Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Antimicrobial and Antiviral Agents from Marine Sources
share announcement

Antimicrobial and Antiviral Agents from Marine Sources

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 12261

Special Issue Editors

Prof. Dr. Lamiaa Shaala

E-Mail Website
Guest Editor
Suez Canal University Hospital, Suez Canal University, Ismailia 41522, Egypt
Interests: marine natural products; marine biodiscovery; invertebrates; cyanobacteria; marine microbes; structure determinations; marine alkaloids; antitumor and antibiotics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Diaa Youssef

E-Mail Website
Guest Editor
Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
Interests: marine natural products; marine toxins; harmful algal blooms; dinoflagellates; cyanobacteria; sponges; environmental metabolomics; marine chemical ecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the late Professor Ernesto Fattorusso, for his pioneering work in the area of Marine Natural Products.

The misuse and overuse of antibiotics in human and veterinary medicine and agriculture, as well as unsuitable waste management, have resulted in substantially increased antimicrobial resistance, with associated bacterial persistence. This is of major public concern since most areas of modern medicine are unthinkable without access to effective treatment with antibiotics. Furthermore, an overlooked aspect of worry with regard to the COVID-19 pandemic is secondary infections, associated with multidrug-resistant bacteria, which are observed in hospitalized patients and those with already compromised immune systems. Associated with this problem is the massive use of antibiotics as a COVID-19 (co)treatment worldwide, which is predicted to add to the ongoing emergence of antimicrobial resistance.

The discovery of antibiotics and antiviral agents represents a major focus of chemists and pharmacologists in the area of marine biodiscovery.

This Special Issue aims to incorporate original research articles on the discovery of secondary metabolites of marine origin with antimicrobial and antiviral potential and recent reviews on previously reported marine compounds with antimicrobial and/or antiviral activities, as well as diverse applications of these antimicrobial and or antiviral secondary effects in drug development, as agrochemicals, and in other applications.

Prof. Dr. Lamiaa Shaala
Prof. Dr. Diaa Youssef
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine macro- and microorganisms
  • bioassay-guided purification of hits
  • marine secondary metabolites
  • structure determination
  • antimicrobial
  • antifungal
  • antibiotics
  • antiviral
  • docking
  • quorum-sensing inhibition
  • inhibition of microbial biofilm formation
  • pharmaceutical application

Related Special Issue

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

10 pages, 1245 KiB  
Article
Pyrrole-Containing Alkaloids from a Marine-Derived Actinobacterium Streptomyces zhaozhouensis and Their Antimicrobial and Cytotoxic Activities
by Chang-Su Heo, Jong Soon Kang, Joo-Hee Kwon, Cao Van Anh and Hee Jae Shin
Mar. Drugs 2023, 21(3), 167; https://doi.org/10.3390/md21030167 - 06 Mar 2023
Cited by 4 | Viewed by 1890
Abstract
Two new alkaloids, streptopyrroles B and C (1 and 2), were discovered through a chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, Streptomyces zhaozhouensis, along with four known analogs (3–6). The structures [...] Read more.
Two new alkaloids, streptopyrroles B and C (1 and 2), were discovered through a chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, Streptomyces zhaozhouensis, along with four known analogs (3–6). The structures of the new compounds were elucidated by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR) and a comparison of their experimental data with literature values. The new compounds were evaluated for their antimicrobial activity by standard broth dilution assay, and the tested compounds showed significant activity against Gram-positive bacteria with minimum inhibitory concentration (MIC) values ranging from 0.7 to 2.9 µM, and kanamycin was used as a positive control with MIC values ranging from <0.5 to 4.1 µM. Additionally, 1, 3, and 5 were evaluated for their cytotoxicity against six tumor cell lines by sulforhodamine B (SRB) assay, and these compounds displayed cytotoxic activities against all the tested cell lines, with concentration causing 50% cell growth inhibition (GI50) values ranging from 4.9 to 10.8 µM, while a positive control, adriamycin, showed GI50 values of 0.13–0.17 µM. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Agents from Marine Sources)
►▼ Show Figures

Figure 1

13 pages, 2607 KiB  
Article
A Survey of Didemnin Depsipeptide Production in Tistrella
by Robert J. Stankey, Don Johnson, Brendan M. Duggan, David A. Mead and James J. La Clair
Mar. Drugs 2023, 21(2), 56; https://doi.org/10.3390/md21020056 - 17 Jan 2023
Cited by 2 | Viewed by 2124
Abstract
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the recent re-evaluation of these compounds including synthetically derived [...] Read more.
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the recent re-evaluation of these compounds including synthetically derived dehydrodidemnin B or Aplidine, has led to their advancement towards antiviral applications. While conventionally associated with production in colonial tunicates of the family Didemnidae, recent studies have identified their biosynthetic gene clusters from the marine–derived bacteria Tistrella mobilis. While these studies confirm the production of didemnin X/Y, the low titer and general lack of understanding of their biosynthesis in Tistrella currently prevents the development of effective microbial or synthetic biological approaches for their production. To this end, we conducted a survey of known species of Tistrella and report on their ability to produce the didemnin depsipeptides. These data were used to develop conditions to produce didemnin B at titers over 15 mg/L. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Agents from Marine Sources)
►▼ Show Figures

Graphical abstract

14 pages, 2214 KiB  
Article
Antibacterial Mechanism of Chitosan–Gentamicin and Its Effect on the Intestinal Flora of Litopenaeus vannamei Infected with Vibrio parahaemolyticus
by Lefan Li, Fengyan Liang, Chengpeng Li, Tingting Hou and Dong-an Xu
Mar. Drugs 2022, 20(11), 702; https://doi.org/10.3390/md20110702 - 09 Nov 2022
Cited by 2 | Viewed by 1625
Abstract
To explore the application of chitosan–gentamicin conjugate (CS-GT) in inhibiting Vibrio parahaemolyticus (V. parahaemolyticus), which is an important pathogen in aquatic animals worldwide, the antimicrobial activity of CS-GT and the effects of a CS-GT dose on the intestine histopathology and intestinal [...] Read more.
To explore the application of chitosan–gentamicin conjugate (CS-GT) in inhibiting Vibrio parahaemolyticus (V. parahaemolyticus), which is an important pathogen in aquatic animals worldwide, the antimicrobial activity of CS-GT and the effects of a CS-GT dose on the intestine histopathology and intestinal flora of V. parahaemolyticus-infected shrimps were explored. The results showed that CS-GT possessed broad-spectrum antibacterial activity, with minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and half inhibitory concentration (IC50) of 20.00 ± 0.01, 75.00 ± 0.02 and 18.72 ± 3.17 μg/mL for V. parahaemolyticus, respectively. Further scanning electron microscope and cell membrane damage analyses displayed that the electrostatic interaction of CS-GT with cell membrane strengthened after CS grafted GT, resulting in leakage of nucleic acid and electrolytes of V. parahaemolyticus. On the other hand, histopathology investigation indicated that high (100 mg/kg) and medium (50 mg/kg) doses of CS-GT could alleviate the injury of a shrimp’s intestine caused by V. parahaemolyticus. Further 16S rRNA gene sequencing analysis found high and medium dose of CS-GT could effectively inhabit V. parahaemolyticus invasion and reduce intestinal dysfunction. In conclusion, CS-GT possesses good antibacterial activity and could protect shrimps from pathogenic bacteria infection. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Agents from Marine Sources)
►▼ Show Figures

Figure 1

13 pages, 1229 KiB  
Article
Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001
by Diaa T. A. Youssef, Lamiaa A. Shaala and Grégory Genta-Jouve
Mar. Drugs 2022, 20(7), 451; https://doi.org/10.3390/md20070451 - 10 Jul 2022
Cited by 5 | Viewed by 2182
Abstract
Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+)-citreoisocoumarin (3) [...] Read more.
Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+)-citreoisocoumarin (3) and (−)-6,8-di-O-methylcitreoisocoumarin (4). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. Asperopiperazine A (1) is a cyclic dipeptide of leucine and phenylalanine moieties, which are substituted with an N-methyl and an N-acetyl group, respectively. On the other hand, asperopiperazine B (2) is a cyclic dipeptide of proline and phenylalanine moieties with a hydroxyl group at C-2 of the proline part. The absolute configuration of the amino acid moieties in 1 and 2 were determined by Marfey’s analyses and DFT NMR chemical shift calculations, leading to their assignment as cyclo(l-NMe-Leu-l-NAc-Phe) and cyclo(d-6-OH-Pro-l-Phe), respectively. Asperopiperazines A and B displayed higher antimicrobial effects against Escherichia coli and Staphylococcus aureus than Candida albicans. Furthermore, compounds 1–4 displayed variable growth inhibitory effects towards HCT 116 and MDA-MB-231 cells, with asperopiperazine A as the most active one towards HCT 116. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Agents from Marine Sources)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 1206 KiB  
Review
Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions
by Biswajita Pradhan, Rabindra Nayak, Prajna Paramita Bhuyan, Srimanta Patra, Chhandashree Behera, Sthitaprajna Sahoo, Jang-Seu Ki, Alessandra Quarta, Andrea Ragusa and Mrutyunjay Jena
Mar. Drugs 2022, 20(6), 403; https://doi.org/10.3390/md20060403 - 18 Jun 2022
Cited by 19 | Viewed by 3421
Abstract
The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It has previously been shown that several bioactive compounds derived [...] Read more.
The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It has previously been shown that several bioactive compounds derived from marine algae exhibit antibacterial activity. Similarly, polyphenolic compounds are generally known to possess promising antibacterial capacity, among other capacities. Phlorotannins (PTs), an important group of algae-derived polyphenolic compounds, have been considered potent antibacterial agents both as single drug entities and in combination with commercially available antibacterial drugs. In this context, this article reviews the antibacterial properties of polyphenols in brown algae, with particular reference to PTs. Cell death through various molecular modes of action and the specific inhibition of biofilm formation by PTs were the key discussion of this review. The synergy between drugs was also discussed in light of the potential use of PTs as adjuvants in the pharmacological antibacterial treatment. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Agents from Marine Sources)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop