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Special Issue "Molecular Role of PARP in Health and Disease"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (10 June 2019).
Interests: poly(ADP-ribose)polymerase; PARP; mitochondria; sirtuin; metabolism
Special Issues and Collections in MDPI journals
Poly(ADP-ribose) polymerases (PARPs or ARTDs) represent a 17-member family characterized by a common catalytic subunit. PARPs use NAD+ as substrate and PARP1 or PARP2, when activated can limit NAD+ availability in cells to other enzymes. PARPs and their product, poly(ADP-ribose) regulates transcription and chromatin structure. PARP enzymes have crucial role in regulating DNA repair making major PARP enzymes attractive targets for pharmacological inhibition. In the past few years, PARP inhibitors have entered the clinical use, while at the same time, more specific PARP inhibitors are being develop to target only tankyrases or mono-ADP-ribose polymerases among the PARP family members. In addition to DNA repair and oncological transformation, PARPs influence a plethora of other cellular (patho)physiological processes from metabolism to virus–host interactions.
Dr. Péter Bay
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- PARP inhibitors
- protein degradation
- postrranslational modifications
- DNA repair
- cell division
- cell cycle
- cytostatic treatment
- synthetic lethality
- enzyme trapping
- cell death
- oxidative stress
- viral infection
- energy sensors
- circadian rhtythm
- metabolic diseases