Dear Colleagues, 

Glioblastoma is a diffusely infiltrative malignant brain tumor that leads to significant morbidity and mortality among affected patients. The new 2021 WHO Classification of Tumors of the Central Nervous System opened new horizons in molecular changes and in clinical and surgical practice.

Due to the extremely poor prognosis, it is imperative to investigate new and altered molecular mechanisms that may be involved in glioblastoma pathogenesis. Despite recent new studies and technologies, due to unfavorable prognosis, it is essential to look for novel, potentially change molecular processes involved in the disease's etiology and progression that may lead to the creation of more effective therapeutic strategies. Research on novel adjuvant agents, advanced personalized molecular diagnostics and response to novel targeted molecular therapies for the treatment of glioblastoma is promising.

This special issue covers all aspects of glioblastoma, including surgical innovations, original research on current and experimental treatment options, studies on molecular characteristics of glioblastoma, as well as mechanisms underlying growth inhibition: apoptosis, autophagy, necrosis.

The aim of this special issue will be to contribute to a better understanding of tumor heterogeneity/microenvironment, the different molecular signature in GBM subtypes and the relative contributions of glioma stem cells. Original papers, systematic reviews, meta-analyses and quality-of-life focused stereotactic radiosurgery, brain surgery, interstitial laser thermotherapy and oncology studies on this topic of interest are welcome.

Dr. Nicola Montemurro
Guest Editor

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• glioblastoma cell line
• target therapy
• grosso-total resection
• molecular markers
• glioblastoma
• signalling pathways
• epigenomics
• tumor heterogeneity
• oncogenes
• exosomes
• tumor microenvironment