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Marine Drugs, Volume 18, Issue 11

November 2020 - 61 articles

Cover Story: The extract of a Pseudosuberites sp. sponge provided three new aryl alkaloids named suberitamides A–C. Assignment of the relative configuration of the four contiguous stereogenic centers in the conformationally flexible oxolane ring in suberitamide A was accomplished using a variety of contemporary NMR techniques. These included J-based methodologies that employed new NMR experiments for the accurate determination of heteronuclear coupling constants between protons and nonprotonated carbons. The ubiquitin ligase Cbl-b is an attractive potential target for immune system modulation, and suberitamides A and B inhibited autoubiquitination of Cbl-b at low micromolar concentrations. View this paper
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Articles (61)

  • Article
  • Open Access
22 Citations
4,103 Views
14 Pages

Exploiting Mannuronan C-5 Epimerases in Commercial Alginate Production

  • Anne Tøndervik,
  • Olav A. Aarstad,
  • Randi Aune,
  • Susan Maleki,
  • Philip D. Rye,
  • Arne Dessen,
  • Gudmund Skjåk-Bræk and
  • Håvard Sletta

18 November 2020

Alginates are one of the major polysaccharide constituents of marine brown algae in commercial manufacturing. However, the content and composition of alginates differ according to the distinct parts of these macroalgae and have a direct impact on the...

  • Article
  • Open Access
16 Citations
3,529 Views
12 Pages

New Monoterpenoids and Polyketides from the Deep-Sea Sediment-Derived Fungus Aspergillus sydowii MCCC 3A00324

  • Siwen Niu,
  • Longhe Yang,
  • Tingting Chen,
  • Bihong Hong,
  • Shengxiang Pei,
  • Zongze Shao and
  • Gaiyun Zhang

17 November 2020

Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1–11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed...

  • Article
  • Open Access
38 Citations
4,827 Views
17 Pages

Functional Characterization of a New GH107 Endo-α-(1,4)-Fucoidanase from the Marine Bacterium Formosa haliotis

  • Marlene Vuillemin,
  • Artem S. Silchenko,
  • Hang Thi Thuy Cao,
  • Maxim S. Kokoulin,
  • Vo Thi Dieu Trang,
  • Jesper Holck,
  • Svetlana P. Ermakova,
  • Anne S. Meyer and
  • Maria Dalgaard Mikkelsen

17 November 2020

Fucoidans from brown macroalgae are sulfated fucose-rich polysaccharides, that have several beneficial biological activities, including anti-inflammatory and anti-tumor effects. Controlled enzymatic depolymerization of the fucoidan backbone can help...

  • Review
  • Open Access
34 Citations
6,968 Views
29 Pages

Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply

  • Diana Pacheco,
  • Glacio Souza Araújo,
  • João Cotas,
  • Rui Gaspar,
  • João M. Neto and
  • Leonel Pereira

16 November 2020

The introduction of exotic organisms in marine ecosystems can lead to economic and ecological losses. Globally, seaweeds represent a significant part of these non-indigenous species (NIS), with 407 introduced algal species. Furthermore, the presence...

  • Article
  • Open Access
59 Citations
4,694 Views
15 Pages

Microwave-Assisted Extraction of Phlorotannins from Fucus vesiculosus

  • Sónia J. Amarante,
  • Marcelo D. Catarino,
  • Catarina Marçal,
  • Artur M. S. Silva,
  • Rita Ferreira and
  • Susana M. Cardoso

15 November 2020

Microwave-assisted extraction (MAE) was carried out to maximize the extraction of phlorotannins from Fucus vesiculosus using a hydroethanolic mixture as a solvent, as an alternative to the conventional method with a hydroacetonic mixture. Optimal MAE...

  • Article
  • Open Access
14 Citations
4,466 Views
18 Pages

Microbial Diversity and Phage–Host Interactions in the Georgian Coastal Area of the Black Sea Revealed by Whole Genome Metagenomic Sequencing

  • Ekaterine Jaiani,
  • Ia Kusradze,
  • Tamar Kokashvili,
  • Natia Geliashvili,
  • Nino Janelidze,
  • Adam Kotorashvili,
  • Nato Kotaria,
  • Archil Guchmanidze,
  • Marina Tediashvili and
  • David Prangishvili

14 November 2020

Viruses have the greatest abundance and highest genetic diversity in marine ecosystems. The interactions between viruses and their hosts is one of the hot spots of marine ecology. Besides their important role in various ecosystems, viruses, especiall...

  • Review
  • Open Access
81 Citations
11,462 Views
35 Pages

Pharmacokinetics of Marine-Derived Drugs

  • Alexander N. Shikov,
  • Elena V. Flisyuk,
  • Ekaterina D. Obluchinskaya and
  • Olga N. Pozharitskaya

9 November 2020

Marine organisms represent an excellent source of innovative compounds that have the potential for the development of new drugs. The pharmacokinetics of marine drugs has attracted increasing interest in recent decades due to its effective and potenti...

  • Article
  • Open Access
11 Citations
4,822 Views
13 Pages

Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.

  • Waleed A Abdel-Naime,
  • Atsushi Kimishima,
  • Andi Setiawan,
  • John Refaat Fahim,
  • Mostafa A. Fouad,
  • Mohamed Salah Kamel and
  • Masayoshi Arai

7 November 2020

The tumor microenvironment is a nutrient-deficient region that alters the cancer cell phenotype to aggravate cancer pathology. The ability of cancer cells to tolerate nutrient starvation is referred to as austerity. Compounds that preferentially targ...

  • Article
  • Open Access
23 Citations
5,236 Views
22 Pages

Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish

  • Dinusha C. Rajapaksha,
  • Shan L. Edirisinghe,
  • Chamilani Nikapitiya,
  • SHS Dananjaya,
  • Hyo-Jung Kwun,
  • Cheol-Hee Kim,
  • Chulhong Oh,
  • Do-Hyung Kang and
  • Mahanama De Zoysa

7 November 2020

In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL a...

  • Article
  • Open Access
13 Citations
2,368 Views
21 Pages

Kurilosides A1, A2, C1, D, E and F—Triterpene Glycosides from the Far Eastern Sea Cucumber Thyonidium (= Duasmodactyla) kurilensis (Levin): Structures with Unusual Non-Holostane Aglycones and Cytotoxicities

  • Alexandra S. Silchenko,
  • Anatoly I. Kalinovsky,
  • Sergey A. Avilov,
  • Pelageya V. Andrijaschenko,
  • Roman S. Popov,
  • Pavel S. Dmitrenok,
  • Ekaterina A. Chingizova and
  • Vladimir I. Kalinin

6 November 2020

Six new monosulfated triterpene tetra-, penta- and hexaosides, namely, the kurilosides A1 (1), A2 (2), C1 (3), D (4), E (5) and F (6), as well as the known earlier kuriloside A (7), having unusual non-holostane aglycones without lactone, have been is...

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Mar. Drugs - ISSN 1660-3397