Next Article in Journal
Aerosolized Exposure to H5N1 Influenza Virus Causes Less Severe Disease Than Infection via Combined Intrabronchial, Oral, and Nasal Inoculation in Cynomolgus Macaques
Next Article in Special Issue
Liver-Derived Cell Transfection Model Efficacy for HBV Genotype B Replication/Transcription Is Determined by Complex Host Transcription Factor Network
Previous Article in Journal
Transcriptome Analysis of Responses to Dengue Virus 2 Infection in Aedes albopictus (Skuse) C6/36 Cells
Previous Article in Special Issue
Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability
Open AccessReview

Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1

1
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico
2
High Speciality Cardiology Unit “Korazón”, Puerta de Hierro Hospital, Tepic 63173, Nayarit, Mexico
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Angela L. Rasmussen and Juliet Morrison
Viruses 2021, 13(2), 344; https://doi.org/10.3390/v13020344
Received: 23 December 2020 / Revised: 7 February 2021 / Accepted: 18 February 2021 / Published: 22 February 2021
(This article belongs to the Special Issue Host Factors in Viral Infections)
Influenza A virus (IAV) is the most common infectious agent in humans, and infects approximately 10–20% of the world’s population, resulting in 3–5 million hospitalizations per year. A scientific literature search was performed using the PubMed database and the Medical Subject Headings (MeSH) “Influenza A H1N1” and “Genetic susceptibility”. Due to the amount of information and evidence about genetic susceptibility generated from the studies carried out in the last influenza A H1N1 pandemic, studies published between January 2009 to May 2020 were considered; 119 papers were found. Several pathways are involved in the host defense against IAV infection (innate immune response, pro-inflammatory cytokines, chemokines, complement activation, and HLA molecules participating in viral antigen presentation). On the other hand, single nucleotide polymorphisms (SNPs) are a type of variation involving the change of a single base pair that can mean that encoded proteins do not carry out their functions properly, allowing higher viral replication and abnormal host response to infection, such as a cytokine storm. Some of the most studied SNPs associated with IAV infection genetic susceptibility are located in the FCGR2A, C1QBP, CD55, and RPAIN genes, affecting host immune responses through abnormal complement activation. Also, SNPs in IFITM3 (which participates in endosomes and lysosomes fusion) represent some of the most critical polymorphisms associated with IAV infection, suggesting an ineffective virus clearance. Regarding inflammatory response genes, single nucleotide variants in IL1B, TNF, LTA IL17A, IL8, IL6, IRAK2, PIK3CG, and HLA complex are associated with altered phenotype in pro-inflammatory molecules, participating in IAV infection and the severest form of the disease. View Full-Text
Keywords: influenza; inflammation; genetic susceptibility; polymorphisms; cytokine storm influenza; inflammation; genetic susceptibility; polymorphisms; cytokine storm
Show Figures

Figure 1

MDPI and ACS Style

Pérez-Rubio, G.; Ponce-Gallegos, M.A.; Domínguez-Mazzocco, B.A.; Ponce-Gallegos, J.; García-Ramírez, R.A.; Falfán-Valencia, R. Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1. Viruses 2021, 13, 344. https://doi.org/10.3390/v13020344

AMA Style

Pérez-Rubio G, Ponce-Gallegos MA, Domínguez-Mazzocco BA, Ponce-Gallegos J, García-Ramírez RA, Falfán-Valencia R. Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1. Viruses. 2021; 13(2):344. https://doi.org/10.3390/v13020344

Chicago/Turabian Style

Pérez-Rubio, Gloria; Ponce-Gallegos, Marco A.; Domínguez-Mazzocco, Bruno A.; Ponce-Gallegos, Jaime; García-Ramírez, Román A.; Falfán-Valencia, Ramcés. 2021. "Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1" Viruses 13, no. 2: 344. https://doi.org/10.3390/v13020344

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop