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Open AccessArticle

Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children

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Laboratorio de Medicina Genómica, Hospital Regional Lic. Adolfo López Mateos, ISSSTE. 1321 Universidad Avenue, Álvaro Obregón, Florida, Mexico City P.C0103, Mexico
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Departamento de Métodos Cuantitativos, Facultad de Medicina, Universidad de la República, 2125 General Flores Avenue, Montevideo P.C11800, Uruguay
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División de Inmunogenética, Departamento de Trasplantes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. 15 Vasco de Quiroga Avenue. Mexico City P.C.14080, Mexico
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Coordinación de Vigilancia de Epidemiología, Instituto Mexicano de Seguro Social, 120 Mier y Pesado Street, del Valle Benito Juárez, Mexico City C.P. 03100 Mexico
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Author to whom correspondence should be addressed.
Genes 2019, 10(11), 945; https://doi.org/10.3390/genes10110945
Received: 8 October 2019 / Revised: 12 November 2019 / Accepted: 15 November 2019 / Published: 19 November 2019
Background: Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS). Objective. We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification. Methods: For the GWAS we used the LAT Axiom 1, Affymetrix and 2.5 million single loci from the 1000 Genomes Phase 3 imputation panel. We used a linear model, adjusted by age, sex, and Amerindian ancestry assuming an additive inheritance model. Results. Genome-wide significance (p ≤ 5.0 × 10−8) and 80% of statistical power was reached for associations of two loci in two genes (CERS3 and CYP2E1) to BMI. Also, 11 loci in six genes (ANKS1B, ARNTL2, KCNS3, LMNB1, SRGAP3, TRPC7) reached genome-wide significance for associations to %BF, though not 80% of statistical power. Discussion: None of the SNPs were previously reported as being associated to BMI or %BF. In addition, different loci were found for BMI and %BF. These results highlight the importance of gaining deeper understanding of genetic markers of predisposition to high values for the phenotypes used for obesity diagnosis. View Full-Text
Keywords: GWAS; BMI; percent of body fat; childhood GWAS; BMI; percent of body fat; childhood
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Costa-Urrutia, P.; Colistro, V.; Jiménez-Osorio, A.S.; Cárdenas-Hernández, H.; Solares-Tlapechco, J.; Ramirez-Alcántara, M.; Granados, J.; Ascencio-Montiel, I.J.; Rodríguez-Arellano, M.E. Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children. Genes 2019, 10, 945.

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