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Marine Drugs, Volume 20, Issue 6

June 2022 - 67 articles

Cover Story: Jellyfish are considered a nuisance for their negative effects on human health activities at sea. However, they are emerging as an alternative source of high-value compounds. In this study, we highlight that the methanolic extracts and enriched fractions from the scyphomedusa Cotylorhiza tuberculata and the cubomedusa Caryddea marsupialis reduced cell viability of specific human tumor cell lines in a dose-dependent manner. The mechanism behind the antiproliferative activity appears to be the reduction in gene expression related to apoptosis inhibition in melanoma-treated cells, which makes jellyfish a potential new source of antiproliferative drugs to be exploited in the future. View this paper
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Articles (67)

  • Review
  • Open Access
16 Citations
3,941 Views
21 Pages

Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism

  • Sijin Hang,
  • Hui Chen,
  • Wenhui Wu,
  • Shiyi Wang,
  • Yiwen Fang,
  • Ruilong Sheng,
  • Qidong Tu and
  • Ruihua Guo

20 June 2022

Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse bioactivities such as thrombolysis, anti-inflammatory and anti-oxidative propertie...

  • Review
  • Open Access
29 Citations
7,248 Views
26 Pages

Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents

  • Mengjing Cong,
  • Xiaoyan Pang,
  • Kai Zhao,
  • Yue Song,
  • Yonghong Liu and
  • Junfeng Wang

19 June 2022

The deep sea has been proven to be a great treasure for structurally unique and biologically active natural products in the last two decades. Cold seeps and hydrothermal vents, as typical representatives of deep-sea extreme environments, have attract...

  • Review
  • Open Access
43 Citations
5,854 Views
15 Pages

Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions

  • Biswajita Pradhan,
  • Rabindra Nayak,
  • Prajna Paramita Bhuyan,
  • Srimanta Patra,
  • Chhandashree Behera,
  • Sthitaprajna Sahoo,
  • Jang-Seu Ki,
  • Alessandra Quarta,
  • Andrea Ragusa and
  • Mrutyunjay Jena

18 June 2022

The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It...

  • Article
  • Open Access
31 Citations
6,202 Views
15 Pages

Injectable Thermosensitive Chitosan-Collagen Hydrogel as A Delivery System for Marine Polysaccharide Fucoidan

  • Julia Ohmes,
  • Lena Marie Saure,
  • Fabian Schütt,
  • Marie Trenkel,
  • Andreas Seekamp,
  • Regina Scherließ,
  • Rainer Adelung and
  • Sabine Fuchs

18 June 2022

Fucoidans, sulfated polysaccharides from brown algae, possess multiple bioactivities in regard to osteogenesis, angiogenesis, and inflammation, all representing key molecular processes for successful bone regeneration. To utilize fucoidans in regener...

  • Article
  • Open Access
4 Citations
4,196 Views
17 Pages

Preparation of Ion2+-COS/SA Multifunctional Gel Films for Skin Wound Healing by an In Situ Spray Method

  • Liqi Chen,
  • Tingting Guo,
  • Chao Shi,
  • Kun Zhang,
  • Shenghao Cui,
  • Di Zhao,
  • Faming Yang and
  • Jingdi Chen

18 June 2022

The rapid preparation of safe and efficient wound dressings that meet the needs of the entire repair process remains a major challenge for effective therapeutic wound healing. Natural, sprayable Ion2+-COS/SA multifunctional dual-network gel films cre...

  • Article
  • Open Access
10 Citations
4,135 Views
14 Pages

Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp.

  • Jinsheng Cui,
  • Eunji Kim,
  • Dong Hyun Moon,
  • Tae Ho Kim,
  • Ilnam Kang,
  • Yeonjung Lim,
  • Daniel Shin,
  • Sunghoon Hwang,
  • Young Eun Du and
  • Myoung Chong Song
  • + 6 authors

16 June 2022

Two new lipo-decapeptides, namely taeanamides A and B (1 and 2), were discovered from the Gram-positive bacterium Streptomyces sp. AMD43, which was isolated from a mudflat sample from Anmyeondo, Korea. The exact molecular masses of 1 and 2 were revea...

  • Article
  • Open Access
11 Citations
3,722 Views
14 Pages

In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2

  • Nalae Kang,
  • Seong-Yeong Heo,
  • Seon-Heui Cha,
  • Ginnae Ahn and
  • Soo-Jin Heo

16 June 2022

Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targe...

  • Review
  • Open Access
27 Citations
8,104 Views
23 Pages

Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery

  • Jessie James Limlingan Malit,
  • Hiu Yu Cherie Leung and
  • Pei-Yuan Qian

16 June 2022

Large-scale genome-mining analyses have identified an enormous number of cryptic biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products. Given the sheer number of natural product (NP) candidates, effective strategies...

  • Review
  • Open Access
54 Citations
9,655 Views
51 Pages

Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies

  • Ricardo Ribeiro,
  • Eugénia Pinto,
  • Carla Fernandes and
  • Emília Sousa

15 June 2022

Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of biolo...

  • Review
  • Open Access
47 Citations
7,234 Views
28 Pages

Applications of Chitosan in Surgical and Post-Surgical Materials

  • Fernando Notario-Pérez,
  • Araceli Martín-Illana,
  • Raúl Cazorla-Luna,
  • Roberto Ruiz-Caro and
  • María Dolores Veiga

15 June 2022

The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, c...

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Mar. Drugs - ISSN 1660-3397