Table of Contents
Toxins, Volume 12, Issue 4 (April 2020) – 69 articles
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Cover Story (view full-size image) Bacillus thuringiensis cytolytic toxin (Cyt) directly interacts with membrane lipids resulting in [...] Read more. Bacillus thuringiensis cytolytic toxin (Cyt) directly interacts with membrane lipids resulting in cytolytic action. Threonine at position 144 (T144) of Cyt2Aa2 is proposed to play an important role for lipid binding. Investigations using atomic force microscopy (AFM) revealed that the low hemolytic T144A mutant and the wild type bind onto different areas of the erythrocyte membrane. The T144A mutant was unable to bind to phosphatidylcholine lipid (POPC) bilayer. However, addition of cholesterol (Chol) or sphingomyelin (SM) to the POPC bilayer promoted binding of the T144A mutant. The top panel is a model lipid membrane and lower panel is an AFM image.View this paper.