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Cancers 2018, 10(9), 317; https://doi.org/10.3390/cancers10090317

Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers

1
Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
2
Department of Microbiology, College of Natural Sciences, Dankook University, Cheonan 31116, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 August 2018 / Revised: 27 August 2018 / Accepted: 4 September 2018 / Published: 7 September 2018
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Abstract

Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal tissues in dogs. By comprehensive transcriptome analysis, 351 differentially expressed genes (DEGs) were identified in overall canine MGCs. Based on the DEGs, comparative analysis revealed correlation existing among the three histological subtypes of canine MGC (ductal, simple, and complex) and four molecular subtypes of human BC (HER2+, ER+, ER&HER2+, and TNBC). Eight DEGs shared by all three subtypes of canine MGCs had been previously reported as cancer-associated genes in human studies. Gene ontology and pathway analyses using the identified DEGs revealed that the biological processes of cell proliferation, adhesion, and inflammatory responses are enriched in up-regulated MGC DEGs. In contrast, fatty acid homeostasis and transcription regulation involved in cell fate commitment were down-regulated in MGC DEGs. Moreover, correlations are demonstrated between upstream promoter transcripts and DEGs. Canine MGC- and subtype-enriched gene expression allows us to better understand both human BC and canine MGC, yielding new insight into the development of biomarkers and targets for both diseases. View Full-Text
Keywords: transcriptome; dog; mammary gland tumor; breast cancer; RNA-seq transcriptome; dog; mammary gland tumor; breast cancer; RNA-seq
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Lee, K.-H.; Park, H.-M.; Son, K.-H.; Shin, T.-J.; Cho, J.-Y. Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers. Cancers 2018, 10, 317.

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