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Viruses, Volume 13, Issue 3

March 2021 - 177 articles

Cover Story: Cell–cell fusion induced by SARS-CoV-2 infection: SARS-CoV-2 utilizes host type II transmembrane serine protease (TTSP) to cleave and activate the virus spike protein to facilitate cellular entry. Although TMPRSS2 is well characterized, the role of other TTSPs on the infection of SARS-CoV-2 remains to be elucidated. Here, we demonstrated that exogenous expression of TMPRSS11D and TMPRSS13 enhanced cellular entry and subsequent replication of SARS-CoV-2, which may have implications for cell and tissue tropism. View this paper
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Articles (177)

  • Review
  • Open Access
4 Citations
5,094 Views
18 Pages

23 March 2021

SUMOylation is a highly dynamic ubiquitin-like post-translational modification that is essential for cells to respond to and resolve various genotoxic and proteotoxic stresses. Virus infections also constitute a considerable stress scenario for cells...

  • Case Report
  • Open Access
33 Citations
5,181 Views
10 Pages

SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma

  • Julia Klaus,
  • Carlo Palizzotto,
  • Eric Zini,
  • Marina L. Meli,
  • Chiara Leo,
  • Herman Egberink,
  • Shan Zhao and
  • Regina Hofmann-Lehmann

23 March 2021

Since the coronavirus disease (COVID-19) pandemic was first identified in early 2020, rare cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in pet cats have been reported worldwide. Some reports of cats with SARS-CoV-2...

  • Article
  • Open Access
18 Citations
5,928 Views
17 Pages

Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model

  • Luca M. Zaeck,
  • David Scheibner,
  • Julia Sehl,
  • Martin Müller,
  • Donata Hoffmann,
  • Martin Beer,
  • Elsayed M. Abdelwhab,
  • Thomas C. Mettenleiter,
  • Angele Breithaupt and
  • Stefan Finke

23 March 2021

The visualization of viral pathogens in infected tissues is an invaluable tool to understand spatial virus distribution, localization, and cell tropism in vivo. Commonly, virus-infected tissues are analyzed using conventional immunohistochemistry in...

  • Article
  • Open Access
14 Citations
4,222 Views
14 Pages

23 March 2021

Effective broad-spectrum antiviral treatments are in dire need as disinfectants and therapeutic alternatives. One such method of disinfection is photodynamic inactivation, which involves the production of reactive oxygen species from dissolved oxygen...

  • Communication
  • Open Access
2 Citations
4,872 Views
11 Pages

23 March 2021

The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new disinfection systems. Evidence has proven that airborne transmission is an important route of spreading for this virus. Therefore, this sh...

  • Article
  • Open Access
26 Citations
5,036 Views
11 Pages

Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing

  • Prabhat Pratap Singh Tomar,
  • Miriam Krugliak and
  • Isaiah T. Arkin

23 March 2021

The etiological agent of the COVID-19 pandemic is SARS-CoV-2. As a member of the Coronaviridae, the enveloped pathogen has several membrane proteins, of which two, E and 3a, were suggested to function as ion channels. In an effort to increase our tre...

  • Article
  • Open Access
24 Citations
5,996 Views
21 Pages

Functional Analysis of the Fusion and Attachment Glycoproteins of Mojiang Henipavirus

  • Sofia Cheliout Da Silva,
  • Lianying Yan,
  • Ha V. Dang,
  • Kai Xu,
  • Jonathan H. Epstein,
  • David Veesler and
  • Christopher C. Broder

22 March 2021

Mojiang virus (MojV) is the first henipavirus identified in a rodent and known only by sequence data, whereas all other henipaviruses have been isolated from bats (Hendra virus, Nipah virus, Cedar virus) or discovered by sequence data from material o...

  • Review
  • Open Access
30 Citations
6,313 Views
21 Pages

Host Components That Modulate the Disease Caused by hMPV

  • Nicolás M. S. Gálvez,
  • Catalina A. Andrade,
  • Gaspar A. Pacheco,
  • Jorge A. Soto,
  • Vicente Stranger,
  • Thomas Rivera,
  • Abel E. Vásquez and
  • Alexis M. Kalergis

22 March 2021

Human metapneumovirus (hMPV) is one of the main pathogens responsible for acute respiratory infections in children up to 5 years of age, contributing substantially to health burden. The worldwide economic and social impact of this virus is significan...

  • Review
  • Open Access
31 Citations
7,639 Views
22 Pages

Hepatitis C Viral Replication Complex

  • Hui-Chun Li,
  • Chee-Hing Yang and
  • Shih-Yen Lo

22 March 2021

The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic RNA replication occurs in the replication organelles (RO) and is t...

  • Article
  • Open Access
14 Citations
3,941 Views
15 Pages

Selective Interaction of Sugarcane eIF4E with VPgs from Sugarcane Mosaic Pathogens

  • Zongtao Yang,
  • Meng Dong,
  • Guangyuan Cheng,
  • Shuxian Liu,
  • Hai Zhang,
  • Heyang Shang,
  • Yingshuan Zhou,
  • Guoqiang Huang,
  • Muqing Zhang and
  • Fengji Wang
  • + 1 author

22 March 2021

Eukaryotic translation initiation factor 4E (eIF4E) plays a key role in the infection of potyviruses in susceptible plants by interacting with viral genome-linked protein (VPg). Sugarcane (Saccharum spp.) production is threatened by mosaic disease ca...

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Viruses - ISSN 1999-4915