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Viruses, Volume 13, Issue 2

February 2021 - 213 articles

Cover Story: Clonal expansion of hepatocytes, a risk factor for the development of hepatocellular carcinoma (HCC), occurs in the liver during chronic hepatitis B virus infection. Hepatocytes are self-renewing, and the emergence of HCC from hepatocytes involves initiation (genetic) and promotion (cell proliferation). Genetic changes are due to random integration of HBV DNA and oxidative DNA damage caused by chronic inflammation. Promotion is due to replacement of hepatocytes killed by the immune response leading to loss of some hepatocyte lineages and expansion of others, including hepatocytes that no longer sustain virus replication. Shown here, as an example, is a focus of woodchuck hepatitis virus (WHV) core antigen-negative hepatocytes in the liver of a woodchuck with chronic WHV infection. View this paper
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Articles (213)

  • Article
  • Open Access
4 Citations
3,445 Views
10 Pages

Radioligand Assay-Based Detection of Antibodies against SARS-CoV-2 in Hospital Workers Treating Patients with Severe COVID-19 in Japan

  • Hidenori Matsunaga,
  • Akiko Makino,
  • Yasuhiro Kato,
  • Teruaki Murakami,
  • Yuta Yamaguchi,
  • Atsushi Kumanogoh,
  • Yuichiro Oba,
  • Satoshi Fujimi,
  • Tomoyuki Honda and
  • Keizo Tomonaga

23 February 2021

This study aimed to clarify whether infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is prevalent among the staff of a hospital providing treatment to patients with severe coronavirus disease 2019 (COVID-19) using radioligand...

  • Editorial
  • Open Access
4 Citations
2,853 Views
2 Pages

Erasing the Invisible Line to Empower the Pandemic Response

  • Nicola Decaro,
  • Alessio Lorusso and
  • Ilaria Capua

23 February 2021

A challenging debate has arisen on the role of veterinary expertise in facing the SARS-CoV-2 pandemic. It seems totally unreasonable that in most countries, veterinary diagnostic and tracing forces were not deployed at the start to perform strategic...

  • Article
  • Open Access
20 Citations
4,723 Views
20 Pages

Dengue Virus Serotype 2 Intrahost Diversity in Patients with Different Clinical Outcomes

  • Maria Celeste Torres,
  • Marcos Cesar Lima de Mendonça,
  • Cintia Damasceno dos Santos Rodrigues,
  • Vagner Fonseca,
  • Mario Sergio Ribeiro,
  • Ana Paula Brandão,
  • Rivaldo Venâncio da Cunha,
  • Ana Isabel Dias,
  • Lucy Santos Vilas Boas and
  • Alvina Clara Felix
  • + 5 authors

23 February 2021

Intrahost genetic diversity is thought to facilitate arbovirus adaptation to changing environments and hosts, and it might also be linked to viral pathogenesis. Dengue virus serotype 2 (DENV-2) has circulated in Brazil since 1990 and is associated wi...

  • Review
  • Open Access
79 Citations
11,352 Views
12 Pages

23 February 2021

Mushrooms are used in their natural form as a food supplement and food additive. In addition, several bioactive compounds beneficial for human health have been derived from mushrooms. Among them, polysaccharides, carbohydrate-binding protein, peptide...

  • Article
  • Open Access
20 Citations
3,363 Views
11 Pages

BK Polyomavirus Micro-RNAs: Time Course and Clinical Relevance in Kidney Transplant Recipients

  • Baptiste Demey,
  • Véronique Descamps,
  • Claire Presne,
  • Francois Helle,
  • Catherine Francois,
  • Gilles Duverlie,
  • Sandrine Castelain and
  • Etienne Brochot

23 February 2021

Background: Kidney transplant recipients (KTRs) are exposed to a high risk of BK polyomavirus (BKPyV) replication, which in turn may lead to graft loss. Although the microRNAs (miRNAs) bkv-miR-B1-3p and bkv-miR-B1-5p are produced during the viral cyc...

  • Article
  • Open Access
27 Citations
7,609 Views
17 Pages

Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies

  • Harrison C. Bergeron,
  • Jackelyn Murray,
  • Ana M. Nuñez Castrejon,
  • Rebecca M. DuBois and
  • Ralph A. Tripp

23 February 2021

Respiratory syncytial virus (RSV) infection can cause bronchiolitis, pneumonia, morbidity, and some mortality, primarily in infants and the elderly, for which no vaccine is available. The RSV attachment (G) protein contains a central conserved domain...

  • Review
  • Open Access
49 Citations
8,091 Views
30 Pages

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure

  • Ruben J. G. Hulswit,
  • Guido C. Paesen,
  • Thomas A. Bowden and
  • Xiaohong Shi

23 February 2021

The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form capsomeric projections or spikes on the virion surface and play a crucial role i...

  • Article
  • Open Access
99 Citations
7,947 Views
11 Pages

Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro

  • Sébastien Pasquereau,
  • Zeina Nehme,
  • Sandy Haidar Ahmad,
  • Fadoua Daouad,
  • Jeanne Van Assche,
  • Clémentine Wallet,
  • Christian Schwartz,
  • Olivier Rohr,
  • Stéphanie Morot-Bizot and
  • Georges Herbein

23 February 2021

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China at the end of 2019 causing a large global outbreak. As treatments are of the utmost importance, drug repurposing embodies a rich and rapid drug discov...

  • Article
  • Open Access
20 Citations
4,370 Views
18 Pages

Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy

  • Valeria Morante,
  • Martina Borghi,
  • Iole Farina,
  • Zuleika Michelini,
  • Felicia Grasso,
  • Alessandra Gallinaro,
  • Serena Cecchetti,
  • Antonio Di Virgilio,
  • Andrea Canitano and
  • Maria Franca Pirillo
  • + 3 authors

23 February 2021

Integrase-defective lentiviral vectors (IDLVs) have been used as a safe and efficient delivery system in several immunization protocols in murine and non-human primate preclinical models as well as in recent clinical trials. In this work, we validate...

  • Article
  • Open Access
9 Citations
4,372 Views
11 Pages

Examination of Staphylococcus aureus Prophages Circulating in Egypt

  • Adriana Ene,
  • Taylor Miller-Ensminger,
  • Carine R. Mores,
  • Silvia Giannattasio-Ferraz,
  • Alan J. Wolfe,
  • Alaa Abouelfetouh and
  • Catherine Putonti

22 February 2021

Staphylococcus aureus infections are of growing concern given the increased incidence of antibiotic resistant strains. Egypt, like several other countries, has seen alarming increases in methicillin-resistant S. aureus (MRSA) infections. This species...

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Viruses - ISSN 1999-4915