Next Article in Journal
Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases
Previous Article in Journal
HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data
Open AccessReview

Cell-Specific DNA Methylation Signatures in Asthma

1
Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, G7H 2B1 QC, Canada
2
Centre intersectoriel en santé durable (CISD), Université du Québec à Chicoutimi (UQAC), Saguenay, G7H 2B1 QC, Canada
3
Quebec Respiratory Health Network, Quebec, G1V 4G5 QC, Canada
*
Author to whom correspondence should be addressed.
Genes 2019, 10(11), 932; https://doi.org/10.3390/genes10110932
Received: 15 October 2019 / Revised: 8 November 2019 / Accepted: 12 November 2019 / Published: 15 November 2019
Asthma is a complex trait, often associated with atopy. The genetic contribution has been evidenced by familial occurrence. Genome-wide association studies allowed for associating numerous genes with asthma, as well as identifying new loci that have a minor contribution to its phenotype. Considering the role of environmental exposure on asthma development, an increasing amount of literature has been published on epigenetic modifications associated with this pathology and especially on DNA methylation, in an attempt to better understand its missing heritability. These studies have been conducted in different tissues, but mainly in blood or its peripheral mononuclear cells. However, there is growing evidence that epigenetic changes that occur in one cell type cannot be directly translated into another one. In this review, we compare alterations in DNA methylation from different cells of the immune system and of the respiratory tract. The cell types in which data are obtained influences the global status of alteration of DNA methylation in asthmatic individuals compared to control (an increased or a decreased DNA methylation). Given that several genes were cell-type-specific, there is a great need for comparative studies on DNA methylation from different cells, but from the same individuals in order to better understand the role of epigenetics in asthma pathophysiology. View Full-Text
Keywords: DNA methylation; eosinophil; airway epithelial cell; monocyte; airway smooth muscle cell; lymphocyte B DNA methylation; eosinophil; airway epithelial cell; monocyte; airway smooth muscle cell; lymphocyte B
Show Figures

Figure 1

MDPI and ACS Style

Hudon Thibeault, A.-A.; Laprise, C. Cell-Specific DNA Methylation Signatures in Asthma. Genes 2019, 10, 932.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop