Special Issue "Emerging Trends in Metal Biochemistry"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 April 2019).
Interests: copper ions; membrane proteins; biophysics; membrane-associated scaffolds; electron microscopy; digital image reconstruction
Stereotypically, “biochemistry” is associated with the properties and roles of proteins, nucleic acids, carbohydrates, lipids and the thousands of chemical reactions that occur within the chemical engine that keeps cells alive. Often missing from this picture are the myriad contributions of metal ions that are woven so deeply into the chemistry of life that imbalances in their homeostasis invariably derail cellular function, often with lethal consequences. What makes metals universally useful and indispensable within biology are their distinct chemical behaviors that allow them to support every aspect of life. In fact, there is not one cellular function that does not—in one way or another—rely on the presence of metal ions, be it through passive screening of electrostatics on biopolymer surfaces, direct regulation of biopolymer dynamics, stabilization of protein domains, catalysis, generation of voltages, or cellular signalling. Yet despite its fundamental importance, the biochemistry of metals at large remains understudied and underappreciated—metals, in short, are often taken for granted. However, as life sciences advance, new and sometimes unexpected roles of metals are discovered at an accelerating pace, slowly but surely moving a spotlight onto this exciting field within biochemistry.
Through a mix of review and original articles, the scope of this Special Issue is to highlight recent and emerging trends in the biochemistry of five pivotal metals: calcium, copper, iron, manganese, and zinc. The goal is to share passion for metals by providing an integrated view that spans from cell to systems biology, from biophysics to pharmacology, pathology and clinical applications, showcasing how study of metal biochemistry will make increasingly important contributions to our understanding of life’s mysteries.
Prof. Dr. Vinzenz M. Unger
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- metal homeostasis
- metal biology
- metal pharmacology
- clinical imaging of metals
- bio-inorganic chemistry
- metalloprotein structure
- trace metals
- electron microscopy
- PET imaging
- X-ray fluorescent microscopy
- Fe-S cluster
- neurodegenerative disease
- metals in plants
- reactive oxygen species