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Marine Drugs, Volume 17, Issue 1

January 2019 - 72 articles

Cover Story: Novel methods were tested to culture the collagen-rich sponge Chondrosia reniformis in the proximity of floating fish cages. Attachment methods, plate materials, and plate orientation were compared. After three consecutive experiments, a culture protocol was established resulting in 86% survival and 170% growth for C. reniformis. Survival and growth of cultured explants near the fish farm polluted with organic waste was almost twice that at the pristine control site. This successful step towards production of sponge collagen in integrated aquacultures also reveals C. reniformis as a potential candidate for bioremediation of waters polluted with organic waste. View this paper.
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Articles (72)

  • Review
  • Open Access
78 Citations
12,043 Views
31 Pages

7 January 2019

Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Over the last decades, a great interest has been focused on the anti-tumour role of sponges and algae that constitute the major source of these bioactive...

  • Review
  • Open Access
293 Citations
22,764 Views
30 Pages

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

  • Geert Van Weelden,
  • Marcin Bobiński,
  • Karolina Okła,
  • Willem Jan Van Weelden,
  • Andrea Romano and
  • Johanna M. A. Pijnenborg

7 January 2019

Fucoidan is a natural derived compound found in different species of brown algae and in some animals, that has gained attention for its anticancer properties. However, the exact mechanism of action is currently unknown. Therefore, this review will ad...

  • Feature Paper
  • Article
  • Open Access
68 Citations
6,130 Views
16 Pages

Purification and Characterization of a Novel Pentadecapeptide from Protein Hydrolysates of Cyclina sinensis and Its Immunomodulatory Effects on RAW264.7 Cells

  • Wei Li,
  • Shengwang Ye,
  • Zhuangwei Zhang,
  • Jiachao Tang,
  • Huoxi Jin,
  • Fangfang Huang,
  • Zuisu Yang,
  • Yunping Tang,
  • Yan Chen and
  • Guofang Ding
  • + 1 author

6 January 2019

In the present study, peptide fractions of Cyclina sinensis hydrolysates, with molecular weight (MW) < 3 kDa and highest relative proliferation rate of murine macrophage cell line RAW 264.7, were purified by a series of chromatographic purificatio...

  • Article
  • Open Access
88 Citations
7,190 Views
13 Pages

5 January 2019

Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tiss...

  • Review
  • Open Access
21 Citations
6,024 Views
16 Pages

The Incidence of Tetrodotoxin and Its Analogs in the Indian Ocean and the Red Sea

  • Isidro José Tamele,
  • Marisa Silva and
  • Vitor Vasconcelos

5 January 2019

Tetrodotoxin (TTX) is a potent marine neurotoxin with bacterial origin. To date, around 28 analogs of TTX are known, but only 12 were detected in marine organisms, namely TTX, 11-oxoTTX, 11-deoxyTTX, 11-norTTX-6(R)-ol, 11-norTTX-6(S)-ol, 4-epiTTX, 4,...

  • Article
  • Open Access
33 Citations
6,942 Views
15 Pages

Development of an Integrated Mariculture for the Collagen-Rich Sponge Chondrosia reniformis

  • Mert Gökalp,
  • Tim Wijgerde,
  • Antonio Sarà,
  • Jasper M. De Goeij and
  • Ronald Osinga

5 January 2019

In this study, novel methods were tested to culture the collagen-rich sponge Chondrosia reniformis Nardo, 1847 (Demospongiae, Chondrosiida, Chondrosiidae) in the proximity of floating fish cages. In a trial series, survival and growth of cultured exp...

  • Article
  • Open Access
39 Citations
6,398 Views
15 Pages

Electrodialysis Extraction of Pufferfish Skin (Takifugu flavidus): A Promising Source of Collagen

  • Junde Chen,
  • Min Li,
  • Ruizao Yi,
  • Kaikai Bai,
  • Guangyu Wang,
  • Ran Tan,
  • Shanshan Sun and
  • Nuohua Xu

4 January 2019

Collagen is widely used in drugs, biomaterials, foods, and cosmetics. By-products of the fishing industry are rich sources of collagen, which can be used as an alternative to collagen traditionally harvested from land mammals. However, commercial app...

  • Article
  • Open Access
8 Citations
4,370 Views
9 Pages

Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian Crinoid Capillaster multiradiatus

  • Kah Yean Lum,
  • Anthony R. Carroll,
  • Merrick G. Ekins,
  • Silven Read,
  • Zahra Haq,
  • Ian Tietjen,
  • James St John and
  • Rohan A. Davis

4 January 2019

Capillasterin A (1), a novel pyrano[2,3-f]chromene, together with seven known naphthopyrones including comaparvin (2), TMC-256C1 (3), 6-methoxycomaparvin-5- methyl ether (4), 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (5), 5,8-dihy...

  • Article
  • Open Access
41 Citations
6,762 Views
17 Pages

Astaxanthin Attenuates Environmental Tobacco Smoke-Induced Cognitive Deficits: A Critical Role of p38 MAPK

  • Xia Yang,
  • An-Lei Guo,
  • Yi-Peng Pang,
  • Xiao-Jing Cheng,
  • Ting Xu,
  • Xin-Rui Li,
  • Jiao Liu,
  • Yu-Yun Zhang and
  • Yi Liu

3 January 2019

Increasing evidence indicates that environmental tobacco smoke (ETS) impairs cognitive function and induces oxidative stress in the brain. Recently, astaxanthin (ATX), a marine bioactive compound, has been reported to ameliorate cognitive deficits. H...

  • Article
  • Open Access
74 Citations
5,683 Views
18 Pages

2 January 2019

In this report, protein of hairtail (Trichiurus japonicas) muscle was separately hydrolyzed using five kinds of proteases (alcalase, trypsin, neutrase, pepsin, and papain), and the papain- and alcalase-hydrolysates showed higher 2,2-diphenyl-1-picryl...

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Mar. Drugs - ISSN 1660-3397