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Current Oncology, Volume 28, Issue 6

December 2021 - 97 articles

Cover Story: Germline mutations in BRCA genes are a frequent molecular event in the most lethal type of epithelial ovarian cancer, high-grade serous carcinoma (HGSC). To date, little emphasis has been placed on the effects of cancer-causing BRCA1/2 mutations located in different domains of molecules on HGSC prognosis. Therefore, we investigated the correlation between the mutation location within BRCA genes and clinical outcome. After multivariate analysis of the 51-patient cohort, no significant association between the location or type of BRCA1/2 mutation and the PFS or OS was identified. Notably, significant PFS differences between carriers of identical mutations were detected. These outcome dissimilarities reinforce that the clinical course of HGSC is not solely determined by mutation location, suggesting a potential effect of other genetic abnormalities and risk factors. View this paper
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Articles (97)

  • Case Report
  • Open Access
11 Citations
4,386 Views
10 Pages

Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab

  • David Pisani,
  • Jean Calleja-Agius,
  • Riccardo Di Fiore,
  • John J. O’Leary,
  • James P. Beirne,
  • Sharon A. O’Toole,
  • Ana Felix and
  • Ian Said-Huntingford

13 December 2021

Epithelioid trophoblastic tumours are rare neoplasms showing differentiation towards the chorion leave-type intermediate cytotrophoblast, with only a handful of cases being reported in the literature. These tumours are slow-growing and are typically...

  • Review
  • Open Access
170 Citations
14,639 Views
28 Pages

Pathological Features and Prognostication in Colorectal Cancer

  • Kabytto Chen,
  • Geoffrey Collins,
  • Henry Wang and
  • James Wei Tatt Toh

13 December 2021

The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) TNM staging classifications. However, clinically, there a...

  • Case Report
  • Open Access
6 Citations
3,321 Views
9 Pages

Carcinosarcoma, a Rare Malignant Neoplasm of the Pancreas

  • Jaffar Khan,
  • Liang Cheng,
  • Michael G. House and
  • Shunhua Guo

12 December 2021

Carcinosarcoma of the pancreas is a rare entity with poor prognosis. Here, we report a case of pancreatic carcinosarcoma in a 68-year-old male patient who underwent a pancreatoduodenectomy for a unilocular cystic mass in the head of the pancreas. His...

  • Article
  • Open Access
11 Citations
4,788 Views
14 Pages

A Retrospective Comparative Analysis of Outcomes and Prognostic Factors in Adult and Pediatric Patients with Osteosarcoma

  • Stefano Testa,
  • Benjamin D. Hu,
  • Natalie L. Saadeh,
  • Allison Pribnow,
  • Sheri L. Spunt,
  • Gregory W. Charville,
  • Nam Q. Bui and
  • Kristen N. Ganjoo

12 December 2021

Osteosarcoma is the most common primary bone malignancy in both children and adults. Despite introduction of intensive multimodal treatment with chemotherapy and surgery, outcomes are still poor, especially for patients with metastatic disease and ad...

  • Brief Report
  • Open Access
31 Citations
4,725 Views
14 Pages

Feasibility on the Use of Radiomics Features of 11[C]-MET PET/CT in Central Nervous System Tumours: Preliminary Results on Potential Grading Discrimination Using a Machine Learning Model

  • Giorgio Russo,
  • Alessandro Stefano,
  • Pierpaolo Alongi,
  • Albert Comelli,
  • Barbara Catalfamo,
  • Cristina Mantarro,
  • Costanza Longo,
  • Roberto Altieri,
  • Francesco Certo and
  • Sebastiano Cosentino
  • + 4 authors

12 December 2021

Background/Aim: Nowadays, Machine Learning (ML) algorithms have demonstrated remarkable progress in image-recognition tasks and could be useful for the new concept of precision medicine in order to help physicians in the choice of therapeutic strateg...

  • Article
  • Open Access
13 Citations
4,693 Views
17 Pages

11 December 2021

BACKGROUND AND OBJECTIVES: Molecular genetic testing using tissue biopsies can be challenging for patients due to unfavorable tumor sites, the invasive nature of a tissue biopsy, and the added time of booking a repeat biopsy (re-biopsy). Centers in C...

  • Article
  • Open Access
3 Citations
3,732 Views
12 Pages

Real-World Data on Treatment Management and Outcomes of Patients with Newly Diagnosed Advanced Epithelial Ovarian Cancer in Greece (The EpOCa Study)

  • Michalis Liontos,
  • Eleni Timotheadou,
  • Emmanuel I. Papadopoulos,
  • Zafeiris Zafeiriou,
  • Dimitra Ioanna Lampropoulou,
  • Gerasimos Aravantinos,
  • Dimitrios Mavroudis,
  • Christos Christodoulou,
  • Adamantia Nikolaidi and
  • Alvertos Somarakis
  • + 3 authors

10 December 2021

New treatment modalities have been recently introduced in the management of ovarian cancer (OC). Herein, we sought to investigate their implementation in routine clinical practice and examine the real-world management of OC in Greece. EpOCa was a non...

  • Article
  • Open Access
4 Citations
3,682 Views
15 Pages

The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS

  • Noemi Daradics,
  • Pim B. Olthof,
  • Andras Budai,
  • Michal Heger,
  • Thomas M. van Gulik,
  • Andras Fulop and
  • Attila Szijarto

9 December 2021

Background: the role of bile acid (BA)-induced farnesoid X receptor (Fxr) signaling in liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was investigated in a rat model. Methods: Male Wis...

  • Article
  • Open Access
4 Citations
3,229 Views
11 Pages

Salvage Surgical Resection after Linac-Based Stereotactic Radiosurgery for Newly Diagnosed Brain Metastasis

  • Ryosuke Matsuda,
  • Takayuki Morimoto,
  • Tetsuro Tamamoto,
  • Nobuyoshi Inooka,
  • Tomoko Ochi,
  • Toshiteru Miyasaka,
  • Shigeto Hontsu,
  • Kaori Yamaki,
  • Sachiko Miura and
  • Yasuhiro Takeshima
  • + 8 authors

9 December 2021

Background: This study aimed to assess the clinical outcomes of salvage surgical resection (SSR) after stereotactic radiosurgery and fractionated stereotactic radiotherapy (SRS/fSRT) for newly diagnosed brain metastasis. Methods: Between November 200...

  • Article
  • Open Access
12 Citations
3,559 Views
12 Pages

Experiences and Perceptions of Older Adults with Lower-Risk Hormone Receptor-Positive Breast Cancer about Adjuvant Radiotherapy and Endocrine Therapy: A Patient Survey

  • Marie-France Savard,
  • Mashari Jemaan Alzahrani,
  • Deanna Saunders,
  • Lynn Chang,
  • Angel Arnaout,
  • Terry L. Ng,
  • Muriel Brackstone,
  • Lisa Vandermeer,
  • Tina Hsu and
  • Ari Ali Awan
  • + 3 authors

8 December 2021

Older patients with lower-risk hormone receptor-positive (HR+) breast cancer are frequently offered both radiotherapy (RT) and endocrine therapy (ET) after breast-conserving surgery (BCS). A survey was performed to assess older patients’ experi...

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Curr. Oncol. - ISSN 1718-7729