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Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins

Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Suite A-1106 MCN, Nashville, TN 37232, USA
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Toxins 2020, 12(4), 269; https://doi.org/10.3390/toxins12040269
Received: 29 March 2020 / Revised: 16 April 2020 / Accepted: 18 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Treatment of Dystonia with Botulinum Toxins)
Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing. View Full-Text
Keywords: blepharospasm; oromandibular dystonia; Meige syndrome; botulinum toxin; OnabotulinumtoxinA; AbobotulinumtoxinA; IncobotulinumtoxinA; RimabotulinumtoxinB; DaxibotulinumtoxinA blepharospasm; oromandibular dystonia; Meige syndrome; botulinum toxin; OnabotulinumtoxinA; AbobotulinumtoxinA; IncobotulinumtoxinA; RimabotulinumtoxinB; DaxibotulinumtoxinA
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Hassell, T.J.; Charles, D. Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins. Toxins 2020, 12, 269.

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