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Current Oncology, Volume 30, Issue 12

December 2023 - 41 articles

Cover Story: Epithelial ovarian cancer is a heterogeneous group of malignancies. While BRCA variants elevate the risk of ovarian cancer, most cases occur in individuals without any known genetic variants, necessitating prevention strategies for people without known high-risk genetic variants. Opportunistic salpingectomy, removing fallopian tubes during planned pelvic surgery, is an emerging primary prevention strategy. Evidence of effectiveness has emerged in patients who underwent opportunistic salpingectomy for cancer prevention. This, coupled with an increased understanding of precursor lesions, has turned attention towards broadening opportunities for salpingectomy, as well as offering fallopian tube removal to people at higher-than-average lifetime risk for ovarian cancer despite not having a known genetic mutation that increases their risk. View this paper
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Articles (41)

  • Article
  • Open Access
1 Citations
1,885 Views
13 Pages

Anastomosis Complications after Bronchoplasty: Incidence, Risk Factors, and Treatment Options Reported by a Referral Cancer Center

  • Lara Girelli,
  • Luca Bertolaccini,
  • Monica Casiraghi,
  • Francesco Petrella,
  • Domenico Galetta,
  • Antonio Mazzella,
  • Stefano Donghi,
  • Giorgio Lo Iacono,
  • Andrea Cara and
  • Juliana Guarize
  • + 1 author

12 December 2023

Background: Sleeve lobectomy with bronchoplasty is a safe surgical technique for the management of lung cancer and endobronchial localization of extrapulmonary cancers. However, anastomotic complications can occur, and treatment strategies are not st...

  • Guidelines
  • Open Access
6 Citations
5,572 Views
27 Pages

The Clinical Utility of FLT3 Mutation Testing in Acute Leukemia: A Canadian Consensus

  • Julie Bergeron,
  • Jose-Mario Capo-Chichi,
  • Hubert Tsui,
  • Etienne Mahe,
  • Philip Berardi,
  • Mark D. Minden,
  • Joseph M. Brandwein and
  • Andre C. Schuh

12 December 2023

FMS-like tyrosine kinase 3 (FLT3) mutations are detected in approximately 20–30% of patients with acute myeloid leukemia (AML), with the presence of a FLT3 internal tandem duplication (FLT3-ITD) mutation being associated with an inferior outcom...

  • Article
  • Open Access
7 Citations
2,971 Views
12 Pages

Durvalumab-Associated Pneumonitis in Patients with Locally Advanced Non-Small Cell Lung Cancer: A Real-World Population Study

  • Chloe Ahryung Lim,
  • Sunita Ghosh,
  • Hali Morrison,
  • Daniel Meyers,
  • Igor Stukalin,
  • Marc Kerba,
  • Desiree Hao and
  • Aliyah Pabani

9 December 2023

The PACIFIC trial led to a new standard of care for patients with locally advanced lung cancer, but real-world practice has demonstrated that immune checkpoint inhibitor (ICI) pneumonitis can lead to significant clinical complications. This study aim...

  • Article
  • Open Access
2 Citations
1,936 Views
11 Pages

8 December 2023

Background: Nodal failure is a major failure pattern for patients with FIGO IIIC cervical cancer, which is further associated with worse survival. This study was designed to investigate risk factors for nodal failure in FIGO IIIC cervical cancer pati...

  • Guidelines
  • Open Access
6 Citations
5,211 Views
22 Pages

Canadian Consensus Recommendations for the Management of Operable Stage II/III Non-Small-Cell Lung Cancer: Results of a Modified Delphi Process

  • James Tankel,
  • Jonathan Spicer,
  • Quincy Chu,
  • Pierre Olivier Fiset,
  • Biniam Kidane,
  • Natasha B. Leighl,
  • Philippe Joubert,
  • Donna Maziak,
  • David Palma and
  • Anna McGuire
  • + 4 authors

6 December 2023

The treatment paradigm for patients with stage II/III non-small-cell lung cancer (NSCLC) is rapidly evolving. We performed a modified Delphi process culminating at the Early-stage Lung cancer International eXpert Retreat (ELIXR23) meeting held in Mon...

  • Article
  • Open Access
12 Citations
3,764 Views
12 Pages

Factors Predictive of Positive Lymph Nodes for Breast Cancer

  • Kelly M. Elleson,
  • Katherine Englander,
  • Julia Gallagher,
  • Neha Chintapally,
  • Weihong Sun,
  • Junmin Whiting,
  • Melissa Mallory,
  • John Kiluk,
  • Susan Hoover and
  • Nazanin Khakpour
  • + 3 authors

6 December 2023

Background: Axillary node status is an important prognostic factor in breast cancer. The primary aim was to evaluate tumor size and other characteristics relative to axillary disease. Materials and Methods: Single institution retrospective chart revi...

  • Article
  • Open Access
13 Citations
2,886 Views
15 Pages

Head and Neck Cancer: A Study on the Complex Relationship between QoL and Swallowing Function

  • Daniel Strüder,
  • Johanna Ebert,
  • Friederike Kalle,
  • Sebastian P. Schraven,
  • Lennart Eichhorst,
  • Robert Mlynski and
  • Wilma Großmann

6 December 2023

Head and neck squamous cell carcinoma (HNSCC) is linked to significant morbidity, adversely affecting survival and functional capacity. Post-treatment challenges such as pain, dysphonia, and dysphagia are common, prompting increased attention in surv...

  • Article
  • Open Access
1 Citations
3,304 Views
11 Pages

Trends in Selective Internal Radiation Therapy (SIRT) for Treating Hepatocellular Carcinoma, Cholangiocarcinoma, and Liver Metastasis: A Total Population Analysis from 2006 to 2021 in Germany

  • Smita George Thoduka,
  • Luka Flegar,
  • Christer Groeben,
  • Johannes Huber,
  • Nicole Eisenmenger,
  • Tobias Paulus,
  • Katharina Vogt,
  • Markus Luster and
  • Nasreddin Abolmaali

5 December 2023

The aim of this study was to investigate trends in selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC), cholangiocarcinoma (CCC), and liver metastasis in Germany. We analyzed the nationwide German hospital billing database...

  • Systematic Review
  • Open Access
3 Citations
2,733 Views
14 Pages

4 December 2023

Preclinical and clinical studies have suggested potential synergies of combining poly (ADP-ribose) polymerase (PARP) inhibitors and novel hormonal therapies (NHT) for patients with metastatic castration-resistant prostate cancer (mCRPC). We systemati...

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Curr. Oncol. - ISSN 1718-7729