Special Issue "BK Virus and Transplantation"
Deadline for manuscript submissions: closed (31 January 2021).
Interests: Polyomavirus and Polyomavirus-associated diseases; Polyomavirus reactivation under immunosuppression or during immunomodulatory therapy; Polyomavirus involved in cancer transformation; development of in vitro models
It is well known that BK virus (BKV)-associated diseases in transplant recipients are an emerging issue and that kidney transplant recipients (KTRs) comprise the patient population that most frequently experiences complications of BKV reactivation. A proportion of these recipients can develop BKV-associated nephropathy (BKVAN), which is associated with a significant risk of allograft loss. In addition, hemorrhagic cystitis (HC) is a well-recognized BKV-associated complication in hematopoietic stem cell transplant (HSCT) recipients.
In this Special Issue of Viruses, we want to explore some aspects related to BKV-associated diseases in transplant recipients, since they are still unclear, as follows:
- the mechanism of viral persistence and the conditions that lead to viral reactivation upon immunosuppression;
- the role that innate immune mediators play in controlling BKV infection;
- a better understanding of viral subtypes and subgroups and their causative roles in the development of clinical syndromes and nephropathy;
- the study of new antiviral agents for BKV infection, since the mainstay of managing reactivation is reduction of immunosuppression;
- the development of immune-based therapies to combat BKV and BKV-associated complications;
- the development of improved diagnostic tools and clinical management strategies, useful for tracing infection trails in epidemiologic investigations.
Prof. Valeria Pietropaolo
Manuscript Submission Information
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- BK virus
- BK virus strains
- immunosuppressive therapy
- kidney transplant
- haemorrhagic cystitis
- noncoding control region (NCCR)