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Toxins, Volume 16, Issue 1

2024 January - 61 articles

Cover Story: This study investigates the protective effect of the chaperonin TRiC/CCT inhibitor, HSF1A, against pertussis toxin (PT) produced by Bordetella pertussis, the causative agent of whooping cough. TRiC/CCT is a cytosolic protein-folding complex. Previous research highlighted its significance in the functionality of related bacterial toxins. Our study reveals a novel interaction between PTS1 and CCT5, a subunit of the TRiC/CCT chaperonin complex. HSF1A effectively reduces PTS1-mediated ADP-ribosylation of Gαi, the specific intracellular substrate of PT. HSF1A does not impact enzyme activity in vitro or PT cell binding but reduces cytosolic PTS1 levels. Accordingly, HSF1A mitigates adverse effects of PT on inhibitory GPCR/cAMP signaling, suggesting therapeutic potential for countering PT-mediated pathogenicity. View this paper
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Articles (61)

  • Article
  • Open Access
3 Citations
4,043 Views
13 Pages

Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells

  • Willemien F. J. Hof,
  • Miranda Visser,
  • Joyce J. de Jong,
  • Marian N. Rajasekar,
  • Jan Jacob Schuringa,
  • Inge A. M. de Graaf,
  • Daan J. Touw and
  • Bart G. J. Dekkers

22 January 2024

Amanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloide...

  • Article
  • Open Access
3 Citations
2,795 Views
13 Pages

Establishing a Receptor Binding Assay for Ciguatoxins: Challenges, Assay Performance and Application

  • Lisbet Díaz-Asencio,
  • Donaida Chamero-Lago,
  • Gabriel L. Rojas-Abrahantes,
  • Carlos M. Alonso-Hernández and
  • Marie-Yasmine Dechraoui Bottein

22 January 2024

Ciguatera, a global issue, lacks adequate capacity for ciguatoxin analysis in most affected countries. The Caribbean region, known for its endemic ciguatera and being home to a majority of the global small island developing states, particularly needs...

  • Article
  • Open Access
3 Citations
4,067 Views
13 Pages

Longitudinal Assessment of Facial Hyperhidrosis Management: Evaluating the Utility and Quality of Life Improvements following Botulinum Toxin Injection

  • Catalin Prodan-Barbulescu,
  • Luca Castiglione,
  • Sonia Roxana Burtic,
  • Marius Murariu,
  • Shruta Reddy,
  • Ovidiu Rosca,
  • Felix Bratosin,
  • Camelia Melania Fizedean,
  • Pavel Krupyshev and
  • Ileana Enatescu

21 January 2024

Facial hyperhidrosis is a debilitating condition that can severely impact the quality of life. This study aimed to assess the long-term utility of Botulinum toxin type A therapy (BTA) for facial hyperhidrosis and its impact on quality of life over a...

  • Review
  • Open Access
18 Citations
5,562 Views
27 Pages

Practical Strategies to Reduce Ochratoxin A in Foods

  • Hyun Jung Lee,
  • Hae Dun Kim and
  • Dojin Ryu

20 January 2024

Ochratoxin A (OTA), a potent nephrotoxin, is one of the most deleterious mycotoxins, with its prevalence in agricultural crops and their processed foods around the world. OTA is a major concern to food safety, as OTA exposure through dietary intake m...

  • Article
  • Open Access
14 Citations
3,761 Views
17 Pages

A Magnetic Reduced Graphene Oxide Nanocomposite: Synthesis, Characterization, and Application for High-Efficiency Detoxification of Aflatoxin B1

  • Chushu Zhang,
  • Haixiang Zhou,
  • Shining Cao,
  • Jing Chen,
  • Chunjuan Qu,
  • Yueyi Tang,
  • Mian Wang,
  • Lifei Zhu,
  • Xiaoyue Liu and
  • Jiancheng Zhang

19 January 2024

(1) Background: Safety problems associated with aflatoxin B1 (AFB1) contamination have always been a major threat to human health. Removing AFB1 through adsorption is considered an attractive remediation technique. (2) Methods: To produce an adsorben...

  • Article
  • Open Access
7 Citations
4,082 Views
14 Pages

Development of a Biosensor to Detect Venom of Malayan Krait (Bungarus candidus)

  • Kiattawee Choowongkomon,
  • Janeyuth Chaisakul,
  • Supaphorn Seetaha,
  • Taksa Vasaruchapong,
  • Wayne C. Hodgson,
  • Natchaya Rasri,
  • Katechawin Chaeksin,
  • Sattawat Boonchaleaw and
  • Nattapon Sookprasert

19 January 2024

Malayan krait (Bungarus candidus) envenoming is a cause of significant morbidity and mortality in many Southeast Asian countries. If intubation and specific antivenom administration are delayed, the most significant life-threatening outcome may be th...

  • Review
  • Open Access
8 Citations
4,036 Views
17 Pages

Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins

  • Kirsten L. McMahon,
  • Irina Vetter and
  • Christina I. Schroeder

18 January 2024

µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development. A limiting factor in their therapeutic development...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,222 Views
22 Pages

Cytotoxic Effects of Major and Emerging Mycotoxins on HepaRG Cells and Transcriptomic Response after Exposure of Spheroids to Enniatins B and B1

  • France Coulet,
  • Monika Coton,
  • Cristian Iperi,
  • Marine Belinger Podevin,
  • Emmanuel Coton and
  • Nolwenn Hymery

18 January 2024

Mycotoxins, produced by fungi, frequently occur at different stages in the food supply chain between pre- and postharvest. Globally produced cereal crops are known to be highly susceptible to contamination, thus constituting a major public health con...

  • Article
  • Open Access
25 Citations
4,819 Views
18 Pages

An Occurrence Study of Mycotoxins in Plant-Based Beverages Using Liquid Chromatography–Mass Spectrometry

  • Romans Pavlenko,
  • Zane Berzina,
  • Ingars Reinholds,
  • Elena Bartkiene and
  • Vadims Bartkevics

17 January 2024

Mycotoxins are toxic mold metabolites that can adversely affect human and animal health. More than 400 mycotoxins have been identified so far. Cereals and nuts are the predominant mycotoxin-contaminated foodstuffs. Plant-based drinks produced from ce...

  • Article
  • Open Access
5 Citations
3,762 Views
16 Pages

Exploring the Biocontrol Capability of Non-Mycotoxigenic Strains of Penicillium expansum

  • Belén Llobregat,
  • Luis González-Candelas and
  • Ana-Rosa Ballester

17 January 2024

Penicillium expansum is one the major postharvest pathogens of pome fruit during postharvest handling and storage. This fungus also produces patulin, which is a highly toxic mycotoxin that can contaminate infected fruits and their derived products an...

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Toxins - ISSN 2072-6651