Special Issue "Mechanisms of Viral Persistence"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 15 January 2021.

Special Issue Editors

Dr. Mary Kearney
Guest Editor
Center for Cancer Research, National Cancer Institute, Frederick, USA
Interests: HIV translational research; HIV persistence; intra-patient viral genetics; single cell viral genetics and expression; clonal expansion of HIV infected cells
Dr. Bill Sugden
Guest Editor
McArdle Laboratory for Cancer Research, Madison, USA
Interests: The mechanisms by which Epstein-Barr Virus and Kaposi’s Sarcoma Herpesvirus contribute to transformation of cells in vitro and tumor formation in vivo

Special Issue Information

Dear Colleagues,

Viruses of many families can persist in people after an initial phase of infection in chronically lytic and/or latent forms. Viral persistence may be maintained for weeks, months, years, or even for a person’s lifetime. The mechanisms that promote viral persistence in vivo vary across different pathogens and can be imposed by both the virus and the host. Understanding these mechanisms is key to revealing potential targets to be exploited in future strategies to cure these infections. In this Special Issue, we provide original and review articles describing how viruses including HPV, EBV, KSHV, HCV, HIV, and HTLV maintain themselves in proliferating cells and escape immune targeting and elimination. These viruses persist by downregulating host factors, modifying host or viral genetics, and using special mechanisms to maintain latency by affecting host cell survival and proliferation. These articles illustrate the breadth and complexity of the functions used by viral pathogens to persist in their human hosts.

Dr. Mary Kearney
Dr. Bill Sugden
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • persistence
  • latency
  • immune escape
  • transcriptional modification or silencing
  • eradication
  • remission
  • genome replication
  • genome partitioning

Published Papers

This special issue is now open for submission.
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