Micromachines, Volume 11, Issue 12
2020 December - 108 articles
Cover Story: Angiogenesis is a physiological process in which new blood vessels form from pre-existing blood vessels. The direction of angiogenesis is important both during early embryonic development and in later adulthood. One of the important factors for determining the direction of angiogenesis is the complex biochemical gradient distribution. This article presents a microfluidic device which can trap an endothelial cell spheroid in the trapping site sandwiched by two extracellular matrix gels located at the upper and lower side of the spheroid. This device can form different biochemical gradients by applying target biochemicals separately in the upper and the lower channels, enabling the study of the angiogenic sprouting under various biochemical gradients in different directions. View this paper
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Micromachines - ISSN 2072-666X