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Crystals, Volume 9, Issue 11 (November 2019)
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Cover Story (view full-size image) Carbamazepine (CBZ), a widely used antiepileptic, is known to be sensitive to light. [...] Read more. Carbamazepine (CBZ), a widely used antiepileptic, is known to be sensitive to light. Cocrystallization can alter the physicochemical properties of the active pharmaceutical ingredient without modifying its intrinsic structure. In the present study, we prepared three cocrystals, including two polymorphs, of CBZ and investigated their photostabilities compared with that of the CBZ polymorphs. Cocrystals of CBZ with succinic acid (CBZ–SUC) and saccharin (CBZ–SAC form I) significantly suppressed the discoloration and degradation of CBZ compared to conventional solid forms. The molecular mobility significantly decreased following the formation of CBZ–SUC and CBZ–SAC form I and resulted in higher photostability. Cocrystallization was proven to be an effective approach to improving the photostability of a photolabile drug. View this paper