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Neurology International, Volume 15, Issue 3

September 2023 - 27 articles

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Cover Story: Long-COVID has been a major consequence of the COVID-19 pandemic and continues to be a worldwide health concern. In particular, neurologic symptoms that linger beyond the acute phase of the disease can cause drastic negative effects on a patient’s ability to function and quality of life. Among the major central nervous system clinical manifestations of long-COVID are brain fog, headache, sleep disturbances, fatigue and depression. Sensorimotor symptoms experienced beyond 12 weeks after initial COVID-19 infection include neuropathic pain, myalgias and muscle weakness. Proposed pathological mechanisms underlying these symptoms generally focus on neuroinflammatory and systemic inflammatory processes, immune dysregulation and cerebral metabolic dysfunction. Treatment options are limited and a focus of intensive research. View this paper

Articles (27)

  • Case Report
  • Open Access
3 Citations
2,660 Views
9 Pages

18 September 2023

Immune thrombocytopenia (ITP) is an autoimmune blood disorder characterised by isolated severe thrombocytopenia. Arterial thrombotic events, such as acute ischaemic stroke (AIS), are rare complications. A 56-year-old woman with chronic ITP on eltromb...

  • Review
  • Open Access
8 Citations
8,259 Views
17 Pages

13 September 2023

Migraine, a prevalent neurological condition and the third most common disease globally, places a significant economic burden on society. Despite extensive research efforts, the precise underlying mechanism of the disease remains incompletely compreh...

  • Review
  • Open Access
11 Citations
3,500 Views
19 Pages

11 September 2023

Hypomyelinating leukodystrophies (HLDs) represent a group of congenital rare diseases for which the responsible genes have been identified in recent studies. In this review, we briefly describe the genetic/molecular mechanisms underlying the pathogen...

  • Systematic Review
  • Open Access
5 Citations
3,306 Views
15 Pages

Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis

  • Monika Zawadka-Kunikowska,
  • Łukasz Rzepiński,
  • Małgorzata Tafil-Klawe,
  • Nicola Veronese,
  • Mario Barbagallo,
  • Mario Habek and
  • Nils E. Gilhus

8 September 2023

The aim of this systematic review with meta-analysis was to determine differences in cardiovascular autonomic parameters between patients with myasthenia gravis (MG) and healthy controls (HCs). Two reviewers searched four electronic databases, namely...

  • Article
  • Open Access
9 Citations
2,428 Views
11 Pages

A Comparative Analysis of Symmetry Indices for Spatiotemporal Gait Features in Early Parkinson’s Disease

  • Erasmia Giannakou,
  • Styliani Fotiadou,
  • Vassilios Gourgoulis,
  • Georgios Mavrommatis and
  • Nikolaos Aggelousis

7 September 2023

This study compared the five most commonly used equations for calculating gait symmetry in discrete variables among Parkinson’s disease patients. Twelve patients (five women and seven men) performed ten consecutive gait trials on a 10 m walkway...

  • Article
  • Open Access
1 Citations
2,186 Views
12 Pages

Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study

  • Maria Papasavva,
  • Michail Vikelis,
  • Vasileios Siokas,
  • Martha-Spyridoula Katsarou,
  • Emmanouil V. Dermitzakis,
  • Athanasios Raptis,
  • Efthimios Dardiotis and
  • Nikolaos Drakoulis

5 September 2023

Migraine is a common primary headache disorder with both environmental and genetic inputs. Cumulative evidence indicates an association between vitamin D and headache. Unravelling the precise role of vitamin D and its receptor in the pathophysiology...

  • Protocol
  • Open Access
6 Citations
2,699 Views
11 Pages

Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol

  • Triantafyllos K. Doskas,
  • Foteini Christidi,
  • Kanellos C. Spiliopoulos,
  • Dimitrios Tsiptsios,
  • George D. Vavougios,
  • Anna Tsiakiri,
  • Theofanis Vorvolakos,
  • Christos Kokkotis,
  • Ioannis Iliopoulos and
  • Nikolaos Aggelousis
  • + 1 author

1 September 2023

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can...

  • Review
  • Open Access
20 Citations
21,861 Views
54 Pages

Migraine: Advances in the Pathogenesis and Treatment

  • Horia Pleș,
  • Ioan-Alexandru Florian,
  • Teodora-Larisa Timis,
  • Razvan-Adrian Covache-Busuioc,
  • Luca-Andrei Glavan,
  • David-Ioan Dumitrascu,
  • Andrei Adrian Popa,
  • Andrei Bordeianu and
  • Alexandru Vlad Ciurea

31 August 2023

This article presents a comprehensive review on migraine, a prevalent neurological disorder characterized by chronic headaches, by focusing on their pathogenesis and treatment advances. By examining molecular markers and leveraging imaging techniques...

  • Brief Report
  • Open Access
2 Citations
2,060 Views
8 Pages

30 August 2023

Serum growth differentiation factor 15 (GDF-15) levels are elevated in patients with Parkinson’s disease (PD) and may help differentiate these patients from healthy individuals. We aimed to clarify whether serum GDF-15 levels can help different...

  • Article
  • Open Access
4 Citations
2,608 Views
30 Pages

25 August 2023

Atrial fibrillation (AF) significantly contributes to acute ischaemic stroke (AIS), yet its precise influence on clinical outcomes post-intravenous thrombolysis (IVT) and post-endovascular thrombectomy (EVT) has remained elusive. Furthermore, the ove...

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