Molecular Role of PARP in Health and Disease

Dear Colleagues,

Poly(ADP-ribose) polymerases (PARPs or ARTDs) represent a 17-member family characterized by a common catalytic subunit. PARPs use NAD+ as substrate and PARP1 or PARP2, when activated can limit NAD+ availability in cells to other enzymes. PARPs and their product, poly(ADP-ribose) regulates transcription and chromatin structure. PARP enzymes have crucial role in regulating DNA repair making major PARP enzymes attractive targets for pharmacological inhibition. In the past few years, PARP inhibitors have entered the clinical use, while at the same time, more specific PARP inhibitors are being develop to target only tankyrases or mono-ADP-ribose polymerases among the PARP family members. In addition to DNA repair and oncological transformation, PARPs influence a plethora of other cellular (patho)physiological processes from metabolism to virus–host interactions.

Dr. Péter Bay
Guest Editor

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