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No Increase in Colon Cancer Risk Following Induction with Neu5Gc-Bearing Rabbit Anti-T Cell IgG (ATG) in Recipients of Kidney Transplants

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, 44093 Nantes, France
Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, 44093 Nantes, France
Institute of Immunology, Heidelberg University, 69120 Heidelberg, Germany
Author to whom correspondence should be addressed.
Cancers 2018, 10(9), 324;
Received: 26 July 2018 / Revised: 10 September 2018 / Accepted: 11 September 2018 / Published: 12 September 2018
PDF [548 KB, uploaded 12 September 2018]


Because of a mutation of the gene allowing the synthesis of the Neu5Gc form of neuraminidic acid, humans lack the Neu5Gc present in other mammals and develop anti-Neu5Gc. However, humans can absorb dietary Neu5Gc and normal colon epithelium displays minute amounts of Neu5Gc. The potential “physiological” formation of in situ immune complexes has been proposed as a risk factor for colon cancer and as the link between red meat-rich diet and colon carcinoma. In this article, we took advantage of evidence that polyclonal rabbit IgG (ATG) elicits an immune response against Neu5Gc and we consulted a large data base of allograft recipients treated or not with animal-derived IgG to discuss this hypothesis. Based on data from 173,960 and 38,505 patients without and with ATG induction, respectively, we found no evidence that exposure to higher levels of anti-Neu5Gc is associated with a higher incidence of colon carcinoma. View Full-Text
Keywords: colon cancer; anti-Neu5Gc; red meat colon cancer; anti-Neu5Gc; red meat

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Soulillou, J.-P.; Süsal, C.; Döhler, B.; Opelz, G. No Increase in Colon Cancer Risk Following Induction with Neu5Gc-Bearing Rabbit Anti-T Cell IgG (ATG) in Recipients of Kidney Transplants. Cancers 2018, 10, 324.

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