Igor E. Moshkov and
  • Dmitry A. Los

10 February 2020

Recent studies indicate direct links between molecular cell cycle and cell differentiation machineries. Ethylene and abscisic acid (ABA) are known to affect cell division and differentiation, but the mechanisms of such effects are poorly understood....

  • Article
  • Open Access
37 Citations
17,127 Views
27 Pages

Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome

  • Nuria Conde-Pueyo,
  • Blai Vidiella,
  • Josep Sardanyés,
  • Miguel Berdugo,
  • Fernando T. Maestre,
  • Victor de Lorenzo and
  • Ricard Solé

9 February 2020

What is the potential for synthetic biology as a way of engineering, on a large scale, complex ecosystems? Can it be used to change endangered ecological communities and rescue them to prevent their collapse? What are the best strategies for such eco...

  • Article
  • Open Access
21 Citations
6,135 Views
12 Pages

Endolithic Fungal Species Markers for Harshest Conditions in the McMurdo Dry Valleys, Antarctica

  • Claudia Coleine,
  • Nuttapon Pombubpa,
  • Laura Zucconi,
  • Silvano Onofri,
  • Jason E. Stajich and
  • Laura Selbmann

6 February 2020

The microbial communities that inhabit lithic niches inside sandstone in the Antarctic McMurdo Dry Valleys of life’s limits on Earth. The cryptoendolithic communities survive in these ice-free areas that have the lowest temperatures on Earth co...

  • Article
  • Open Access
8 Citations
5,947 Views
15 Pages

2 February 2020

Implicit in the RNA world hypothesis is that prebiotic RNA synthesis, despite occurring in an environment without biochemical catalysts, produced the long RNA polymers which are essential to the formation of life. In order to investigate the prebioti...

  • Article
  • Open Access
4 Citations
3,933 Views
12 Pages

RNA Aptamers for a tRNA-Binding Protein from Aeropyrum pernix with Homologous Counterparts Distributed Throughout Evolution

  • Senri Ohmori,
  • Marina Wani,
  • Saki Kitabatake,
  • Yuka Nakatsugawa,
  • Tadashi Ando,
  • Takuya Umehara and
  • Koji Tamura

1 February 2020

In the present in vitro selection study, we isolated and characterized RNA aptamers for a tRNA-binding protein (Trbp) from an extremophile archaeon Aeropyrum pernix. Trbp-like structures are frequently found not only in aminoacyl-tRNA synthetases but...

  • Article
  • Open Access
1 Citations
5,226 Views
7 Pages

Indexing Exoplanets with Physical Conditions Potentially Suitable for Rock-Dependent Extremophiles

  • Madhu Kashyap Jagadeesh,
  • Sagarika Rao Valluri,
  • Vani Kari,
  • Katarzyna Kubska and
  • Łukasz Kaczmarek

26 January 2020

The search for different life forms elsewhere in the universe is a fascinating area of research in astrophysics and astrobiology. Currently, according to the NASA Exoplanet Archive database, 3876 exoplanets have been discovered. The Earth Similarity...

  • Article
  • Open Access
12 Citations
10,120 Views
21 Pages

A Theoretical Approach for the Electrochemical Characterization of Ciliary Epithelium

  • Riccardo Sacco,
  • Giovanna Guidoboni,
  • Joseph W. Jerome,
  • Giulio Bonifazi,
  • Nicholas M. Marazzi,
  • Alice C. Verticchio Vercellin,
  • Matthew S. Lang and
  • Alon Harris

23 January 2020

The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for drug therapy in glaucoma, and t...

  • Article
  • Open Access
12 Citations
5,342 Views
15 Pages

23 January 2020

Protein sequence space is vast; nature uses only an infinitesimal fraction of possible sequences to sustain life. Are there solutions to biological problems other than those provided by nature? Can we create artificial proteins that sustain life? To...

  • Concept Paper
  • Open Access
19 Citations
9,256 Views
41 Pages

21 January 2020

The current framework of evolutionary theory postulates that evolution relies on random mutations generating a diversity of phenotypes on which natural selection acts. This framework was established using a top-down approach as it originated from Dar...

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Life - ISSN 2075-1729