Next Article in Journal
Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation
Next Article in Special Issue
Nuclear Progestin Receptor Phosphorylation by Cdk9 Is Required for the Expression of Mmp15, a Protease Indispensable for Ovulation in Medaka
Previous Article in Journal
The Centriolar Adjunct–Appearance and Disassembly in Spermiogenesis and the Potential Impact on Fertility
Previous Article in Special Issue
Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling
 
 
Article

Wound Healing Fluid Reflects the Inflammatory Nature and Aggressiveness of Breast Tumors

1
Division of Surgical Oncology, Breast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy
2
Molecular Targeting Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy
3
Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(2), 181; https://doi.org/10.3390/cells8020181
Received: 14 December 2018 / Revised: 8 February 2019 / Accepted: 14 February 2019 / Published: 19 February 2019
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
Wound healing fluid that originates from breast surgery increases the aggressiveness of cancer cells that remain after the surgery. We determined the effects of the extent of surgery and tumor-driven remodeling of the surrounding microenvironment on the ability of wound-healing to promote breast cancer progression. In our analysis of a panel of 34 cytokines, chemokines, and growth factors in wound healing fluid, obtained from 27 breast carcinoma patients after surgery, the levels of several small molecules were associated with the extent of cellular damage that was induced by surgery. In addition, the composition of the resulting wound healing fluid was associated with molecular features of the removed tumor. Specifically, IP-10, IL-6, G-CSF, osteopontin, MIP-1a, MIP-1b, and MCP1-MCAF were higher in more aggressive tumors. Altogether, our findings indicate that the release of factors that are induced by removal of the primary tumor and subsequent wound healing is influenced by the extent of damage due to surgery and the reactive stroma that is derived from the continuously evolving network of interactions between neoplastic cells and the microenvironment, based on the molecular characteristics of breast carcinoma cells. View Full-Text
Keywords: wound; extracellular matrix; cytokines; breast cancer; surgery; IL-6; G-CSF; osteopontin wound; extracellular matrix; cytokines; breast cancer; surgery; IL-6; G-CSF; osteopontin
Show Figures

Graphical abstract

MDPI and ACS Style

Agresti, R.; Triulzi, T.; Sasso, M.; Ghirelli, C.; Aiello, P.; Rybinska, I.; Campiglio, M.; Sfondrini, L.; Tagliabue, E.; Bianchi, F. Wound Healing Fluid Reflects the Inflammatory Nature and Aggressiveness of Breast Tumors. Cells 2019, 8, 181. https://doi.org/10.3390/cells8020181

AMA Style

Agresti R, Triulzi T, Sasso M, Ghirelli C, Aiello P, Rybinska I, Campiglio M, Sfondrini L, Tagliabue E, Bianchi F. Wound Healing Fluid Reflects the Inflammatory Nature and Aggressiveness of Breast Tumors. Cells. 2019; 8(2):181. https://doi.org/10.3390/cells8020181

Chicago/Turabian Style

Agresti, Roberto, Tiziana Triulzi, Marianna Sasso, Cristina Ghirelli, Piera Aiello, Ilona Rybinska, Manuela Campiglio, Lucia Sfondrini, Elda Tagliabue, and Francesca Bianchi. 2019. "Wound Healing Fluid Reflects the Inflammatory Nature and Aggressiveness of Breast Tumors" Cells 8, no. 2: 181. https://doi.org/10.3390/cells8020181

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop