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The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock

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Department of Translational Medicine, Università degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Piedmont, Italy
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Emergency Department, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Piedmont, Italy
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CAAD, IRCAD, Department of Health Sciences, Università degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Piedmont, Italy
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Division of Nephrology and Transplantation, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Piedmont, Italy
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Division of Anesthesiology and Reanimation, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Piedmont, Italy
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Division of Internal Medicine, “Sant’Andrea” Hospital, Corso Abbiate 21, 13100 Vercelli (VC), Piedmont, Italy
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Division of Anesthesiology and Reanimation, Department of Medical and Surgical Sciences, Università degli Studi Magna Grecia, 88100 Catanzaro (CZ), Calabria, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(2), 174; https://doi.org/10.3390/cells8020174
Received: 6 December 2018 / Revised: 7 February 2019 / Accepted: 17 February 2019 / Published: 18 February 2019
(This article belongs to the Special Issue Adding New Pieces in the Osteopontin Puzzle)
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). We conducted a single-centre prospective observational study in an Italian ED where we enrolled 102 consecutive patients presenting with suspected infection and qSOFA ≥ 2. OPN plasma concentration was found to be an independent predictor of sepsis (OR = 1.020, 95% CI 1.002–1.039, p = 0.031) and the diagnostic receiver operating characteristic (ROC) curve resulted in an area under the curve (AUC) of 0.878. OPN levels were positively correlated to plasma creatinine (r = 0.401 with p = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients. The analysis of 30-days mortality showed no significant difference in OPN levels between alive and dead patients (p = 0.482). In conclusion, a single determination of OPN concentration helped to identify patients with sepsis in the ED, but it was not able to predict poor prognosis in our cohort of patients. View Full-Text
Keywords: Osteopontin; biomarkers; sepsis; Emergency Department; diagnosis; risk stratification; prognosis Osteopontin; biomarkers; sepsis; Emergency Department; diagnosis; risk stratification; prognosis
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Castello, L.M.; Baldrighi, M.; Molinari, L.; Salmi, L.; Cantaluppi, V.; Vaschetto, R.; Zunino, G.; Quaglia, M.; Bellan, M.; Gavelli, F.; Navalesi, P.; Avanzi, G.C.; Chiocchetti, A. The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock. Cells 2019, 8, 174.

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