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Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription

1
Biological Research Centre, Temesvári krt. 62, H-6726 Szeged, Hungary
2
Doctoral School of Biology, Faculty of Science and Informatics University of Szeged, Dugonics tér 13, H-6720 Szeged, Hungary
*
Authors to whom correspondence should be addressed.
Genes 2019, 10(11), 941; https://doi.org/10.3390/genes10110941
Received: 7 October 2019 / Revised: 7 November 2019 / Accepted: 14 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Transcriptional Regulation of Early Embryogenesis)
Separation of germline cells from somatic lineages is one of the earliest decisions of embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors, which are not transcribed in the soma normally, but a number of testis-specific genes are active in numerous cancer types. During germ cell development, germ-cell-specific genes can be regulated by specific transcription factors, retinoic acid signaling and multimeric protein complexes. Non-canonical polycomb repressive complexes, like ncPRC1.6, play a critical role in the regulation of the activity of germ-cell-specific genes. RING1 and YY1 binding protein (RYBP) is one of the core members of the ncPRC1.6. Surprisingly, the role of Rybp in germ cell differentiation has not been defined yet. This review is focusing on the possible role of Rybp in this process. By analyzing whole-genome transcriptome alterations of the Rybp-/- embryonic stem (ES) cells and correlating this data with experimentally identified binding sites of ncPRC1.6 subunits and retinoic acid receptors in ES cells, we propose a model how germ-cell-specific transcription can be governed by an RYBP centered regulatory network, underlining the possible role of RYBP in germ cell differentiation and tumorigenesis. View Full-Text
Keywords: germ cell differentiation; transcriptional regulation; polycomb repression; Rybp; ncPRC1; Nanog; Oct4; Sall4; ubiquitylation; retinoic acid; apoptosis; meiosis; transcriptome germ cell differentiation; transcriptional regulation; polycomb repression; Rybp; ncPRC1; Nanog; Oct4; Sall4; ubiquitylation; retinoic acid; apoptosis; meiosis; transcriptome
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Bajusz, I.; Henry, S.; Sutus, E.; Kovács, G.; Pirity, M.K. Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription. Genes 2019, 10, 941.

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