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Antibodies, Volume 15, Issue 3

2026 June - 13 articles

Cover Story: Monoclonal antibody (mAb) discovery has been transformed by advances in single-cell technologies, microfluidics, high-throughput sequencing, and computational design. Modern platforms enable the interrogation of large numbers of individual B cells, directly linking antibody sequence with antigen specificity and functional activity. Microfluidic and optofluidic systems now support high-throughput compartmentalisation and functional screening of antibody-secreting cells, while sequencing-based approaches allow parallel recovery of paired heavy- and light-chain sequences. These developments have shifted antibody discovery from binding-based selection toward function-first paradigms, enabling the rapid identification of diagnostic and therapeutically relevant antibodies. View this paper
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Articles (13)

  • Article
  • Open Access
683 Views
12 Pages

Characterization of Anti-Phospholipid Antibodies in Lyme Borreliosis Using In-House Developed ELISAs

  • Polona Žigon,
  • Katja Lakota,
  • Katarina Ogrinc,
  • Petra Bogovič and
  • Franc Strle

Objectives: Borrelia burgdorferi sensu lato, a spirochete bacterium responsible for Lyme borreliosis—the most common tick-borne infection in North America and Europe—can trigger the production of antiphospholipid antibodies. These antibod...

(This article belongs to the Section Antibody-Based Diagnostics)
  • Review
  • Open Access
1,283 Views
25 Pages

Anti-Type I Interferon Autoantibodies in COVID-19 and Systemic Lupus Erythematosus: A Comparative Review

  • Xin Rong Lim,
  • Ryan Xuan Wei Teo,
  • Rae Yi Xin Par and
  • Bernard Pui Lam Leung

Type I interferons (IFN-I), including IFN-α, IFN-β, and IFN-ω, are central to antiviral defence and immune regulation. Autoantibodies targeting IFN-I (anti-IFN-I AAbs) have emerged as key pathogenic factors in severe coronavirus dise...

(This article belongs to the Section Antibody-Based Diagnostics)
  • Review
  • Open Access
1,230 Views
23 Pages

Improving Gallbladder Cancer Outcomes with Antibody-Based Therapies and Immunological Profiling: A Literature Review

  • Christian Caglevic,
  • Mario Alex Contreras-Torrez,
  • Felipe Reyes-Cosmelli,
  • Rodrigo Uribe-Maturana,
  • Mauricio Mahave,
  • Nicole Caire,
  • Luis Villanueva-Olivares,
  • Fernando Cid,
  • Alvaro Lladser and
  • Jorge Sapunar

Gallbladder cancer (GBC) is an aggressive tumor that, together with the cholangiocarcinomas, constitutes the spectrum of biliary tract cancer (BTC). These tumors are characterized by a frequently late diagnosis, marked genomic heterogeneity, variable...

(This article belongs to the Topic Antibody-Mediated Therapy and Other Emerging Therapies in Cancer Treatment)
  • Review
  • Open Access
1,035 Views
12 Pages

Background: Monoclonal antibodies (mAbs) initially played a major role in outpatient COVID-19 management by providing rapid passive immunity and reducing progression to severe disease. However, continuous SARS-CoV-2 evolution progressively compromise...

(This article belongs to the Section Antibody-Based Therapeutics)
  • Review
  • Open Access
1,567 Views
23 Pages

From Single Cells to Silicon: Emerging Technologies Transforming Monoclonal Antibody Discovery

  • Victoria Sherwood,
  • Denise Harold,
  • Richard O’Kennedy,
  • Christine Loscher and
  • Paul Leonard

Monoclonal antibody (mAb) discovery has been transformed by advances in single-cell technologies, microfluidics, high-throughput sequencing, and computational design. Modern platforms enable the interrogation of large numbers of individual B cells, d...

(This article belongs to the Topic Antibody-Mediated Therapy and Other Emerging Therapies in Cancer Treatment)
  • Article
  • Open Access
962 Views
14 Pages

Background/Objectives: Ocrelizumab is a humanized monoclonal antibody targeting CD20, approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). The neutralizing activity of...

(This article belongs to the Section Antibody-Based Therapeutics)
  • Article
  • Open Access
1,132 Views
14 Pages

A Novel Monoclonal Antibody Targeting the A29 Protein of Monkeypox Virus and Its Application in Immunoassay

  • Nan Jia,
  • Weixiao Wang,
  • Guangwei Zhao,
  • Danfei Meng,
  • Liyuan Zheng and
  • Jinhua Dong

Background: The monkeypox virus (MPXV) has attracted considerable global attention due to its potential to cause widespread outbreaks, necessitating the development of rapid and accurate diagnostic methods of significant clinical importance. A29, a k...

(This article belongs to the Section Antibody Discovery and Engineering)
  • Review
  • Open Access
1,477 Views
23 Pages

Background/Objectives: Chronic spontaneous urticaria (CSU) is characterized by almost daily wheals or angioedema lasting for more than six weeks and not attributable to a defined inducing factor. CSU reportedly affects 1–2% of the general popul...

(This article belongs to the Section Antibody-Based Diagnostics)
  • Article
  • Open Access
842 Views
13 Pages

Computational Study of Antibody Binding to SARS-CoV-2 Variants

  • Carolyn Chiu,
  • Muhammad Zaki Jawaid and
  • Daniel Lee Cox

Background/Objectives: The unprecedented structural and binding data for antibodies to the SARS-CoV-2 virus taken together with the mutations for the spike protein allows for a broad simulation study of antibody–spike protein binding. This prov...

(This article belongs to the Section Antibody-Based Therapeutics)
  • Article
  • Open Access
1,445 Views
18 Pages

Immune-Related Adverse Events of Cemiplimab Therapy in Advanced Cervical Cancer—Data from the Polish–Czech Cervical Cancer Immunotherapy Group (PCCIG-01) with a Review of the Literature

  • Radosław Łupkowski,
  • Karolina Górniak,
  • Maja Lisik-Habib,
  • Ewa Burchardt,
  • Radosław Mądry,
  • Monika Szarszewska,
  • Katarzyna Gabalewicz,
  • Dominika Pyszak,
  • Petra Bretova and
  • Renata Pacholczak-Madej
  • + 10 authors

Background: Immunotherapy has become an integral part of systemic treatment for cervical cancer (CC). This study assessed the safety profile of cemiplimab and the association between immune-related adverse events (irAEs) and treatment outcomes in pat...

(This article belongs to the Section Antibody-Based Therapeutics)
  • Article
  • Open Access
881 Views
15 Pages

The Shifting Core: Antigenic Variability of the Influenza Virus Nucleoprotein Despite Evolutionary Conservation

  • Alexandra Rak,
  • Veronika Muzurova,
  • Svetlana Donina,
  • Polina Prokopenko,
  • Irina Isakova-Sivak and
  • Larisa Rudenko

Background. The highly mutable influenza virus causes severe annual infections worldwide and results in substantial socioeconomic losses. The spread of infection could be effectively controlled by cross-protective vaccines and universal diagnostic te...

(This article belongs to the Section Humoral Immunity)
  • Case Report
  • Open Access
1,222 Views
17 Pages

Safety and Efficacy of Mosunetuzumab: Experience in the Hospital Cardinale Giovanni Panico

  • Giulio Turco,
  • Donatella Tarantino,
  • Antonietta Giuseppa Ferraro,
  • Giuseppina Greco and
  • Domenico Tricarico

Background/Objective: Follicular lymphoma (FL) is one of the most common indolent B-cell non-Hodgkin lymphomas (NHL) and is characterized by recurrent relapses despite advances in therapy. Bispecific antibodies that redirect T lymphocytes toward mali...

(This article belongs to the Section Antibody-Based Therapeutics)
  • Article
  • Open Access
1 Citations
1,308 Views
15 Pages

Ca13Mab-17, a Novel Anti-Cadherin-13 Monoclonal Antibody for Versatile Applications

  • Kai Shimizu,
  • Hiroyuki Suzuki,
  • Mika K. Kaneko and
  • Yukinari Kato

Background/Objectives: Cadherin-13 (CDH13), part of the cadherin family, is attached to the plasma membrane through glycosylphosphatidylinositol. CDH13 plays essential roles in the development of the neurological and vascular systems and is a risk fa...

(This article belongs to the Section Antibody Discovery and Engineering)
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Antibodies - ISSN 2073-4468