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Mar. Drugs 2019, 17(1), 27; https://doi.org/10.3390/md17010027

Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering

1
Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran
2
Department of Textile Engineering, Science and Research Branch, Islamic Azad University, P.O. Box 14515/775, Tehran, Iran
3
National Cell Bank Department, Pasteur Institute of Iran, Tehran 13164, Iran
4
Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, P.O. Box 11365/8639, Tehran, Iran
5
Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Azadi Avenue, P.O. Box 11365/8639, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 8 November 2018 / Revised: 20 December 2018 / Accepted: 27 December 2018 / Published: 5 January 2019
(This article belongs to the Special Issue Marine Biomimetics)
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Abstract

Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer fibers containing chitosan, polycaprolactone, and keratin using the co-axial electrospinning technique. Electron microscopic studies show that continuous and uniform fibers with an average diameter of 209 ± 47 nm were successfully fabricated. The fibers have a core-shell structure with a shell thickness of about 90 nm, as confirmed by transmission electron microscopy. By employing Fourier-transform infrared spectroscopy, the characteristic peaks of Aloe vera were detected, which indicate successful incorporation of this natural herb into the polymeric fibers. Tensile testing and hydrophilicity measurements indicated an ultimate strength of 5.3 MPa (elongation of 0.63%) and water contact angle of 89°. In-vitro biological assay revealed increased cellular growth and adhesion with the presence of Aloe vera without any cytotoxic effects. The prepared core-shell fibrous mats containing medical herbs have a great potential for wound healing applications. View Full-Text
Keywords: co-axial electrospinning; core-shell fiber; polysaccharide; Aloe vera extract; wound healing co-axial electrospinning; core-shell fiber; polysaccharide; Aloe vera extract; wound healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zahedi, E.; Esmaeili, A.; Eslahi, N.; Shokrgozar, M.A.; Simchi, A. Fabrication and Characterization of Core-Shell Electrospun Fibrous Mats Containing Medicinal Herbs for Wound Healing and Skin Tissue Engineering. Mar. Drugs 2019, 17, 27.

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