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Antibodies, Volume 12, Issue 4

December 2023 - 23 articles

Cover Story: Lyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. The disease is characterized by a varied course; therefore, the basis for diagnosis is laboratory methods. Currently, a two-tiered serological test is recommended, using an ELISA as a screening test and a Western blot as a confirmatory test. This approach was introduced due to the relatively high number of false-positive results obtained when using an ELISA alone. However, even this approach has not entirely solved the problem of false-positive results caused by cross-reactive antibodies. Many highly immunogenic B. burgdorferi s.l. proteins are recognized nonspecifically by antibodies directed against other pathogens. View this paper

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Review

19 Citations

11,932 Views

20 Pages

Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease

Weronika Grąźlewska and
Lucyna Holec-Gąsior

Antibodies2023, 12(4), 63;https://doi.org/10.3390/antib12040063

5 October 2023

Lyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. The disease is characterized by a varied course; therefore, the basis for diagnosis is laboratory methods. Currently, a two-tiered se...

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Article

3,318 Views

12 Pages

Subtractive Immunization as a Method to Develop Respiratory Syncytial Virus (RSV)—Specific Monoclonal Antibodies

Lotte Jacobs,
Kim Stobbelaar,
Annick Heykers,
Paul Cos and
Peter Delputte

Antibodies2023, 12(4), 62;https://doi.org/10.3390/antib12040062

26 September 2023

Respiratory Syncytial Virus (RSV) is a significant cause of lower respiratory tract infections in the young, the elderly, and in immunodeficient patients. As such, the virus represents an important cause of morbidity and mortality worldwide. Developm...

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Article

4 Citations

3,322 Views

13 Pages

Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals

Tatjana Vilibic-Cavlek,
Vladimir Stevanovic,
Snjezana Kovac,
Ema Borko,
Maja Bogdanic,
Gorana Miletic,
Zeljka Hruskar,
Thomas Ferenc,
Ivona Coric and
Mateja Vujica Ferenc
+ 3 authors

Antibodies2023, 12(4), 61;https://doi.org/10.3390/antib12040061

25 September 2023

Background: Serological diagnosis of COVID-19 is complex due to the emergence of different SARS-CoV-2 variants. Methods: 164 serum samples from (I) patients who recovered from COVID-19 (n = 62) as well as (II) vaccinated individuals (n = 52) and (III...

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