Neurology International, Volume 15, Issue 4
2023 December - 23 articles
Cover Story: The coexistence of chronic pain and depressive symptoms forms an intrinsic relationship that affects executive and cognitive functions. This review delves into the pivotal role of the microcircuit formed between the lateral habenula (LHb) and the ventral tegmental area (VTA) in these dysfunctions. Dysregulation in VTA dopamine transmission, linked to LHb hyperactivity, may exacerbate cognitive issues related to pain. This review explores the organizational and structural connectivity aspects of the LHb-VTA microcircuit and its implications for pain-related cognitive dysfunction, offering potential avenues for targeted therapeutic interventions. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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