Table of Contents
Cells, Volume 8, Issue 1 (January 2019)
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Cover Story (view full-size image) A schematic illustration of the EXPAND trial outcomes is shown in the upper part. Both aspects of [...] Read more. A schematic illustration of the EXPAND trial outcomes is shown in the upper part. Both aspects of multiple sclerosis—inflammation and neurodegeneration—were ameliorated by the spingosine 1 phosphate receptor modulator siponimod/BAF312 (Novartis). The lower part of the figures demonstrates the proposed mode of action of siponimod. Note that following this concept, the anti-inflammatory activity of siponimod is at least in part due to direct interactions with brain cells. Since several studies have demonstrated that degenerative events within the central nervous system can trigger the recruitment of peripheral immune cells into the brain, siponimod-mediated protection of brain damage secondarily results in less severe inflammation. View this paper.