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Marine Drugs, Volume 19, Issue 2

February 2021 - 75 articles

Cover Story: Biodiscovery from understudied taxa, such as the rare actinomycetes combined with underexplored environments, such as polar marine ecosystems, holds promise for uncovering novel biosynthetic and chemical diversity. However, with increasingly complex specialised metabolite datasets, methods to prioritize this potential are greatly needed. In this study, NPLinker, a new and publicly available software framework was used to integrate, link, and rank (based on scoring functions) metabolomics (molecular families) and genomics (gene cluster families) datasets. This automated approach enables accelerated and informed comparative metabologenomics and, combined with bioactivity data, demonstrates an exciting step towards an integrated-data era for microbial discovery. View this paper.
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Articles (75)

  • Article
  • Open Access
8 Citations
3,215 Views
10 Pages

New from Old: Thorectandrin Alkaloids in a Southern Australian Marine Sponge, Thorectandra choanoides (CMB-01889)

  • Shamsunnahar Khushi,
  • Angela A. Salim,
  • Ahmed H. Elbanna,
  • Laizuman Nahar and
  • Robert J. Capon

9 February 2021

Thorectandra choanoides (CMB-01889) was prioritized as a source of promising new chemistry from a library of 960 southern Australian marine sponge extracts, using a global natural products social (GNPS) molecular networking approach. The sponge was c...

  • Article
  • Open Access
13 Citations
3,687 Views
20 Pages

Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico

  • Ignacio Leyva-Valencia,
  • Jesús Ernestina Hernández-Castro,
  • Christine J. Band-Schmidt,
  • Andrew D. Turner,
  • Alison O’Neill,
  • Erick J. Núñez-Vázquez,
  • David J. López-Cortés,
  • José J. Bustillos-Guzmán and
  • Francisco E. Hernández-Sandoval

9 February 2021

Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events. Dinoflagellates that produ...

  • Article
  • Open Access
27 Citations
4,184 Views
12 Pages

New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

  • Peihai Li,
  • Mengqi Zhang,
  • Haonan Li,
  • Rongchun Wang,
  • Hairong Hou,
  • Xiaobin Li,
  • Kechun Liu and
  • Hao Chen

9 February 2021

Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), on...

  • Article
  • Open Access
20 Citations
4,567 Views
10 Pages

Lipid Inhibitory Effect of (−)-loliolide Isolated from Sargassum horneri in 3T3-L1 Adipocytes: Inhibitory Mechanism of Adipose-Specific Proteins

  • Hyo-Geun Lee,
  • Hyun-Soo Kim,
  • Jun-Geon Je,
  • Jin Hwang,
  • K. K. Asanka Sanjeewa,
  • Dae-Sung Lee,
  • Kyung-Mo Song,
  • Yun-Sang Choi,
  • Min-Cheol Kang and
  • You-Jin Jeon

8 February 2021

Sargassum horneri (S. horneri) is a well-known brown seaweed widely distributed worldwide. Several biological activities of S. horneri have been reported. However, its effects on lipid metabolism and the underlying mechanisms remain elusive. In the p...

  • Article
  • Open Access
10 Citations
3,504 Views
9 Pages

Tedaniophorbasins A and B—Novel Fluorescent Pteridine Alkaloids Incorporating a Thiomorpholine from the Sponge Tedaniophorbas ceratosis

  • Asadhawut Hiranrat,
  • Darren C. Holland,
  • Wilawan Mahabusarakam,
  • John N. A. Hooper,
  • Vicky M. Avery and
  • Anthony R. Carroll

7 February 2021

Two new fluorescent pteridine alkaloids, tedaniophorbasins A (1) and B (2), together with the known alkaloid N-methyltryptamine, were isolated, through application of mass directed purification, from the sponge Tedaniophorbas ceratosis collected from...

  • Review
  • Open Access
52 Citations
8,456 Views
23 Pages

Antiviral Potential of Algal Metabolites—A Comprehensive Review

  • António Pagarete,
  • Ana Sofia Ramos,
  • Pål Puntervoll,
  • Michael J. Allen and
  • Vítor Verdelho

6 February 2021

Historically, algae have stimulated significant economic interest particularly as a source of fertilizers, feeds, foods and pharmaceutical precursors. However, there is increasing interest in exploiting algal diversity for their antiviral potential....

  • Article
  • Open Access
36 Citations
3,849 Views
14 Pages

5 February 2021

Fucoxanthin (FX), a natural carotenoid found in seaweed with multiple functional activities, is unstable with a poor water solubility that limits its utilization. This study aimed to improve FX’s stability and bioavailability via the nano-encapsulati...

  • Article
  • Open Access
15 Citations
3,550 Views
11 Pages

5 February 2021

Synovial sarcoma is a rare but aggressive soft-tissue sarcoma associated with translocation t(X;18). Metastasis occurs in approximately 50% of all patients, and curative outcomes are difficult to achieve in this group. Since the efficacies of current...

  • Review
  • Open Access
27 Citations
5,642 Views
38 Pages

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

  • Anton N. Yurchenko,
  • Elena V. Girich and
  • Ekaterina A. Yurchenko

4 February 2021

Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microb...

  • Review
  • Open Access
65 Citations
8,073 Views
11 Pages

4 February 2021

Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts show significant neuroprotective and reparative activities. Seaweed polysaccharides might p...

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Mar. Drugs - ISSN 1660-3397