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Cdx2 Animal Models Reveal Developmental Origins of Cancers

Laboratory of Cell Differentiation, Institute of Molecular Genetics of the Czech Academy of Sciences, v.v.i. Vídenská 1083, 4 14220 Prague, Czech Republic
Genes 2019, 10(11), 928; https://doi.org/10.3390/genes10110928
Received: 11 October 2019 / Revised: 6 November 2019 / Accepted: 13 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Animal Modeling in Cancer)
The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias—normal tissue arising in an abnormal location—and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett’s esophagus) and stomach. Conversely, loss of Cdx2 function can elicit an anterior shift in tissue identity, inducing serrated-type lesions expressing gastric markers in the colon. These metaplasias are major risk factors for the later development of esophageal, stomach and colon cancer. Leukemia, another cancer in which Cdx2 is ectopically expressed, may have mechanistic parallels with epithelial cancers in terms of stress-induced reprogramming. This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers. View Full-Text
Keywords: metaplasia; Cdx; cancer; animal models metaplasia; Cdx; cancer; animal models
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Chawengsaksophak, K. Cdx2 Animal Models Reveal Developmental Origins of Cancers. Genes 2019, 10, 928.

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