Table of Contents
Cancers, Volume 10, Issue 8 (August 2018)
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Cover Story (view full-size image) The tumor microenvironment (TME) of epithelial ovarian cancer is a complex network of cancer cells [...] Read more. The tumor microenvironment (TME) of epithelial ovarian cancer is a complex network of cancer cells surrounded by immune cells, such as T (CD4+, CD8+) and B lymphocytes (B cells); regulatory lymphocytes (CD4+ Treg, CD8+ Treg and Breg cells); natural killer cells (NKs); pro-inflammatory type 1 macrophages (M1) and tumor associated macrophages (TAMs); dendritic cells (DCs); myeloid-derived suppressor cells (MDSCs); and other components including cancer associated fibroblasts (CAFs) and the adipocytes in the omentum. Primary tumors, metastasis, and ascites are enriched with different components, making each TME a unique case. In this issue, we describe the composition of the TME, how it can influence antitumoral responses, and current EOC models. View this paper