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Volume 13
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10.3390/v13020333
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Article

Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes

by
Minchao Li
1,2,†,
Jinfeng Zeng
1,2,†,
Ruiting Li
1,2,
Ziyu Wen
1,2,
Yanhui Cai
3,
Jeffrey Wallin
3,
Yuelong Shu
1,2,
Xiangjun Du
1,2,* and
Caijun Sun
1,2,*
1
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
2
Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 514400, China
3
Gilead Sciences, Inc. 333 Lakeside Dr, Foster City, CA 94404, USA
*
Authors to whom correspondence should be addressed.
†
These authors contribute equally to this work.
Viruses 2021, 13(2), 333; https://doi.org/10.3390/v13020333
Submission received: 12 January 2021 / Revised: 13 February 2021 / Accepted: 19 February 2021 / Published: 21 February 2021
(This article belongs to the Section SARS-CoV-2 and COVID-19)
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Abstract

With the rapid global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, a safe and effective vaccine against human coronaviruses (HCoVs) is believed to be a top priority in the field of public health. Due to the frequent outbreaks of different HCoVs, the development of a pan-HCoVs vaccine is of great value to biomedical science. The antigen design is a key prerequisite for vaccine efficacy, and we therefore developed a novel antigen with broad coverage based on the genetic algorithm of mosaic strategy. The designed antigen has a potentially broad coverage of conserved cytotoxic T lymphocyte (CTL) epitopes to the greatest extent, including the existing epitopes from all reported HCoV sequences (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2). This novel antigen is expected to induce strong CTL responses with broad coverage by targeting conserved epitopes against multiple coronaviruses.
Keywords: coronavirus; pan-vaccine; antigen design; conserved epitopes coronavirus; pan-vaccine; antigen design; conserved epitopes

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MDPI and ACS Style

Li, M.; Zeng, J.; Li, R.; Wen, Z.; Cai, Y.; Wallin, J.; Shu, Y.; Du, X.; Sun, C. Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes. Viruses 2021, 13, 333. https://doi.org/10.3390/v13020333

AMA Style

Li M, Zeng J, Li R, Wen Z, Cai Y, Wallin J, Shu Y, Du X, Sun C. Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes. Viruses. 2021; 13(2):333. https://doi.org/10.3390/v13020333

Chicago/Turabian Style

Li, Minchao, Jinfeng Zeng, Ruiting Li, Ziyu Wen, Yanhui Cai, Jeffrey Wallin, Yuelong Shu, Xiangjun Du, and Caijun Sun. 2021. "Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes" Viruses 13, no. 2: 333. https://doi.org/10.3390/v13020333

APA Style

Li, M., Zeng, J., Li, R., Wen, Z., Cai, Y., Wallin, J., Shu, Y., Du, X., & Sun, C. (2021). Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes. Viruses, 13(2), 333. https://doi.org/10.3390/v13020333

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