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Open AccessReview

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure

1
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
2
MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G61 1QH, UK
*
Authors to whom correspondence should be addressed.
Academic Editors: Esther Schnettler and Benjamin Brennan
Viruses 2021, 13(2), 353; https://doi.org/10.3390/v13020353
Received: 15 January 2021 / Revised: 13 February 2021 / Accepted: 15 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Bunyavirus 2020)
The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form capsomeric projections or spikes on the virion surface and play a crucial role in virus entry, assembly, morphogenesis. Bunyavirus glycoproteins are encoded by a single RNA segment as a polyprotein precursor that is co- and post-translationally cleaved by host cell enzymes to yield two mature glycoproteins, Gn and Gc (or GP1 and GP2 in arenaviruses). These glycoproteins undergo extensive N-linked glycosylation and despite their cleavage, remain associated to the virion to form an integral transmembrane glycoprotein complex. This review summarizes recent advances in our understanding of the molecular biology of bunyavirus glycoproteins, including their processing, structure, and known interactions with host factors that facilitate cell entry. View Full-Text
Keywords: Bunyavirales; bunyavirus; glycoproteins; glycoprotein precursor processing; genomic coding strategy; receptor binding; protein structure Bunyavirales; bunyavirus; glycoproteins; glycoprotein precursor processing; genomic coding strategy; receptor binding; protein structure
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MDPI and ACS Style

Hulswit, R.J.G.; Paesen, G.C.; Bowden, T.A.; Shi, X. Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure. Viruses 2021, 13, 353. https://doi.org/10.3390/v13020353

AMA Style

Hulswit RJG, Paesen GC, Bowden TA, Shi X. Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure. Viruses. 2021; 13(2):353. https://doi.org/10.3390/v13020353

Chicago/Turabian Style

Hulswit, Ruben J.G.; Paesen, Guido C.; Bowden, Thomas A.; Shi, Xiaohong. 2021. "Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure" Viruses 13, no. 2: 353. https://doi.org/10.3390/v13020353

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