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Cancers, Volume 15, Issue 10

May-2 2023 - 206 articles

Cover Story: The quest for more augmented and durable responses to melanoma immunotherapy has fueled recent efforts toward identifying novel immune checkpoint (IC) molecules that could be potentially targeted. The dynamic crosstalk between melanoma and immune effector cells is based on a complex network of many implicated IC molecules beyond PD-1 and CTLA-4, including LAG-3, TIGIT, TIM-3, VISTA, IDO1-2/TDO, CD27/70, CD39/73, HVEM/BTLA/CD160 and B7-H3. This paper explores all emerging IC molecules with emphasis on their co-inhibitory or co-stimulatory properties, with the aim of presenting all currently available clinical and preclinical data on their therapeutic potential. Understanding these IC-mediated pathways presents a unique opportunity to get a step closer to realizing “personalized immunotherapy”. View this paper
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Articles (206)

  • Article
  • Open Access
2,546 Views
11 Pages

Clinical Outcomes of Patients with Metastatic Breast Cancer Treated with Hypo-Fractionated Liver Radiotherapy

  • Melinda Mushonga,
  • Joelle Helou,
  • Jessica Weiss,
  • Laura A. Dawson,
  • Rebecca K. S. Wong,
  • Ali Hosni,
  • John Kim,
  • James Brierley,
  • C. Anne Koch and
  • Khalid Alrabiah
  • + 3 authors

19 May 2023

Purpose: To retrospectively review the clinical outcomes of patients with metastatic breast cancer (MBCa) following liver directed ablative intent radiotherapy (RT). Methods: Demographics, disease and treatment characteristics of patients with MBCa w...

  • Review
  • Open Access
53 Citations
7,086 Views
27 Pages

Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy

  • Vinith Johnson,
  • Sunil Vasu,
  • Uday S. Kumar and
  • Manoj Kumar

19 May 2023

Extracellular vesicles (EVs) are lipid bilayer-enclosed bodies secreted by all cell types. EVs carry bioactive materials, such as proteins, lipids, metabolites, and nucleic acids, to communicate and elicit functional alterations and phenotypic change...

  • Review
  • Open Access
21 Citations
7,691 Views
23 Pages

How Does Environmental and Occupational Exposure Contribute to Carcinogenesis in Genitourinary and Lung Cancers?

  • Massimiliano Cani,
  • Fabio Turco,
  • Simona Butticè,
  • Ursula Maria Vogl,
  • Consuelo Buttigliero,
  • Silvia Novello and
  • Enrica Capelletto

19 May 2023

Environmental and occupational exposures have been associated with an increased risk of different types of cancers, although the exact mechanisms of higher carcinogenesis risk are not always well understood. Lung cancer is the leading cause of global...

  • Article
  • Open Access
47 Citations
5,122 Views
16 Pages

Efficient Brain Tumor Detection with Lightweight End-to-End Deep Learning Model

  • Mohamed Hammad,
  • Mohammed ElAffendi,
  • Abdelhamied A. Ateya and
  • Ahmed A. Abd El-Latif

19 May 2023

In the field of medical imaging, deep learning has made considerable strides, particularly in the diagnosis of brain tumors. The Internet of Medical Things (IoMT) has made it possible to combine these deep learning models into advanced medical device...

  • Review
  • Open Access
15 Citations
3,820 Views
43 Pages

Role of AI and Radiomic Markers in Early Diagnosis of Renal Cancer and Clinical Outcome Prediction: A Brief Review

  • Mohamed Shehata,
  • Rasha T. Abouelkheir,
  • Mallorie Gayhart,
  • Eric Van Bogaert,
  • Mohamed Abou El-Ghar,
  • Amy C. Dwyer,
  • Rosemary Ouseph,
  • Jawad Yousaf,
  • Mohammed Ghazal and
  • Sohail Contractor
  • + 1 author

19 May 2023

Globally, renal cancer (RC) is the 10th most common cancer among men and women. The new era of artificial intelligence (AI) and radiomics have allowed the development of AI-based computer-aided diagnostic/prediction (AI-based CAD/CAP) systems, which...

  • Review
  • Open Access
9 Citations
5,048 Views
34 Pages

Metal-Based Anticancer Complexes and p53: How Much Do We Know?

  • Samah Mutasim Alfadul,
  • Egor M. Matnurov,
  • Alexander E. Varakutin and
  • Maria V. Babak

19 May 2023

P53 plays a key role in protecting the human genome from DNA-related mutations; however, it is one of the most frequently mutated genes in cancer. The P53 family members p63 and p73 were also shown to play important roles in cancer development and pr...

  • Review
  • Open Access
8 Citations
2,913 Views
29 Pages

19 May 2023

According to the World Health Organization, every year, an estimated 400,000+ new cancer cases affect children under the age of 20 worldwide. Unlike adult cancers, pediatric cancers develop very early in life due to alterations in signaling pathways...

  • Review
  • Open Access
3 Citations
2,591 Views
14 Pages

The Lack of Standardized Outcomes for Surgical Salvage of HPV-Positive Recurrent Oropharyngeal Squamous Cell Carcinoma: A Systematic Scoping Review

  • April N. Taniguchi,
  • Sarah R. Sutton,
  • Shaun A. Nguyen,
  • Alexandra E. Kejner and
  • William G. Albergotti

19 May 2023

Although HPV status is known to provide an improved prognosis in initial treatments of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), it is unclear how it affects patients who receive salvage surgery (SS), which has historically poor sur...

  • Article
  • Open Access
10 Citations
1,960 Views
14 Pages

Patient’s Desire and Real Availability Concerning Supportive Measures Accompanying Radical Prostatectomy: Differences between Certified Prostate Cancer Centers and Non-Certified Centers Based on Patient-Reported Outcomes within the Cross-Sectional Study Improve

  • Ingmar Wolff,
  • Martin Burchardt,
  • Julia Peter,
  • Christian Thomas,
  • Danijel Sikic,
  • Christian Fiebig,
  • Sören Promnitz,
  • Bernd Hoschke,
  • Maximilian Burger and
  • Marco J. Schnabel
  • + 5 authors

19 May 2023

Certification as a prostate cancer center requires the offer of several supportive measures to patients undergoing radical prostatectomy (RP). However, it remains unclear how patients estimate the relevance of these measures and whether the availabil...

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Cancers - ISSN 2072-6694