Table of Contents
Cells, Volume 8, Issue 2 (February 2019) – 121 articles
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Cover Story (view full-size image) Membrane-bound water channels known as aquaporins facilitate water transport across cellular [...] Read more. Membrane-bound water channels known as aquaporins facilitate water transport across cellular membranes along an osmotic gradient. In eukaryotes, aquaporins have evolved to be post-translationally regulated through gating or trafficking, allowing cells to adapt the membrane water flux in response to cellular or environmental triggers. A common way of controlling aquaporin regulation is through phosphorylation at specific sites. In mammals, this allows the 13 different aquaporin isoforms to be independently regulated in a tissue-dependent manner. This review provides a summary of what is currently known about phosphorylation-dependent regulation of mammalian aquaporins by both gating and trafficking, dissecting the roles of individual phosphorylation sites and of phosphorylation-dependent protein–protein interactions. View this paper.